Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

2016 ◽  
Vol 8 (330) ◽  
pp. 330ra37-330ra37 ◽  
Author(s):  
Özge Uluçkan ◽  
Maria Jimenez ◽  
Susanne Karbach ◽  
Anke Jeschke ◽  
Osvaldo Graña ◽  
...  
Keyword(s):  
Bone Loss ◽  
Wnt Signaling ◽  
Skin Inflammation ◽  
Chronic Skin

scholarly journals Sequestosome 1/p62 enhances chronic skin inflammation

2021 ◽  
Author(s):  
Supawadee Sukseree ◽  
Latifa Bakiri ◽  
Marta Palomo Irigoyen ◽  
Özge Uluçkan ◽  
Peter Petzelbauer ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Sequestosome 1 ◽  
Chronic Skin

MicroRNA-124 alleviates chronic skin inflammation in atopic eczema via suppressing innate immune responses in keratinocytes

2017 ◽  
Vol 319 ◽  
pp. 53-60 ◽  
Author(s):  
Zhibo Yang ◽  
Bijun Zeng ◽  
Chang Wang ◽  
Haizhen Wang ◽  
Pan Huang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Atopic Eczema ◽  
Skin Inflammation ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Microrna 124 ◽  
Chronic Skin

The VEGF-C/VEGFR3 signaling pathway contributes to resolving chronic skin inflammation by activating lymphatic vessel function

2014 ◽  
Vol 73 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Asami Hagura ◽  
Jun Asai ◽  
Kazuichi Maruyama ◽  
Hideya Takenaka ◽  
Shigeru Kinoshita ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Lymphatic Vessel ◽  
Skin Inflammation ◽  
Chronic Skin

scholarly journals Comparison of the Inhibitory Activities of 5,6-Dihydroergosterol Glycoside α- and β-Anomers on Skin Inflammation

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 371 ◽  
Author(s):  
Tae Kim ◽  
Young Cho ◽  
HoonGyu Park ◽  
Tae Lee ◽  
Hakwon Kim
Keyword(s):  
Protein Expression ◽  
Inflammatory Diseases ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
New Drugs ◽  
Inflammatory Biomarker ◽  
Cytokines And Chemokines ◽  
Inflammatory Stimuli ◽  
Mrna And Protein Expression ◽  
Chronic Skin

Chronic skin inflammatory diseases, such as atopic dermatitis, are associated with a dysfunctional skin barrier due to an increase in various inflammatory stimuli, for instance inflammatory cytokines and chemokines. In particular, CCL17 and CCL22 expression is increased in patients with chronic skin inflammation. In this study, we synthesized several α- and β-anomers of dihydroergosterol (DHE)-glycosides and assessed their effects on CCL17 and CCL22 expression. We confirmed that the β-anomers of DHE-glycosides were superior to α-anomers of DHE-glycosides in inhibiting CCL17 and CCL22 mRNA and protein expression. In addition, we determined that DHE-glycoside β-anomers showed strong inhibitory activity towards pro-inflammatory cytokine mRNA and protein expression, including that of TNF-α, IL-6, and IL-1β- in stimulated HaCaT cells. These results imply that DHE-glycoside α- and β-anomers should be separated during synthesis of drugs for chronic skin inflammation. Our results also suggest that β-anomers of DHE-glycosides may play an important role as new drugs for chronic skin inflammation because of their ability to inhibit the skin inflammatory biomarker proteins CCL17 and CCL22.

scholarly journals Bacterial skin colonization and infections in patients with atopic dermatitis

2012 ◽  
Vol 87 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Vanessa Petry ◽  
Giancarlo Resende Bessa ◽  
Claudia Schermann Poziomczyck ◽  
Caio Fernando de Oliveira ◽  
Magda Blessmann Weber ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Secondary Infection ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
Skin Surface ◽  
Number Of Children ◽  
Chronic Skin ◽  
Systemic Antibiotics

Atopic Dermatitis is a chronic inflammatory skin disease that affects a large number of children and adults. The disease results from an interaction between genetic predisposition, host environment, skin barrier defects, and immunological factors. A major aggravating factor associated with Atopic Dermatitis is the presence of microorganisms on the patient's skin surface. Staphylococcus aureus and Streptococcus pyogenes, for instance, can exacerbate chronic skin inflammation. As a result, antimicrobials have often been prescribed to control the acute phase of the disease. However, increased bacterial resistance to antimicrobial agents has made it difficult for dermatologists to prescribe appropriate medication. In the presence of disseminated dermatitis with secondary infection, systemic antibiotics need to be prescribed; however, treatment should be individualized, in an attempt to find the most effective antibiotic with fewer side effects. Also, the medication should be used for as short as possible in order to minimize bacterial resistance.

scholarly journals An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93665 ◽  
Author(s):  
Silvana Zgraggen ◽  
Reto Huggenberger ◽  
Katrin Kerl ◽  
Michael Detmar
Keyword(s):  
Skin Inflammation ◽  
Chronic Skin ◽  
Cxcr4 Axis

MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes

2014 ◽  
Vol 134 (4) ◽  
pp. 836-847.e11 ◽  
Author(s):  
Ana Rebane ◽  
Toomas Runnel ◽  
Alar Aab ◽  
Julia Maslovskaja ◽  
Beate Rückert ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Immune Responses ◽  
Skin Inflammation ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Chronic Skin

scholarly journals An Important Role of Blood and Lymphatic Vessels in Inflammation and Allergy

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Silvana Zgraggen ◽  
Alexandra M. Ochsenbein ◽  
Michael Detmar
Keyword(s):  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Lymphatic Vessels ◽  
Allergic Inflammation ◽  
Skin Inflammation ◽  
Chronic Inflammatory Diseases ◽  
Chronic Skin ◽  
Targeted Inhibition ◽  
Endothelial Growth Factor

Angiogenesis and lymphangiogenesis, the growth of new vessels from preexisting ones, have received increasing interest due to their role in tumor growth and metastatic spread. However, vascular remodeling, associated with vascular hyperpermeability, is also a key feature of many chronic inflammatory diseases including asthma, atopic dermatitis, psoriasis, and rheumatoid arthritis. The major drivers of angiogenesis and lymphangiogenesis are vascular endothelial growth factor- (VEGF-)A and VEGF-C, activating specific VEGF receptors on the lymphatic and blood vascular endothelium. Recent experimental studies found potent anti-inflammatory responses after targeted inhibition of activated blood vessels in models of chronic inflammatory diseases. Importantly, our recent results indicate that specific activation of lymphatic vessels reduces both acute and chronic skin inflammation. Thus, antiangiogenic and prolymphangiogenic therapies might represent a new approach to treat chronic inflammatory disorders, including those due to chronic allergic inflammation.

scholarly journals Analisis Penyebab dan Edukasi Dokter Pada Penyakit Neurodermatitis Sirkumskripta

2019 ◽  
Author(s):  
Victoria Tasya Arifa Guardiola
Keyword(s):  
General Practitioners ◽  
Skin Inflammation ◽  
Skin Surface ◽  
Early Management ◽  
Chronic Skin

nurodermatitis is a chronic skin inflammation, itchy cryptography, and is characterized by lichenification. Likenification arises secondary and histologically has the characteristics of acanthosis and hyperkeratosis, and clinically appears to be thickening of the skin, with an increase in skin surface lines in the area. Neurodermatitis therapy aims to break the cycle of itching, because basically the action of scratching an itchy lesion will actually aggravate the disease. Topical corticostreoid treatment is the treatment of choice. Administration of oral antihistamines is used to reduce complaints of pruritus.Based on the Indonesian Doctors Competency Standards (SKDI), general practitioners must be able to diagnose and provide early management of neurodermatitis patients then refer to skin and sex specialists

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