scholarly journals An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93665 ◽  
Author(s):  
Silvana Zgraggen ◽  
Reto Huggenberger ◽  
Katrin Kerl ◽  
Michael Detmar
Keyword(s):  
Skin Inflammation ◽  
Chronic Skin ◽  
Cxcr4 Axis

scholarly journals Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis—A New Look on an Old Story: A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1179
Author(s):  
Andrzej Kazimierz Jaworek ◽  
Jacek Cezary Szepietowski ◽  
Przemysław Hałubiec ◽  
Anna Wojas-Pelc ◽  
Jolanta Jaworek
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Skin Inflammation ◽  
Inflammatory Dermatosis ◽  
Sleep Abnormalities ◽  
Chronic Skin ◽  
Endogenous Substances

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possesses strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with a focus on the antioxidant and immunomodulatory effects of MT.

The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice

2010 ◽  
Vol 20 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Trine Bertelsen ◽  
Lars Iversen ◽  
Jette Lindorff Riis ◽  
J. Simon C. Arthur ◽  
Bo Martin Bibby ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Skin Inflammation ◽  
Chronic Skin

scholarly journals Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

2010 ◽  
Vol 207 (10) ◽  
pp. 2255-2269 ◽  
Author(s):  
Reto Huggenberger ◽  
Stefan Ullmann ◽  
Steven T. Proulx ◽  
Bronislaw Pytowski ◽  
Kari Alitalo ◽  
...  
Keyword(s):  
Antiangiogenic Therapy ◽  
Lymphatic Vessels ◽  
Skin Inflammation ◽  
Vegf Receptor ◽  
Epidermal Hyperplasia ◽  
Edema Formation ◽  
Inflammatory Infiltration ◽  
Chronic Skin ◽  
Stimulation Of

The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function-blocking antibodies in the established keratin 14 (K14)–VEGF-A transgenic (Tg) mouse model of chronic cutaneous inflammation. Although treatment with an anti–VEGFR-2 antibody inhibited skin inflammation, epidermal hyperplasia, inflammatory infiltration, and angiogenesis, systemic inhibition of VEGFR-3, surprisingly, increased inflammatory edema formation and inflammatory cell accumulation despite inhibition of lymphangiogenesis. Importantly, chronic Tg delivery of the lymphangiogenic factor VEGF-C to the skin of K14-VEGF-A mice completely inhibited development of chronic skin inflammation, epidermal hyperplasia and abnormal differentiation, and accumulation of CD8 T cells. Similar results were found after Tg delivery of mouse VEGF-D that only activates VEGFR-3 but not VEGFR-2. Moreover, intracutaneous injection of recombinant VEGF-C156S, which only activates VEGFR-3, significantly reduced inflammation. Although lymphatic drainage was inhibited in chronic skin inflammation, it was enhanced by Tg VEGF-C delivery. Together, these results reveal an unanticipated active role of lymphatic vessels in controlling chronic inflammation. Stimulation of functional lymphangiogenesis via VEGFR-3, in addition to antiangiogenic therapy, might therefore serve as a novel strategy to treat chronic inflammatory disorders of the skin and possibly also other organs.

scholarly journals Melatonin as an Antioxidant and Immunomodulator in Atopic Dermatitis–A New Look on an Old Story–A Review

2021 ◽  
Author(s):  
Andrzej Kazimierz Jaworek ◽  
Jacek C Szepietowski ◽  
Przemysław Hałubiec ◽  
Anna Wojas-Pelc ◽  
Jolanta Jaworek
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Skin Inflammation ◽  
Inflammatory Dermatosis ◽  
Sleep Abnormalities ◽  
Chronic Skin ◽  
Endogenous Substances

Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and recurrent course, which significantly reduces the quality of life. Sleep disturbances are considered to be remarkably burdensome ailments in the patients with AD, and are routinely included during assessment of disease severity. Therefore, endogenous substances engaged in the control of circadian rhythms might be important in pathogenesis of AD and, possibly, be used as biomarkers of disease severity or even in development of novel therapies. Melatonin (MT), the indoleamine produced by pineal gland (but also by multiple other tissues, including skin), plays a pivotal role in maintaining the sleep/wake homeostasis. Additionally, it possess strong antioxidant and anti-inflammatory properties, which might directly link chronic skin inflammation and sleep abnormalities characteristic of AD. The objective of this work is to systematically present and summarize the results of studies (both experimental and clinical) that investigated the role of MT in the AD, with focus on the antioxidant and immunomodulatory effects of MT.

scholarly journals Sequestosome 1/p62 enhances chronic skin inflammation

2021 ◽  
Author(s):  
Supawadee Sukseree ◽  
Latifa Bakiri ◽  
Marta Palomo Irigoyen ◽  
Özge Uluçkan ◽  
Peter Petzelbauer ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Sequestosome 1 ◽  
Chronic Skin

scholarly journals P01.17 * ROLE OF PHOSPHATYDILCHOLINE-SPECIFIC PHOSPHOLIPASE C IN MODULATION OF CXCL12/CXCR4 AXIS IN A HUMAN GLIOMA CELL LINE

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii30-ii30 ◽  
Author(s):  
L. Mercurio ◽  
A. Ricci ◽  
S. Cecchetti ◽  
A. Pacella ◽  
F. Podo ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Cell Line ◽  
Glioma Cell ◽  
Glioma Cell Line ◽  
Human Glioma ◽  
Human Glioma Cell Line ◽  
Human Glioma Cell ◽  
Cxcr4 Axis

scholarly journals ROLE OF SDF-1α/CXCR4 AXIS TO THE CARDIOPROTECTIVE EFFECT OF ISCHEMIC POST-CONDITIONING IN ISOLATED RAT HEART

2013 ◽  
Vol 61 (10) ◽  
pp. E217
Author(s):  
Jeong-Su Kim ◽  
Ju-Hyun Park ◽  
Kook-Jin Chun ◽  
Young-Ho Jang ◽  
June-Hong Kim ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cardioprotective Effect ◽  
Cxcr4 Axis ◽  
Isolated Rat

Understanding the Experiences of Anger in the Onset and Progression of Psoriasis: A Qualitative Study Using Social Media (Preprint)

2021 ◽  
Author(s):  
Olivia Hughes ◽  
Rachael Hunter
Keyword(s):  
Social Media ◽  
Qualitative Interviews ◽  
Psychosocial Interventions ◽  
Skin Condition ◽  
Future Research ◽  
Social Media Platforms ◽  
Chronic Skin ◽  
Skin Conditions ◽  
The Impact

BACKGROUND Psoriasis is a chronic inflammatory skin condition, which can be affected by stress. Living with psoriasis can trigger negative emotions, which may influence quality of life. OBJECTIVE This study explored the experiences of people with psoriasis with attention to the potential role of anger in the onset and progression of the chronic skin condition. METHODS Semi-structured qualitative interviews were conducted with twelve participants (n=5 females, n=7 males) recruited online from an advert on a patient charity’s social media platforms. Data were transcribed and analysed using thematic analysis. RESULTS Four key themes were identified: (1) ‘I get really angry with the whole situation:’ anger at the self and others, (2) the impact of anger on psoriasis: angry skin, (3) shared experiences of distress, and (4) moving past anger to affirmation. CONCLUSIONS Findings suggest that anger can have a perceived impact on psoriasis through contributing to sensory symptoms and unhelpful coping cycles and point to a need for enhanced treatment with more psychological support. The findings also highlight the continued stigma which exists for people living with skin conditions and how this may contribute to, and sustain, anger for those individuals. Future research could usefully focus on developing targeted psychosocial interventions to promote healthy emotional coping with psoriasis.

scholarly journals Correlation between Serum Homocysteine and Vitiligo Area Scoring Index

2017 ◽  
Vol 5 (3) ◽  
pp. 332-334 ◽  
Author(s):  
Dina R. U. Hasibuan ◽  
Imam B. Putra ◽  
Nelva K. Jusuf
Keyword(s):  
Family History ◽  
Homocysteine Level ◽  
Cross Sectional ◽  
Characteristic Finding ◽  
Serum Homocysteine ◽  
Gender And Age ◽  
Significant Difference ◽  
Chronic Skin ◽  
Scoring Index

Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. Aim : To determine correlation between serum homocysteine and vitiligo area scoring index (VASI)Subject and method: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood’s lamp examinations then VASI score was determined and same numbers of control. We conducted blood sampling and measurement of serum homocysteine level to the patients.Results: There is no significant correlation between serum homocysteine and VASI score (p= 0,133, r= 0,281), family history (p=0,447), and duration of vitiligo (p= 0,993, r= 0,002). There is no significant difference between serum homocysteine in vitiligo patients and controls (p= 0,191). There is a correlation between serum homocysteine with gender (p= 0,001) and age (p= 0,036;r= 0,385)  in vitiligo patient but not in controls (p= 0,266), (p= 0,872; r= 0,031). There is a correlation between serum homocysteine and types of vitiligo. Conclusion: There is no significant correlation between serum homocysteine and VASI score, family history, and duration of vitiligo. There is no significant difference between serum homocysteine in vitiligo patients and controls. There is a correlation between serum homocysteine with gender and age in vitiligo patients.

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