Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides
2009 ◽
Vol 53
(8)
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pp. 3565-3568
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Keyword(s):
ABSTRACT Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
1995 ◽
Vol 121
(S1)
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pp. S37-S37
1998 ◽
Vol 72
(3)
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pp. 1886-1893
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2006 ◽
Vol 87
(2)
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pp. 411-418
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1996 ◽
Vol 40
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pp. 1491-1497
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2000 ◽
Vol 11
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pp. 135-140
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2001 ◽
Vol 75
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pp. 7973-7986
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1993 ◽
Vol 167
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pp. 789-797
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2000 ◽
Vol 44
(8)
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pp. 2093-2099
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