Clonal Complex 258, the Most Frequently Found Multilocus Sequence Type Complex in KPC-2-Producing Klebsiella pneumoniae Isolated in Brazilian Hospitals

We report here the draft genome sequence of a Klebsiella pneumoniae strain 1194/11, belonging to the hospital-associated sequence type 340 (ST340; clonal complex CC258), isolated from a catheter tip culture from a pediatric patient. The multidrug-resistant strain coproduced the 16S rRNA methyltransferase rRNA RmtG and β-lactamases KPC-2 and CTX-M-15.

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Draft genome sequence of a CTX-M-15-producing Klebsiella pneumoniae sequence type 340 (clonal complex 258) isolate from a food-producing animal

Journal of Global Antimicrobial Resistance ◽

10.1016/j.jgar.2016.07.012 ◽

2016 ◽

Vol 7 ◽

pp. 67-68 ◽

Cited By ~ 6

Author(s):

Louise Cerdeira ◽

Ketrin C. Silva ◽

Miriam R. Fernandes ◽

Susan Ienne ◽

Tiago A. de Souza ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Genome Sequence ◽

Clonal Complex ◽

Draft Genome ◽

Sequence Type ◽

Draft Genome Sequence

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Dissemination ofblaKPC-2by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae Species in Brazil

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01783-10 ◽

2011 ◽

Vol 55 (7) ◽

pp. 3579-3583 ◽

Cited By ~ 114

Author(s):

Leonardo Neves Andrade ◽

Tânia Curiao ◽

Joseane Cristina Ferreira ◽

Juliana Mucedola Longo ◽

Eduardo Carneiro Clímaco ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Serratia Marcescens ◽

Rio De Janeiro ◽

Clonal Complex ◽

Enterobacter Cloacae ◽

Sao Paulo ◽

Sequence Type ◽

Citrobacter Freundii ◽

Content Type ◽

Hospital Outbreak

ABSTRACTThis article reports the spread ofblaKPC-2in the Sao Paulo and Rio de Janeiro states, facilitated by globally spreadK. pneumoniaeclonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of theEnterobacteriaceae(Enterobacter cloacae,Serratia marcescens, andCitrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.

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Faculty Opinions recommendation of Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718490115.793497306 ◽

2014 ◽

Author(s):

Virginia L Miller

Keyword(s):

Genetic Structure ◽

Klebsiella Pneumoniae ◽

Sequence Type ◽

Beta Lactamase ◽

Esterase Gene ◽

Lactamase Gene

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Faculty Opinions recommendation of A 4.5-Year Within-Patient Evolution of a Colistin-Resistant Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Sequence Type 258.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733092378.793545532 ◽

2018 ◽

Author(s):

Rasmus Leistner

Keyword(s):

Klebsiella Pneumoniae ◽

Sequence Type ◽

Klebsiella Pneumoniae Carbapenemase

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A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1361 ◽

2020 ◽

pp. 1-4

Author(s):

Ester Solter ◽

Jason C. Kwong ◽

Aaron Walton ◽

Norelle Sherry ◽

Benjamin P. Howden ◽

...

Keyword(s):

Escherichia Coli ◽

Klebsiella Pneumoniae ◽

Common Ancestor ◽

Sequence Type ◽

Second Phase ◽

New Delhi ◽

Genetic Sequencing ◽

Klebsiella Pneumoniae Carbapenemase ◽

Carbapenemase Gene

Abstract We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.

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Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1521 ◽

2020 ◽

Vol 71 (Supplement_4) ◽

pp. S436-S439

Author(s):

Qingyu Shi ◽

Dandan Yin ◽

Renru Han ◽

Yan Guo ◽

Yonggui Zheng ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Infection Control ◽

Polymyxin B ◽

Sequence Type ◽

First Report ◽

Clinical Strains

Abstract This is the first report of ceftazidime–avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem–vaborbactam, cefepime–zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00404-17 ◽

2017 ◽

Vol 61 (8) ◽

Cited By ~ 2

Author(s):

Astrid V. Cienfuegos-Gallet ◽

Liang Chen ◽

Barry N. Kreiswirth ◽

J. Natalia Jiménez

Keyword(s):

Klebsiella Pneumoniae ◽

Plasmid Dna ◽

Clonal Expansion ◽

Genetic Alterations ◽

Sequence Type ◽

Chromosomal Integration ◽

Colistin Resistance ◽

Content Type ◽

Carbapenem Resistant ◽

Single Locus Variant

ABSTRACT Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.

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