scholarly journals Foreign Travel Is a Major Risk Factor for Colonization with Escherichia coli Producing CTX-M-Type Extended-Spectrum β-Lactamases: a Prospective Study with Swedish Volunteers

2010 ◽  
Vol 54 (9) ◽  
pp. 3564-3568 ◽  
Author(s):  
Thomas Tängdén ◽  
Otto Cars ◽  
Åsa Melhus ◽  
Elisabeth Löwdin
Keyword(s):  
Escherichia Coli ◽  
Risk Factor ◽  
Prospective Study ◽  
International Travel ◽  
Major Risk Factor ◽  
Additional Risk Factor ◽  
Extended Spectrum Beta Lactamase ◽  
Foreign Travel ◽  
Extended Spectrum ◽  
A Prospective Study

ABSTRACT Foreign travel has been suggested to be a risk factor for the acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. To our knowledge, this has not previously been demonstrated in a prospective study. Healthy volunteers traveling outside Northern Europe were enrolled. Rectal swabs and data on potential travel-associated risk factors were collected before and after traveling. A total of 105 volunteers were enrolled. Four of them did not complete the study, and one participant carried ESBL-producing Escherichia coli before travel. Twenty-four of 100 participants with negative pretravel samples were colonized with ESBL-producing Escherichia coli after the trip. All strains produced CTX-M enzymes, mostly CTX-M-15, and some coproduced TEM or SHV enzymes. Coresistance to several antibiotic subclasses was common. Travel to India was associated with the highest risk for the acquisition of ESBLs (88%; n = 7). Gastroenteritis during the trip was an additional risk factor (P = 0.003). Five of 21 volunteers who completed the follow-up after 6 months had persistent colonization with ESBLs. This is the first prospective study demonstrating that international travel is a major risk factor for colonization with ESBL-producing Enterobacteriaceae. Considering the high acquisition rate of 24%, it is obvious that global efforts are needed to meet the emergence and spread of CTX-M enzymes and other antimicrobial resistances.

Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study

1995 ◽  
Vol 108 (3) ◽  
pp. 812-817 ◽  
Author(s):  
Mauro Borzio ◽  
Savino Bruno ◽  
Massimo Roncalli ◽  
Guido Colloredo Mels ◽  
Giorgio Ramella ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Prospective Study ◽  
Liver Cell ◽  
Major Risk Factor ◽  
Liver Cell Dysplasia ◽  
A Prospective Study

Hepatitis C: An Additional Risk Factor for Poor Bowel Preparation — A Prospective Study

2015 ◽  
Vol 110 ◽  
pp. S591
Author(s):  
Siddharth Verma ◽  
Bharat Puchakayala ◽  
Newaz Hossain ◽  
Muhammad Niaz ◽  
Zhanna Ivanov ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hepatitis C ◽  
Prospective Study ◽  
Bowel Preparation ◽  
Additional Risk Factor ◽  
Additional Risk ◽  
A Prospective Study

scholarly journals Extended-Spectrum Beta-Lactamase Producing Bacteria: Epidemiology, Risk Factors, Diagnostic Methodology, and Antimicrobial Susceptibility Profile: A Prospective Study at a University Hospital in Western Saudi Arabia

2019 ◽  
Vol 9 (2) ◽  
pp. 5-18
Author(s):  
Dalal Mohammad Alashari ◽  
Maha Mahmoud Al-Alawi ◽  
Asif Ahmad Jiman-Fatani
Keyword(s):  
Risk Factors ◽  
Multidrug Resistance ◽  
Prospective Study ◽  
Antimicrobial Susceptibility ◽  
University Hospital ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Vitek 2 ◽  
A Prospective Study

Objective: To study the prevalence and incidence of extended-spectrum beta-lactamase -producing microorganisms, microbiological characteristics and antimicrobial-susceptibility patterns. Methods: A prospective study involving all cases of extended-spectrum beta-lactamase -producing microorganisms among all bacteriological samples collected over a 1-year period from 11 November 2015 to 10 November 2016, in the Clinical and Molecular Microbiology Laboratory at King Abdulaziz University Hospital, Jeddah. Detection of extended-spectrum beta-lactamase-producing microorganisms and antimicrobial-susceptibility profiles were done using automated Vitek 2 system. Clinical data such as recent use of antibiotics or invasive devices were investigated as risk factors for multidrug resistance. Results: The prevalence of extended-spectrum beta-lactamase-producing microorganisms was 5.4% (95% CI = 4.7% – 6.2%); for an incidence = 54 per 1,000 isolates-years. Distribution by species showed 70.0% Escherichia coli, 28.5% Klebsiella pneumoniae and 1.5% Proteus mirabilis. Vitek 2 system showed 6% of false positive ESBL detections by reference to confirmatory E-test. Antimicrobial- susceptibility tests showed that 86.5% of beta-lactamase-producing strains were resistant to ≥ 1 other antimicrobial class and 20% were multidrug resistant. Univariate logistic regression showed that the presence of multidrug resistance was significantly predicted by age (OR = 1.02; P = 0.026), use of urinary catheter (OR = 2.05; P = 0.046) and number of devices used (OR = 1.60; P = 0.046); only age (OR = 1.02; P = 0.022) was significant in the multivariate model. Conclusion: Clinicians and microbiologists should maintain a high level of alertness and contribute for effective screening and adequate treatment of infections caused by beta-lactamase-producing organisms according to international guidelines and the local epidemiological picture.

scholarly journals Identification of a Cluster of Extended-spectrum Beta-Lactamase–Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans

2020 ◽  
Author(s):  
Lisandra Aguilar-Bultet ◽  
Claudia Bagutti ◽  
Adrian Egli ◽  
Monica Alt ◽  
Laura Maurer Pekerman ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Prospective Study ◽  
Sequence Type ◽  
Clinical Samples ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
And Migration ◽  
A Prospective Study

Abstract We report a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101, derived from 1 poultry and 2 clinical samples collected within the setting of a prospective study designed to determine the diversity and migration of ESBL-producing Enterobacterales between humans, foodstuffs, and wastewater.

Sign in / Sign up

Export Citation Format

Share Document