Immobility - a major risk factor for development of pressure ulcers among adult hospitalized patients: a prospective study

ABSTRACT Foreign travel has been suggested to be a risk factor for the acquisition of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. To our knowledge, this has not previously been demonstrated in a prospective study. Healthy volunteers traveling outside Northern Europe were enrolled. Rectal swabs and data on potential travel-associated risk factors were collected before and after traveling. A total of 105 volunteers were enrolled. Four of them did not complete the study, and one participant carried ESBL-producing Escherichia coli before travel. Twenty-four of 100 participants with negative pretravel samples were colonized with ESBL-producing Escherichia coli after the trip. All strains produced CTX-M enzymes, mostly CTX-M-15, and some coproduced TEM or SHV enzymes. Coresistance to several antibiotic subclasses was common. Travel to India was associated with the highest risk for the acquisition of ESBLs (88%; n = 7). Gastroenteritis during the trip was an additional risk factor (P = 0.003). Five of 21 volunteers who completed the follow-up after 6 months had persistent colonization with ESBLs. This is the first prospective study demonstrating that international travel is a major risk factor for colonization with ESBL-producing Enterobacteriaceae. Considering the high acquisition rate of 24%, it is obvious that global efforts are needed to meet the emergence and spread of CTX-M enzymes and other antimicrobial resistances.

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4622 The endoscopist is the major risk factor for complications of endoscopc sphincterotomy: final results of a prospective study.

Gastrointestinal Endoscopy ◽

10.1016/s0016-5107(00)14469-4 ◽

2000 ◽

Vol 51 (4) ◽

pp. AB185

Author(s):

Thomas Rabenstein ◽

S. Roggenbuck ◽

B. Famke ◽

P. Martus ◽

J. Hochberger ◽

...

Keyword(s):

Risk Factor ◽

Prospective Study ◽

Major Risk Factor ◽

A Prospective Study

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Anemia predicts poor outcomes of COVID-19 in hospitalized patients: a prospective study in Iran

BMC Infectious Diseases ◽

10.1186/s12879-021-05868-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Masood Faghih Dinevari ◽

Mohammad Hossein Somi ◽

Elham Sadeghi Majd ◽

Mahdieh Abbasalizad Farhangi ◽

Zeinab Nikniaz

Keyword(s):

Prospective Study ◽

High Sensitivity ◽

Hospitalized Patients ◽

Icu Admission ◽

Reactive Protein ◽

Hs Crp ◽

Prospective Association ◽

Poor Outcomes ◽

A Prospective Study ◽

Ventilator Requirement

Abstract Background There are limited number of studies with controversial findings regarding the association between anemia at admission and coronavirus disease 2019 (COVID-19) outcomes. Therefore, in this research, we aimed to investigate the prospective association between anemia and COVID-19 outcomes in hospitalized patients in Iran. Methods In this prospective study, the data of 1274 consecutive patients hospitalized due to COVID-19 were statistically analyzed. All biomarkers, including hemoglobin and high-sensitivity C-reactive protein (hs-CRP) levels were measured using standard methods. Anemia was defined as a hemoglobin (Hb) concentration of less than 13 g/dL and 12 g/dL in males and females, respectively. Assessing the association between anemia and COVID-19 survival in hospitalized patients was our primary endpoint. Results The mean age of the participants was 64.43 ± 17.16 years, out of whom 615 (48.27%) were anemic subjects. Patients with anemia were significantly older (P = 0.02) and had a higher frequency of cardiovascular diseases, hypertension, kidney disease, diabetes, and cancer (P < 0.05). The frequency of death (anemic: 23.9% vs. nonanemic: 13.8%), ICU admission (anemic: 27.8% vs. nonanemic:14.71%), and ventilator requirement (anemic: 35.93% vs. nonanemic: 20.63%) were significantly higher in anemic patients than in nonanemic patients (P < 0.001). According to the results of regression analysis, after adjusting for significant covariate in the univariable model, anemia was independently associated with mortality (OR: 1.68, 95% CI: 1.10, 2.57, P = 0.01), ventilator requirement (OR: 1.74, 95% CI: 1.19, 2.54, P = 0.004), and the risk of ICU admission (OR: 2.06, 95% CI: 1.46, 2.90, P < 0.001). Conclusion The prevalence of anemia in hospitalized patients with COVID-19 was high and was associated with poor outcomes of COVID-19.

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