Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin
Keyword(s):
ABSTRACT Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (50% effective concentration [EC50] = 120 nM versus 50% cytotoxic concentration [TC50] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin. Occidiofungin has poor gastrointestinal tract absorption properties, supporting future investigations into its potential activities on other enteric parasites.
2015 ◽
Vol 59
(5)
◽
pp. 2479-2487
◽
Keyword(s):
2015 ◽
Vol 59
(9)
◽
pp. 5827-5829
◽
2015 ◽
Vol 60
(1)
◽
pp. 570-579
◽
2013 ◽
Vol 80
(5)
◽
pp. 1595-1601
◽
2015 ◽
Vol 59
(11)
◽
pp. 6939-6945
◽
Keyword(s):