In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model
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ABSTRACT Omadacycline is a novel aminomethylcycline antibiotic with potent activity against Staphylococcus aureus, including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model. The median 24-h area under the concentration-time curve (AUC)/MIC values associated with net stasis and 1-log kill were 21.9 and 57.7, respectively.
2010 ◽
Vol 54
(12)
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pp. 5115-5119
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2011 ◽
Vol 55
(7)
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pp. 3453-3460
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2015 ◽
Vol 59
(6)
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pp. 3252-3256
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2011 ◽
Vol 55
(11)
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pp. 5325-5330
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2019 ◽
Vol 6
(Supplement_2)
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pp. S120-S121
2011 ◽
Vol 55
(11)
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pp. 5004-5009
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