In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species
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ABSTRACT The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.
2016 ◽
Vol 60
(4)
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pp. 2528-2531
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2016 ◽
Vol 60
(6)
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pp. 3813-3816
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2016 ◽
Vol 60
(11)
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pp. 6890-6891
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2015 ◽
Vol 59
(5)
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pp. 2867-2874
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2005 ◽
Vol 49
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pp. 3171-3177
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