Identification of a novel hybrid plasmid encoding KPC-2 and virulence factors in Klebsiella pneumoniae sequence type 11
Keyword(s):
Recent emergence of carbapenem-resistant K. pneumoniae (CRKP) co-harbouring blaKPC-2 and pLVPK-like virulence plasmids represented a novel clinical challenge. In the present study, we characterized a blaKPC-2 and virulence hybrid plasmid, designated as pCRHV-C2244, from a clinical ST11-K64 CRKP strain. pCRHV-C2244 was non-self-transmissible due to the incomplete conjugative elements, but mobilizable together with a conjugative helper. Enhanced virulence and stable maintenance without significant fitness loss in its original host were confirmed in vitro and in vivo.
2020 ◽
2014 ◽
Vol 59
(3)
◽
pp. 1797-1801
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Keyword(s):
2014 ◽
Vol 58
(8)
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pp. 4443-4451
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2021 ◽
2020 ◽
Vol 55
(1)
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pp. 105852
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Keyword(s):
2019 ◽
Vol 6
(Supplement_2)
◽
pp. S60-S60
Keyword(s):