The MSPDBL2 Codon 591 Polymorphism Is Associated with LumefantrineIn VitroDrug Responses in Plasmodium falciparum Isolates from Kilifi, Kenya
2014 ◽
Vol 59
(3)
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pp. 1770-1775
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Keyword(s):
ABSTRACTThe mechanisms of drug resistance development in thePlasmodium falciparumparasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms ofPfmspdbl2for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P= 0.04). The high frequency ofPfmspdbl2codon 591S in Kenya may be driven by the widespread use of lumefantrine in artemisinin combination therapy (Coartem).
2016 ◽
Vol 34
(4)
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pp. 553-557
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2015 ◽
Vol 59
(5)
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pp. 2934-2937
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2015 ◽
Vol 59
(8)
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pp. 4631-4643
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2016 ◽
Vol 54
(6)
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pp. 1500-1511
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