Posaconazole Prophylaxis in Experimental Azole-Resistant Invasive Pulmonary Aspergillosis
2014 ◽
Vol 59
(3)
◽
pp. 1487-1494
◽
Keyword(s):
ABSTRACTWe investigated the efficacy of posaconazole prophylaxis in preventing invasive aspergillosis due to azole-resistantAspergillus fumigatusisolates. Using a neutropenic murine model of pulmonary infection, posaconazole prophylaxis was evaluated using three isogenic clinical isolates, with posaconazole MICs of 0.063 mg/liter (wild type), 0.5 mg/liter (F219I mutation), and 16 mg/liter. A fourth isolate harboring TR34/L98H (MIC of 0.5 mg/liter) was also tested. Posaconazole prophylaxis was effective inA. fumigatuswith posaconazole MICs of ≤0.5 mg/liter, where 100% survival was reached. However, breakthrough infection was observed in mice infected with the isolate for which the posaconazole MIC was >16 mg/liter.
2009 ◽
Vol 53
(6)
◽
pp. 2613-2615
◽
2006 ◽
Vol 50
(10)
◽
pp. 3464-3466
◽
2012 ◽
Vol 57
(1)
◽
pp. 579-585
◽
Keyword(s):
2004 ◽
Vol 48
(5)
◽
pp. 1908-1911
◽
2013 ◽
Vol 57
(12)
◽
pp. 6284-6289
◽