Mutations of the Helicobacter pyloriGenes rdxA and pbp1 Cause Resistance against Metronidazole and Amoxicillin
2001 ◽
Vol 45
(3)
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pp. 962-965
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Keyword(s):
ABSTRACT To investigate amoxicillin and metronidazole resistance ofHelicobacter pylori, we compared putative resistance genes between resistant strains obtained in vitro and their sensitive parent strain. All metronidazole-resistant strains hadrdxA mutations, and an amoxicillin-resistant strain hadpbp1 and pbp2 mutations. By transforming PCR products of these mutated genes into antibiotic-sensitive strains, we showed that rdxA null mutations were sufficient for metronidazole resistance, while pbp1mutations contributed to amoxicillin resistance of H. pylori.
2000 ◽
Vol 44
(8)
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pp. 2133-2142
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2009 ◽
Vol 53
(5)
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pp. 1884-1891
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2006 ◽
Vol 50
(9)
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pp. 3062-3069
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2004 ◽
Vol 53
(11)
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pp. 1123-1128
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1998 ◽
Vol 12
(4)
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pp. 295-298
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1995 ◽
Vol 41
(8)
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pp. 746-749
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2014 ◽
Vol 63
(5)
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pp. 703-709
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1997 ◽
Vol 41
(12)
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pp. 2602-2605
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Keyword(s):