scholarly journals Surveillance for Antiviral-Agent-Resistant Herpes Simplex Virus in the General Population with Recurrent Herpes Labialis

2002 ◽  
Vol 46 (9) ◽  
pp. 3042-3044 ◽  
Author(s):  
Teresa H. Bacon ◽  
Ron J. Boon ◽  
Margaret Schultz ◽  
Cheryl Hodges-Savola
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
General Population ◽  
Population Survey ◽  
Antiviral Agents ◽  
Antiviral Agent ◽  
The United States ◽  
Herpes Labialis ◽  
Recurrent Herpes ◽  
Simplex Virus

ABSTRACT In a general population survey in the United States, the prevalence of antiviral-agent-resistant herpes simplex virus was very low among more than 1,000 isolates from individuals with an episode of recurrent herpes labialis not treated with topical antiviral agents. Two isolates had borderline resistance to acyclovir (0.2%), and all were susceptible to penciclovir.

scholarly journals Antiviral Agents for the Prevention and Treatment of Herpes Simplex Virus Type-1 Infection in Clinical Oncology: A Network Meta-Analysis

2020 ◽  
Vol 17 (23) ◽  
pp. 8891
Author(s):  
Farah Wasim Aribi Al-Zoobaee ◽  
Loo Yee Shen ◽  
Sajesh K. Veettil ◽  
Divya Gopinath ◽  
Mari Kannan Maharajan ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Viral Infections ◽  
Meta Analysis ◽  
Antiviral Agents ◽  
Antiviral Agent ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Assessment Development ◽  
Simplex Virus

Cancer therapy may be complicated and compromised by viral infections, including oral herpes simplex virus (HSV) infection. This network meta-analysis aimed to identify the best antiviral agent to prevent or treat oral HSV infection in patients being treated for cancer. A search was conducted for trials published since inception until the 10th of May 2020 in MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials. A network meta-analysis was performed on the data from randomized controlled trials that assessed antiviral agents for preventive or therapeutic activity vs. placebo, no treatment or any other active intervention in patients being treated for cancer. The agents were ranked according to their effectiveness in the prevention of oral HSV using surface under the cumulative ranking (SUCRA). Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to assess the certainty of the evidence. In total, 16 articles were included. The pooled relative risk (RR) to develop oral HSV infection in the acyclovir group was 0.17 (95% CI: 0.10, 0.30), compared to 0.22 (95% CI: 0.06, 0.77) in the valacyclovir group. Acyclovir ranked highest for the prevention of oral HSV followed by valacyclovir. Subgroup analysis with different acyclovir regimens revealed that the best regimens in terms of HSV-1 prevention were 750 mg/m2 acyclovir administered intravenously followed by 1600 mg per day orally. Acyclovir (250 mg/m2 per day) administered intravenously was the least effective against the prevention of oral HSV.

Detection of herpes simplex virus DNA in the peripheral blood during acute recurrent herpes labialis

1992 ◽  
Vol 26 (4) ◽  
pp. 594-598 ◽  
Author(s):  
Sylvia L. Brice ◽  
Stephen S. Stockert ◽  
Joy D. Jester ◽  
J. Clark Huff ◽  
James D. Bunker ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peripheral Blood ◽  
Herpes Labialis ◽  
Recurrent Herpes ◽  
Simplex Virus

scholarly journals Herpes simplex virus type I–infected disorders alter the balance between Treg and Th17 cells in recurrent herpes labialis patients

2020 ◽  
Vol 34 ◽  
pp. 205873842093309
Author(s):  
Xian-Xian Mei ◽  
Shan-Shan Lei ◽  
Li Xu ◽  
Shan Wu ◽  
Huan-peng Gu ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Healthy Volunteers ◽  
Th17 Cells ◽  
Treg Cells ◽  
Protein Microarrays ◽  
Type I ◽  
Herpes Labialis ◽  
Recurrent Herpes ◽  
Simplex Virus

Recurrent herpes labialis (RHL) is a common skin disease that is often caused by herpes simplex virus type I (HSV-1), but its immunology and pathogenesis remain unclear. The balance of Th17/Treg cells is crucial for maintaining immune homeostasis. This study aimed to investigate whether the balance of Th17/Treg cells and related cytokines may be a determinant occurrence in patients with RHL. This is a clinical experimental research based on clinical observation and analysis. We collected RHL patients from the outpatient clinic of the Department of Dermatology of Zhejiang Chinese Medical University (Hangzhou, China) in 2017, conducted questionnaire survey and signed informed consent. Peripheral blood was collected from 30 patients with RHL and 30 healthy volunteers. Flow cytometry was used to detect the percentages of Treg cells and Th17 cells. Protein microarrays coated with 20 cytokines related to T-cell subsets were performed. Enzyme-linked immunosorbent assay (ELISA) assay was conducted to further verify the expression levels of the cytokines that were screened by protein microarrays. Percentages of Th17/Treg cells in peripheral blood of RHL patients were significantly increased compared to those in healthy volunteers. The fold changes of GM-CSF, IL-4, TGF-β, IL-12, IL-10, IL-17F, and TNF-α were significantly increased compared with healthy volunteers. In addition, the expression of IL-4, IL-10, and TGF-β in the serum of RHL patients increased significantly. Our results indicated an imbalance of Th17/Treg cells in RHL, and this imbalance is probably an important factor in the occurrence, development, and recovery of RHL.

scholarly journals Virology and Histopathology of the Trigeminal Ganglia of Americans and Japanese

1978 ◽  
Vol 5 (4) ◽  
pp. 425-430 ◽  
Author(s):  
K.G. Warren ◽  
Z. Wroblewska ◽  
H. Okabe ◽  
S.M. Brown ◽  
D.H. Gilden ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Mononuclear Cell ◽  
Cell Infiltration ◽  
Trigeminal Ganglia ◽  
Herpes Labialis ◽  
Mononuclear Cell Infiltration ◽  
Recurrent Herpes ◽  
The Difference ◽  
Simplex Virus

SUMMARY:Herpes simplex virus in the trigeminal ganglia of humans was studied in Philadelphia, Pennsylvania, United States of A merica, and in Kyoto, Japan. The prevalence of recurrent herpes labialis and of clinically latent herpes simplex virus within trigeminal ganglia was determined in inhabitants of the two cities. In addition, a comparison was made of the prevalence of mononuclear cell infiltration in the trigeminal ganglia of Americans and Japanese. Recurrent herpes labialis was found to be significantly less common in the Japanese city than in the American city. Herpes simplex virus was rescued less commonly from the trigeminal ganglia of cadavers in Japan than in America. The difference was significant. The frequency of mononuclear cell infiltration in the trigeminal ganglia of Americans and Japanese is not significantly different. These observations, as well as previously reported serological studies, suggest that despite the ubiquitous nature of herpes simplex virus in A merica and Japan, the Japanese have less clinically overt desease caused by this virus.

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