scholarly journals Relative Bioavailability of Three Newly Developed Albendazole Formulations: a Randomized Crossover Study with Healthy Volunteers

2004 ◽  
Vol 48 (3) ◽  
pp. 1051-1054 ◽  
Author(s):  
I. M. Rigter ◽  
H. G. Schipper ◽  
R. P. Koopmans ◽  
H. J. M. van Kan ◽  
H. W. Frijlink ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Plasma Concentrations ◽  
Relative Bioavailability ◽  
Polysorbate 80 ◽  
Albendazole Sulfoxide ◽  
Randomized Crossover Study

ABSTRACT This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-β-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.

Bioavailability of Three Commercial Preparations of Ibuprofen 600 mg

1988 ◽  
Vol 16 (1) ◽  
pp. 44-49 ◽  
Author(s):  
E. Källström ◽  
M. Heikinheimo ◽  
H. Quiding
Keyword(s):  
Single Dose ◽  
Plasma Concentration ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Plasma Concentrations ◽  
Analgesic Efficacy ◽  
Relative Bioavailability ◽  
Maximum Plasma ◽  
The Mean ◽  
Extent Of Absorption

The pharmacokinetic variables of ibuprofen 600 mg were investigated after administration of Brufen and compared to administration of Burana and Ibumetin. The investigation was carried out as a randomized single-dose crossover study in 17 healthy volunteers. The mean maximum plasma concentrations of ibuprofen were 58, 45 and 54 μg/ml after administration of Brufen, Burana and Ibumetin, respectively, the time to reach this being 1.4, 2.1 and 1.6 h, respectively, after administration. The differences between Brufen and Burana were significant. The relative bioavailability was very similar between Brufen and Burana but about 8% lower for Ibumetin and this difference between Brufen and Ibumetin was significant. Thus, different brands of ibuprofen may not be pharmacokinetically interchangeable and the results show that Brufen is superior to either Burana or Ibumetin when considering both the rate and extent of absorption. These findings are clinically interesting since a high and early plasma concentration of ibuprofen seems to be related to increased analgesic efficacy.

Pharmacokinetics and Safety of Coadministered Oseltamivir and Rimantadine in Healthy Volunteers: An Open-Label, Multiple-Dose, Randomized, Crossover Study

2012 ◽  
Vol 52 (8) ◽  
pp. 1255-1264 ◽  
Author(s):  
Georgina Cirrincione-Dall ◽  
Barbara J. Brennan ◽  
Rosa M. Ballester-Sanchis ◽  
Mercidita T. Navarro ◽  
Brian E. Davies
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Multiple Dose ◽  
Open Label ◽  
Randomized Crossover Study

scholarly journals Pharmacokinetics of DFN-15, a Novel Oral Solution of Celecoxib, Versus Celecoxib 400-mg Capsules: A Randomized Crossover Study in Fasting Healthy Volunteers

2017 ◽  
Vol 37 (10) ◽  
pp. 937-946 ◽  
Author(s):  
Arindam Pal ◽  
Srinivas Shenoy ◽  
Anirudh Gautam ◽  
Sagar Munjal ◽  
Jing Niu ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Oral Solution ◽  
Randomized Crossover Study

scholarly journals Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Consumption of Polyphenol Rich Curry in the Polyspice Study

2018 ◽  
Author(s):  
Sumanto Haldar ◽  
Sze Han Lee ◽  
Jun Jie Tan ◽  
Siok Ching Chia ◽  
Christiani Jeyakumar Henry ◽  
...  
Keyword(s):  
Crossover Study ◽  
Phenolic Acids ◽  
Cinnamic Acid ◽  
Phenylacetic Acid ◽  
Plasma Concentrations ◽  
The Other ◽  
High Dose ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Randomized Crossover Study

Spices rich in polyphenols are metabolized to a convergent group of phenolic acids. We conducted a dose-exposure nutrikinetic study to investigate associations between mixed spices intake and plasma concentrations of selected, unconjugated phenolic acids. In a randomized crossover study, 20 Chinese males consumed a curry meal containing 0 g, 6 g, and 12 g of mixed spices. Postprandial blood was drawn up to 7 h at regular intervals and plasma phenolic acids were quantified via LC-MS/MS. Cinnamic acid (CNA, p < 0.0001) and phenylacetic acid (PAA, p < 0.0005) concentrations were significantly increased with mixed spices consumption, although none of the other measured phenolic acids differ significantly between treatments. CNA displayed a high dose-exposure association (R2 > 0.8, p < 0.0001). The adjusted mean AUC0-7 h for CNA during the 3 increasing doses were 8.4 ± 3.4, 376.1 ± 104.7 and 875.7 ± 291.9 nM·h respectively. Plasma CNA concentration may be used as a biomarker of spice intake.

scholarly journals Comparative single-dose bioavailability study of two 10 mg Zolpidem tablet formulations in healthy volunteers

2019 ◽  
Vol 65 (01) ◽  
pp. 11-17
Author(s):  
Dimce Zafirov ◽  
Jasmina Trojacanec ◽  
Dragica Zendelovska ◽  
Nikola Kolovcevski ◽  
Bojan Labachevski
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Plasma Concentrations ◽  
Bioequivalence Study ◽  
Relative Bioavailability ◽  
Serious Adverse Events ◽  
Test Formulation ◽  
Single Oral Administration ◽  
Hypnotic Agent ◽  
Bioavailability Study

Zolpidem is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, pyrrolopyrazines, pyrazolopyrimidines or other drugs with known hypnotic properties. Zolpidem as conventional tablets is used as a hypnotic agent in the short-term management of insomnia, generally for periods not exceeding 7–10 days in duration. The objective of this study was to evaluate and compare the relative bioavailability, and therefore the bioequivalence of Zolpidem 10 mg test formulation versus a reference Zolpidem 10 mg formulation, following a single dose administration under fasting conditions The study was a single center, open, single dose, randomized, two - way crossover study in healthy male volunteers with a wash - out period of one week between study periods. Twenty-eight male healthy volunteers, aged 20-49 years were included into study. Blood samples for determination of zolpidem plasma concentrations were withdraw at 0 (pre-drug administration), 0.33, 0.66, 1, 1.33, 1.66, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, 12, 16 and 24 hours post-drug. The zolpidem concentrations in plasma were determined with HPLC, using fluorescence detection. The test formulation of zolpidem, dosed at 10 mg is bioequivalent for primary zolpidem parameters (Cmax, AUC0-t and AUC0-∞) to the reference formulation after a single oral administration of 10 mg zolpidem. Both medications are well tolerated with no serious adverse events. Thus, in view of the clinical use, both formulations are exchangeable without restrictions. Keywords: Zolpidem, bioavailability, bioequivalence study, single-dose

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