scholarly journals Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion Pathway

2019 ◽  
pp. 163-171 ◽  
Author(s):  
Sujeet Bhoite ◽  
Nani van Gerven ◽  
Matthew R. Chapman ◽  
Han Remaut
Keyword(s):  
Type Viii ◽  
Secretion Pathway ◽  
Amyloid Assembly

Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion Pathway

2019 ◽  
pp. 163-171 ◽  
Author(s):  
Sujeet Bhoite ◽  
Nani Van Gerven ◽  
Matthew R. Chapman ◽  
Han Remaut
Keyword(s):  
Type Viii ◽  
Secretion Pathway ◽  
Amyloid Assembly

Targeting Insulin Amyloid Assembly by Aminosugars and Their Derivatives

2011 ◽  
Vol 18 (6) ◽  
pp. 588-593 ◽  
Author(s):  
V. Nagaveni ◽  
M. Sravani ◽  
S. Prabhakar ◽  
B. Sreedhar ◽  
M. Vairamani
Keyword(s):  
Amyloid Assembly

scholarly journals Molecular Epidemiology and Antifungal Susceptibility of Trichophyton Isolates in Greece: Emergence of Terbinafine-Resistant Trichophytonmentagrophytes Type VIII Locally and Globally

2021 ◽  
Vol 7 (6) ◽  
pp. 419
Author(s):  
Maria Siopi ◽  
Ioanna Efstathiou ◽  
Konstantinos Theodoropoulos ◽  
Spyros Pournaras ◽  
Joseph Meletiadis
Keyword(s):  
Molecular Epidemiology ◽  
Antifungal Susceptibility ◽  
Reference Method ◽  
Cross Resistance ◽  
Squalene Epoxidase ◽  
In Vitro Susceptibility ◽  
Type Viii ◽  
In Vitro Antifungal Susceptibility ◽  
Resistance Rates

Trichophyton isolates with reduced susceptibility to antifungals are now increasingly reported worldwide. We therefore studied the molecular epidemiology and the in vitro antifungal susceptibility patterns of Greek Trichophyton isolates over the last 10 years with the newly released EUCAST reference method for dermatophytes. Literature was reviewed to assess the global burden of antifungal resistance in Trichophyton spp. The in vitro susceptibility of 112 Trichophyton spp. molecularly identified clinical isolates (70 T. rubrum, 24 T. mentagrophytes, 12 T. interdigitale and 6 T. tonsurans) was tested against terbinafine, itraconazole, voriconazole and amorolfine (EUCAST E.DEF 11.0). Isolates were genotyped based on the internal transcribed spacer (ITS) sequences and the target gene squalene epoxidase (SQLE) was sequenced for isolates with reduced susceptibility to terbinafine. All T. rubrum, T. interdigitale and T. tonsurans isolates were classified as wild-type (WT) to all antifungals, whereas 9/24 (37.5%) T. mentagrophytes strains displayed elevated terbinafine MICs (0.25–8 mg/L) but not to azoles and amorolfine. All T. interdigitale isolates belonged to ITS Type II, while T. mentagrophytes isolates belonged to ITS Type III* (n = 11), VIII (n = 9) and VII (n = 4). All non-WT T. mentagrophytes isolates belonged to Indian Genotype VIII and harbored Leu393Ser (n = 5) and Phe397Leu (n = 4) SQLE mutations. Terbinafine resistance rates ranged globally from 0–44% for T. rubrum and 0–76% for T. interdigitale/T. mentagrophytes with strong endemicity. High incidence (37.5%) of terbinafine non-WT T. mentagrophytes isolates (all belonging to ITS Type VIII) without cross-resistance to other antifungals was found for the first time in Greece. This finding must alarm for susceptibility testing of dermatophytes at a local scale particularly in non-responding dermatophytoses.

scholarly journals Kinetic Intermediates in Amyloid Assembly

2014 ◽  
Vol 136 (43) ◽  
pp. 15146-15149 ◽  
Author(s):  
Chen Liang ◽  
Rong Ni ◽  
Jillian E. Smith ◽  
W. Seth Childers ◽  
Anil K. Mehta ◽  
...  
Keyword(s):  
Amyloid Assembly ◽  
Kinetic Intermediates

scholarly journals Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus

ACS Omega ◽  
2021 ◽  
Author(s):  
Zahra Najarzadeh ◽  
Janni Nielsen ◽  
Azad Farzadfard ◽  
Vita Sereikaite ◽  
Kristian Strømgaard ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Human Fibrinogen ◽  
Amyloid Assembly

PuIO, a component of the pullulanase secretion pathway of Klebsiella oxytoca, correctly and efficiently processes gonococcal type IV prepilin in Escherichia coli

1992 ◽  
Vol 6 (14) ◽  
pp. 1887-1894 ◽  
Author(s):  
Bruno Dupuy ◽  
Muhamed-Kheir Taha ◽  
Odile Possot ◽  
Christian Marchal ◽  
Anthony P. Pugsley
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Oxytoca ◽  
Secretion Pathway ◽  
Type Iv
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