We report the draft genome sequence of the multidrug-resistant Escherichia coli strain PTA A1517-5, isolated from a wastewater treatment plant in Costa Rica. The genome consists of 4,927,375 bp with a GC content of 50.57% and a total of 4,853 genes. This strain harbors bla
CTX-M-115, bla
CMY-2, aminoglycoside, tetracycline, and sulfonamide resistance genes.