scholarly journals Mycobacterial induction of activated killer cells: possible role of tyrosine kinase activity in interleukin-2 receptor alpha expression.

1992 ◽  
Vol 60 (7) ◽  
pp. 2843-2849 ◽  
Author(s):  
D K Blanchard ◽  
S McMillen ◽  
S L Hoffman ◽  
J Y Djeu
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Interleukin 2 ◽  
Tyrosine Kinase Activity ◽  
Killer Cells ◽  
Receptor Alpha ◽  
Interleukin 2 Receptor

Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro

Cytokine ◽  
1991 ◽  
Vol 3 (5) ◽  
pp. 428-438 ◽  
Author(s):  
Dennis F. Michiel ◽  
Gonzalo G. Garcia ◽  
Gerald A. Evans ◽  
William L. Farrar
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Interleukin 2 ◽  
Receptor Complex ◽  
Tyrosine Kinase Activity ◽  
Interleukin 2 Receptor

The Role of Anaplastic Lymphoma Kinase in Human Cancers

2013 ◽  
Vol 09 (02) ◽  
pp. 149 ◽  
Author(s):  
Alejandro García-Regalado ◽  
Claudia Haydée González-De la Rosa ◽  
◽  
Keyword(s):  
Tyrosine Kinase ◽  
Anaplastic Lymphoma Kinase ◽  
Kinase Activity ◽  
New Drugs ◽  
Tyrosine Kinase Activity ◽  
Mutant Proteins ◽  
Anaplastic Lymphoma ◽  
Attractive Therapeutic Target ◽  
Pathway Inhibition

The anaplastic lymphoma kinase (ALK) is a receptor with tyrosine kinase activity, which regulates the development and maintenance of the nervous system. Mutations or amplification in ALK promote tumorogenesis and progression of diverse types of cancer, which makes it an attractive therapeutic target against cancer diseases. Inhibition of its tyrosine kinase activity with small molecules, such as crizotinib, reveals tumor reversion; however, secondary mutations and amplification of the gene mediate resistance to treatment. In this article, we discuss the emerging role of possible therapeutic targets that could overcome the resistance to ALK inhibition in cancer, such as inhibition of other kinases involved in the pathway, inhibition of ALK mutant proteins through the development of new drugs based on its crystallography, and the use of antibodies against ALK.

The role of interleukin-2 receptor alpha in cancer

10.2741/1631 ◽  
2005 ◽  
Vol 10 (1-3) ◽  
pp. 1462 ◽  
Author(s):  
Deborah, J. Kuhn
Keyword(s):  
Interleukin 2 ◽  
Receptor Alpha ◽  
Interleukin 2 Receptor

Inhibition of Interleukin 2 (IL-2)-stimulated tyrosine kinase activity by leflunomide

1994 ◽  
Vol 41 (S2) ◽  
pp. C279-C282 ◽  
Author(s):  
Daniel A Nikcevich ◽  
Alison Finnegan ◽  
Anita S. -F. Chong ◽  
James W. Williams ◽  
Eric G. Bremer
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Interleukin 2 ◽  
Tyrosine Kinase Activity
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