scholarly journals LiCl treatment releases a nickase implicated in genetic transformation of Streptococcus pneumoniae.

1987 ◽  
Vol 169 (11) ◽  
pp. 4901-4906 ◽  
Author(s):  
T Fujii ◽  
D Naka ◽  
N Toyoda ◽  
H Seto
Keyword(s):  
Streptococcus Pneumoniae ◽  
Genetic Transformation ◽  
Licl Treatment

scholarly journals Natural Genetic Transformation Generates a Population of Merodiploids in Streptococcus pneumoniae

PLoS Genetics ◽  
2013 ◽  
Vol 9 (9) ◽  
pp. e1003819 ◽  
Author(s):  
Calum Johnston ◽  
Stéphanie Caymaris ◽  
Aldert Zomer ◽  
Hester J. Bootsma ◽  
Marc Prudhomme ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Genetic Transformation ◽  
Natural Genetic Transformation

scholarly journals Role of HtrA in the Virulence and Competence of Streptococcus pneumoniae

2004 ◽  
Vol 72 (6) ◽  
pp. 3584-3591 ◽  
Author(s):  
Yasser Musa Ibrahim ◽  
Alison R. Kerr ◽  
Jackie McCluskey ◽  
Tim J. Mitchell
Keyword(s):  
Oxidative Stress ◽  
Streptococcus Pneumoniae ◽  
Genetic Transformation ◽  
Mouse Models ◽  
High Temperatures ◽  
Virulence Factors ◽  
Virulence Factor ◽  
Wild Type ◽  
Major Virulence Factor

ABSTRACT HtrA is a major virulence factor of Streptococcus pneumoniae (the pneumococcus). Deletion of the gene for HtrA from strain D39 of the pneumococcus completely abolished its virulence in mouse models of pneumonia and bacteremia, while the virulence of a second strain (TIGR4) was dramatically reduced. HtrA-negative mutants induced much less inflammation in the lungs during pneumonia than the wild type. HtrA is involved in the ability of the pneumococcus to grow at high temperatures, to resist oxidative stress, and to undergo genetic transformation. The expression and cellular location of several known virulence factors of the pneumococcus were not affected by the lack of HtrA.

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