Iron-Dependent Transcription of the frpB Gene ofHelicobacter pylori Is Controlled by the Fur Repressor Protein
2001 ◽
Vol 183
(16)
◽
pp. 4932-4937
◽
Keyword(s):
ABSTRACT We have overexpressed and purified the Helicobacter pylori Fur protein and analyzed its interaction with the intergenic regions of divergent genes involved in iron uptake (frpB and ceuE) and oxygen radical detoxification (katA and tsaA). DNase I footprint analysis showed that Fur binds specifically to a high-affinity site overlapping theP frpB promoter and to low-affinity sites located upstream from promoters within both thefrpB-katA and ceuE-tsaA intergenic regions. Construction of an isogenic fur mutant indicated that Fur regulates transcription from the P frpB promoter in response to iron. In contrast, no effect by either Fur or iron was observed for the other promoters.
2003 ◽
Vol 185
(16)
◽
pp. 4748-4754
◽
1987 ◽
Vol 65
(1)
◽
pp. 18-22
◽
Keyword(s):
1980 ◽
Vol 58
(10)
◽
pp. 969-977
◽
Keyword(s):
1986 ◽
Vol 261
(14)
◽
pp. 6230-6233
◽
1992 ◽
Vol 262
(2)
◽
pp. G244-G248
◽
Keyword(s):
Keyword(s):