PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A
2004 ◽
Vol 186
(2)
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pp. 575-579
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Keyword(s):
Lipid A
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ABSTRACT Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The mutations responsible for this phenotype were mapped to a two-component signal transduction system similar to PmrAB of Salmonella enterica serovar Typhimurium. Lipid A of these mutants contained aminoarabinose, an inducible modification that is associated with polymyxin resistance. Thus, P. aeruginosa possesses a mechanism that induces resistance to cationic antimicrobial peptides in response to environmental conditions.
2003 ◽
Vol 50
(1)
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pp. 205-217
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2013 ◽
Vol 57
(8)
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pp. 3875-3882
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1999 ◽
Vol 181
(21)
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pp. 6840-6843
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2015 ◽
Vol 59
(7)
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pp. 3789-3799
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2010 ◽
Vol 54
(8)
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pp. 3372-3382
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2021 ◽
2015 ◽
Vol 59
(9)
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pp. 5377-5387
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