Ability of Laboratories To Detect Emerging Antimicrobial Resistance: Proficiency Testing and Quality Control Results from the World Health Organization's External Quality Assurance System for Antimicrobial Susceptibility Testing

AbstractCampylobacter spp. are food- and water borne pathogens. While rather accurate estimates for these pathogens are available in industrialized countries, a lack of diagnostic capacity in developing countries limits accurate assessments of prevalence in many regions. Proficiency in the identification and susceptibility testing of these organisms is critical for surveillance and control efforts. The aim of the study was to assess performance for identification and susceptibility testing of thermo-tolerant Campylobacter among laboratories participating in the World Health Organization (WHO) Global Foodborne Infections Network (GFN) External Quality Assurance System (EQAS) over a nine year period.Participants (primarily national level laboratories) were encouraged to self-evaluate performance as part of continuous quality improvement.The ability to correctly identify Campylobacter spp. varied by year and ranged from 61.9 % (2008) to 90.7 % (2012), and the ability to correctly perform antimicrobial susceptibility testing (AST) for Campylobacter spp. appeared to steadily increase from 91.4 % to 93.6 % in the test period (2009-2012).Poorest performance (60.0 % correct identification and 86.8 % correct AST results) was observed in African laboratories.Overall, approximately 10 % of laboratories reported either an incorrect identification or antibiogramme. As most participants were (supra)-national reference laboratories, these data raise significant concerns regarding capacity and proficiency at the local, clinical level. Addressing these diagnostic challenges is critical for both patient level management and broader surveillance and control efforts.

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Proficiency of WHO Global Foodborne Infections Network External Quality Assurance System Participants in Identification and Susceptibility Testing of Thermotolerant Campylobacter spp. from 2003 to 2012

Journal of Clinical Microbiology ◽

10.1128/jcm.01066-18 ◽

2018 ◽

Vol 56 (11) ◽

Cited By ~ 5

Author(s):

Susanne Karlsmose Pedersen ◽

Jaap A. Wagenaar ◽

Håkan Vigre ◽

Louise Roer ◽

Matthew Mikoleit ◽

...

Keyword(s):

Quality Assurance ◽

Susceptibility Testing ◽

External Quality Assurance ◽

World Health ◽

Quality Assurance System ◽

External Quality ◽

Content Type ◽

Assurance System ◽

And Control ◽

Foodborne Infections

ABSTRACT Campylobacter spp. are foodborne and waterborne pathogens. While rather accurate estimates for these pathogens are available in industrialized countries, a lack of diagnostic capacity in developing countries limits accurate assessments of prevalence in many regions. Proficiency in the identification and susceptibility testing of these organisms is critical for surveillance and control efforts. The aim of the study was to assess performance for identification and susceptibility testing of thermotolerant Campylobacter spp. among laboratories participating in the World Health Organization (WHO) Global Foodborne Infections Network (GFN) External Quality Assurance System (EQAS) over a 9-year period. Participants (primarily national-level laboratories) were encouraged to self-evaluate their performance as part of continuous quality improvement. The ability to correctly identify Campylobacter spp. varied by year and ranged from 61.9% (2008) to 90.7% (2012), and the ability to correctly perform antimicrobial susceptibility testing (AST) for Campylobacter spp. appeared to steadily increase from 91.4% to 93.6% in the test period (2009 to 2012). The poorest performance (60.0% correct identification and 86.8% correct AST results) was observed in African laboratories. Overall, approximately 10% of laboratories reported either an incorrect identification or antibiogram. As most participants were supranational reference laboratories, these data raise significant concerns regarding capacity and proficiency at the local clinical level. Addressing these diagnostic challenges is critical for both patient-level management and broader surveillance and control efforts.

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Notice of Retraction: Innovate in external quality assurance system so as to enhance the development of graduate student education

2011 2nd International Conference on Artificial Intelligence, Management Science and Electronic Commerce (AIMSEC) ◽

10.1109/aimsec.2011.6009841 ◽

2011 ◽

Author(s):

Li-na Gu

Keyword(s):

Quality Assurance ◽

Graduate Student ◽

External Quality Assurance ◽

Quality Assurance System ◽

External Quality ◽

Student Education ◽

Assurance System ◽

Graduate Student Education

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A Comprehensive Review on Current Progressions in Combating The Antimicrobial Resistance

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i2.2023 ◽

2020 ◽

Vol 11 (2) ◽

pp. 1493-1504

Author(s):

Bharatlal Sain ◽

Manohar M ◽

Gowda D V

Keyword(s):

Photodynamic Therapy ◽

Antimicrobial Resistance ◽

Antimicrobial Susceptibility ◽

Biofilm Formation ◽

Susceptibility Testing ◽

Persister Cells ◽

Comprehensive Review ◽

Obligate Intracellular ◽

Competitive Inhibitors ◽

The World

Anti-microbial resistance (AMR) is the ability of a microbe to resist the effect of antibiotics. It has become the most important cause of concern throughout the world. AMR may develop a variety of mechanisms, including resistance, weakness or due to a certain therapeutic failure. The three major causes of resistance were identified to be over usage of anti-microbials, over-prescription, increased agricultural usage. The mechanism which leads to the development of AMR were found to be Metabolic Inactive Persister cells biofilm formation, Swarming, Obligate intracellular microbes, Reduced uptake and efflux pumps, Modification of the antibiotic binding site, Production of competitive inhibitors. Research is still being carried out and few methods successfully delay or inhibit the progress of Resistance namely: Photodynamic therapy, which works on the principle of photosensitization, results in formation of ROS which destroy pathogenic cells, Vaccines, which strengthen the defence system to fight against foreign microorganisms efficiently, Antibiotic adjuvants, work by inhibiting any kind of mechanism related to the resistance increasing the drug’s antibacterial efficiency, Nano antibiotics which acts by interfering with the mechanisms for the development of the resistance and microfluidics give a better understanding of the bacteria and its superior antimicrobial susceptibility testing. Hence, in this review the above mechanisms of antimicrobial resistance as well the latest AMR combating strategies are been discussed.

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The Objectives and Practical Aspects of Quality Assurance System of Higher Education

International Journal of Higher Education ◽

10.5430/ijhe.v9n7p119 ◽

2020 ◽

Vol 9 (7) ◽

pp. 119

Author(s):

Dora H. Ivanova ◽

Olga V. Goray ◽

Nadiia I. Horbachova ◽

Iryna M. Krukovska ◽

Svitlana D. Poplavska

Keyword(s):

Higher Education ◽

Quality Assurance ◽

Education System ◽

Educational Services ◽

Quality Assurance System ◽

The European Union ◽

Higher Education System ◽

Assurance System ◽

The World

Each country in the world has its own individual approaches to the quality assurance system of higher education, so the quality of educational services in each country is different. The developing countries should be guided by the standards and recommendations put forward by the world’s leading countries in the field of the assurance system of higher education in order to improve the quality of education services. The purpose of the scientific investigation is to formulate the objectives and analyze the practical aspects of functioning of the quality assurance system of higher education. In the study’s framework of the practical aspects of the higher education’s quality in European Union’s countries, the methods of general analysis have been used, including comparison and grouping; at the same time, the presentation of statistics is also demonstrated by graphical methods. The practical aspects of quality assurance of higher education in European Union’s countries have been analyzed, which is reflected in the dynamics of the number of students who have received higher education, the structure of higher education degree seeking applicants, the employment rate of graduates who have graduated from higher education institutions (Employment rates of recent graduates), the World University Rankings, the Europe Teaching Rankings, rating of the strength of the higher education system (the QS Higher Education System Strength Rankings). Proposals for ensuring the proper quality of higher education and a high level of educational services to educational institutions of the European Union have been presented.

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