scholarly journals Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3.

1990 ◽  
Vol 64 (2) ◽  
pp. 748-756 ◽  
Author(s):  
M M Falk ◽  
P R Grigera ◽  
I E Bergmann ◽  
A Zibert ◽  
G Multhaup ◽  
...  
Keyword(s):  
Host Cell ◽  
Disease Virus ◽  
Histone H3 ◽  
Foot And Mouth Disease ◽  
Proteolytic Cleavage ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity

Structure ◽  
1996 ◽  
Vol 4 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Stephen Curry ◽  
Elizabeth Fry ◽  
Wendy Blakemore ◽  
Robin Abu Ghazaleh ◽  
Terry Jackson ◽  
...  
Keyword(s):  
Surface Structure ◽  
Host Cell ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Cell Specificity ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Host Cell Selection of Antigenic Variants of Foot-and-Mouth Disease Virus

1989 ◽  
Vol 70 (1) ◽  
pp. 45-57 ◽  
Author(s):  
C. Bolwell ◽  
A. L. Brown ◽  
P. V. Barnett ◽  
R. O. Campbell ◽  
B. E. Clarke ◽  
...  
Keyword(s):  
Host Cell ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Cell Selection ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Selection Of

scholarly journals Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins

Virology ◽  
2007 ◽  
Vol 364 (2) ◽  
pp. 466-474 ◽  
Author(s):  
Miguel Rodríguez Pulido ◽  
Paula Serrano ◽  
Margarita Sáiz ◽  
Encarnación Martínez-Salas
Keyword(s):  
Virus Infection ◽  
Disease Virus ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Foot And Mouth Disease ◽  
Proteolytic Cleavage ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Expansion of host-cell tropism of foot-and-mouth disease virus despite replication in a constant environment

2004 ◽  
Vol 85 (8) ◽  
pp. 2289-2297 ◽  
Author(s):  
Carmen M. Ruiz-Jarabo ◽  
Nonia Pariente ◽  
Eric Baranowski ◽  
Mercedes Dávila ◽  
Gema Gómez-Mariano ◽  
...  
Keyword(s):  
Host Cell ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Jurkat Cells ◽  
Virus Infectivity ◽  
Cell Tropism ◽  
Cellular Environment ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Foot-and-mouth disease virus (FMDV) variants adapted to BHK-21 cells showed an expanded host-cell tropism that extended to primate and human cell lines. Virus replication in human HeLa and Jurkat cells has been documented by titration of virus infectivity, quantification of virus RNA, expression of a virus-specific non-structural antigen, and serial passage of virus in the cells. Parallel serial infections of human Jurkat cells with the same variant FMDVs indicates a strong stochastic component in the progression of infection. Chimeric viruses identified the capsid as a genomic region involved in tropism expansion. These results indicate that, contrary to theoretical predictions, replication of an RNA virus in a constant cellular environment may lead to expansion of cellular tropism, rather than to a more specialized infection of the cellular type to which the virus has been adapted.

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