Divergent Requirements for the MAPKERK Signal Transduction Pathway during Initial Virus Infection of Quiescent Primary B Cells and Disruption of Epstein-Barr Virus Latency by Phorbol Esters
1999 ◽
Vol 73
(10)
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pp. 8913-8916
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Keyword(s):
ABSTRACT Quiescent primary B lymphocytes and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines express components of the extracellular response kinase arm of the mitogen-activated protein kinase (MAPKERK) signal transduction pathway and transmit signals through the pathway when exposed to appropriate stimuli. Although the MAPKERK pathway is activated following infection with EBV, MAPK/ERK kinase (MEK1) activity is not required to drive the proliferation of infected cells. However, MEK1 contributes to EBV latency control.
2008 ◽
Vol 89
(10)
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pp. 2437-2446
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2014 ◽
Vol 15
(22)
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pp. 9835-9839
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1993 ◽
Vol 13
(9)
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pp. 5659-5669
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1999 ◽
Vol 180
(2)
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pp. 215-224
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2001 ◽
Vol 65
(2)
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pp. 561-567
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2000 ◽
Vol 164
(8)
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pp. 4348-4358
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2001 ◽
Vol 69
(10)
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pp. 6217-6224
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2005 ◽
Vol 57
(6)
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pp. 617-623
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