A Human Immunodeficiency Virus Type 1-Infected Individual with Low Viral Load Harbors a Virus Variant That Exhibits an In Vitro RNA Dimerization Defect
2004 ◽
Vol 78
(9)
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pp. 4907-4913
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Keyword(s):
ABSTRACT We investigated the in vitro RNA dimerization properties of the untranslated leader RNA derived from human immunodeficiency virus type 1 variants circulating in an individual with a low viral load and slow disease progression. The leader sequences of these viruses contain highly unusual polymorphisms within the dimerization initiation site (DIS): an insert that abolishes dimerization and a compensatory substitution. The dimerization of leader RNA from late stages of infection is further improved by additional mutations outside the DIS motif that facilitate a secondary structure switch from a dimerization-incompetent to a dimerization-competent RNA conformation.
2003 ◽
Vol 77
(1)
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pp. 291-300
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A Riboswitch Regulates RNA Dimerization and Packaging in Human Immunodeficiency Virus Type 1 Virions
2004 ◽
Vol 78
(19)
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pp. 10814-10819
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1994 ◽
Vol 91
(11)
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pp. 4945-4949
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1995 ◽
Vol 69
(10)
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pp. 6572-6576
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2017 ◽
Vol 15
(10)
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pp. 917-933
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2002 ◽
Vol 76
(3)
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pp. 1015-1024
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2014 ◽
Vol 205
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pp. 91-98
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2005 ◽
Vol 36
(4)
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pp. 382-386
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