scholarly journals Complete Genome Sequence of a Precore-Defective Hepatitis B Virus Genotype D2 Strain Isolated in Bangladesh

2020 ◽  
Vol 9 (11) ◽  
Author(s):  
Md Golzar Hossain ◽  
Md Muket Mahmud ◽  
Md Arifur Rahman ◽  
Sharmin Akter ◽  
K. H. M. Nazmul Hussain Nazir ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Nucleotide Sequence ◽  
Hepatitis B ◽  
Complete Genome Sequence ◽  
Complete Nucleotide Sequence ◽  
Mutational Analysis ◽  
Limited Information ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
B Virus

Hepatitis B virus (HBV) genomic mutations affect viral replication, disease progression, and diagnostic and vaccination efficiency. There is limited information regarding characterization and mutational analysis of HBV isolated in Bangladesh. Here, we report the complete nucleotide sequence of a precore-defective HBV genotype D2 strain isolated in Bangladesh.

scholarly journals Complete Genome Sequence of a Circulating Hepatitis B Virus Genotype C Strain Isolated from a Chronically Infected Patient Identified at an Outdoor Hospital in Bangladesh

2018 ◽  
Vol 6 (9) ◽  
pp. e01601-17 ◽  
Author(s):  
Modhusudon Shaha ◽  
Keshob Chandra Das ◽  
M. Saddam Hossain ◽  
Munira Jahan ◽  
Abu Hashem ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
B Virus ◽  
Genotype C ◽  
Potential Vaccine

ABSTRACT Hepatitis B virus (HBV) causes significant global health problems despite the presence of a potential vaccine. HBV chronic cases are increasing rapidly in developing countries like Bangladesh. Here, we report the complete genome sequence of an HBV genotype C strain isolated from a chronic patient identified at an outdoor hospital section.

scholarly journals Novel Hepatitis B Virus Genotype A Subtyping Assay That Distinguishes Subtype Aa from Ae and Its Application in Epidemiological Studies

2004 ◽  
Vol 78 (14) ◽  
pp. 7575-7581 ◽  
Author(s):  
Izumi Hasegawa ◽  
Yasuhito Tanaka ◽  
Anna Kramvis ◽  
Takanobu Kato ◽  
Fuminaka Sugauchi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clinical Manifestations ◽  
The United States ◽  
Sub Saharan Africa ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Specificity And Sensitivity ◽  
B Virus ◽  
Genotype A

ABSTRACT The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was reported in sub-Saharan Africa, raising the possibility that patients infected with this subtype (HBV/Aa [“a” for African and Asian]) may have different clinical outcomes than other HBV/A isolates (HBV/Ae [“e” for European]). Comparison between 30 HBV/Aa and 30 HBV/Ae isolates indicated that almost all HBV/Ae isolates had G at nucleotide (nt) 1809 and C at nt 1812, whereas HBV/Aa isolates had T1809/T1812. Taking advantage of these two single nucleotide polymorphisms (SNPs), a novel subtype-specific PCR assay in the X/precore/core region was developed. This assay was combined with a restriction fragment length polymorphism assay using BglII in a different region (nt 1984 to 1989), which has a SNP distinguishing HBV/Aa from HBV/Ae, resulting in 100% specificity for the combined assay. Application of the subtyping assay using sera from 109 paid donors in the United States indicated significantly different distributions of HBV/A subtypes among races; African-Americans, Caucasians, and Hispanics had HBV/Ae, whereas Asians had mainly HBV/Aa, suggesting that the HBV/Aa isolates may have been imported by recent immigration from Asia. In conclusion, the specificity and sensitivity of the combined subtyping assay were confirmed, and its usefulness was demonstrated in a practical context.

scholarly journals Molecular Evolution of Hepatitis B Virus Genotype F in Latin America

2021 ◽  
Author(s):  
Jonas Wolf ◽  
Thiago Kastell Mazeto ◽  
Vagner Reinaldo Zingalli Bueno Pereira ◽  
Daniel Simon ◽  
Vagner Ricardo Lunge
Keyword(s):  
Latin America ◽  
Hepatitis B Virus ◽  
Molecular Evolution ◽  
Hepatitis B ◽  
Recent Common Ancestor ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Most Recent Common Ancestor ◽  
B Virus ◽  
Genotype F

Abstract Hepatitis B virus (HBV) genotype F evolution is not completely understood in Latin America. This study aims to evaluate the molecular evolution of HBV-F in Latin America by comparing 224 whole-genome sequences. Bayesian coalescent analysis was performed to estimate the time to the most recent common ancestor. Four main clades were formed dated back between 1245 and 1730. Also, four subclades were identified dated back between 1705 and 1801. HBV-F overall effective population size grew in the 18th century and showed an initial circulation of HBV-F from Venezuela to other countries from Latin America.

scholarly journals Complete nucleotide sequence of hepatitis B virus

1990 ◽  
Vol 18 (15) ◽  
pp. 4587-4587 ◽  
Author(s):  
F. Takemura ◽  
T. Ishii ◽  
N. Fujii ◽  
T. Uchida
Keyword(s):  
Hepatitis B Virus ◽  
Nucleotide Sequence ◽  
Hepatitis B ◽  
Complete Nucleotide Sequence ◽  
B Virus

scholarly journals The complete nucleotide sequence of Hepatitis B virus, subtype adr (SRADR) and phylogenetic analysis

1992 ◽  
Vol 20 (22) ◽  
pp. 6105-6105 ◽  
Author(s):  
Motokazu Mukaide ◽  
Toshiaki Kumazawa ◽  
Akihiko Hoshi ◽  
Ryuji Kawaguchi ◽  
Kazumasa Hikiji
Keyword(s):  
Phylogenetic Analysis ◽  
Hepatitis B Virus ◽  
Nucleotide Sequence ◽  
Hepatitis B ◽  
Complete Nucleotide Sequence ◽  
B Virus ◽  
Virus Subtype

scholarly journals Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B

2006 ◽  
Vol 87 (5) ◽  
pp. 1175-1180 ◽  
Author(s):  
Futoshi Nagasaki ◽  
Hirofumi Niitsuma ◽  
Julieta G. Cervantes ◽  
Masanori Chiba ◽  
Shan Hong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genetic Distances ◽  
The Philippines ◽  
Nucleotide Sequences ◽  
Virus Genotype ◽  
Hbv Genotype ◽  
Phylogenetic Tree Analysis ◽  
Entire Genome ◽  
B Virus

The entire nucleotide sequences were determined for hepatitis B virus (HBV) genotype B (HBV/B) genomes extracted from five patients in the Philippines and designated GenBank AB219426, AB219427, AB219428, AB219429 and AB219430. The serotype of the first four isolates was ayw and that of GenBank AB219430 was adw. Divergences of entire sequences were 1·0–2·0 % between the first four isolates and 3·8–4·2 % between these four and GenBank AB219430. Phylogenetic-tree analysis revealed that, worldwide, HBV/B comprises five subgenotypes: B1, B2, B3, B4 and the new Philippines group, designated B5. Divergences of the entire genome sequences between four isolates in subgenotype B5 and isolates from other countries (subgenotypes) were 4·4–4·8 % with Vietnam (B4), 2·9–3·5 % with Indonesia (B3), 4·7–5·1 % with China (B2) and 5·4–6·0 % with Japan (B1). Similarly, GenBank AB219430 showed the lowest divergences: 3·4 % with the isolate from Indonesia (B3), 5·0 % with Vietnam (B4), 5·4 % with China (B2) and 6·1 % with Japan (B1). This is the first report of entire nucleotide sequences of HBV/B from the Philippines and the results show that these sequences belong to a new subgenotype, B5. The present study identified that HBV/B isolates throughout the world are divided genetically into five subgenotypes, the relationships between geographical distances and the genetic distances of HBV/B being well-correlated.

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