scholarly journals Complete Genome Sequence of Herpes Simplex Virus 1 Strain MacIntyre

2019 ◽  
Vol 8 (37) ◽  
Author(s):  
Xiaoli Jiao ◽  
Hongyan Sui ◽  
Christopher Lyons ◽  
Bao Tran ◽  
Brad T. Sherman ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Single Molecule ◽  
Herpes Simplex Virus Type ◽  
Complete Sequence ◽  
Genetic Determinants ◽  
Sequencing Technology ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

Herpes simplex virus type 1 (HSV-1) strain MacIntyre has a severe defect in the anterograde spread after replication in the nucleus. To better understand and identify the genetic determinants that lead to the unique phenotypes of the MacIntyre strain, we sequenced its genome with PacBio single-molecule real-time sequencing technology and resolved the complete sequence.

scholarly journals Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae

2019 ◽  
Vol 8 (39) ◽  
Author(s):  
Xiaoli Jiao ◽  
Hongyan Sui ◽  
Christopher Lyons ◽  
Bao Tran ◽  
Brad T. Sherman ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Single Molecule ◽  
Complete Sequence ◽  
Wild Type ◽  
Genetic Determinants ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Highly Virulent ◽  
Hsv 1

Herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent and relatively neuroinvasive in animal models compared with other wild-type HSV-1 strains. To identify the genetic determinants that lead to the unique phenotypes of the McKrae strain, we sequenced its genome with PacBio single-molecule real-time (SMRT) technology and resolved the complete sequence.

scholarly journals Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2988
Author(s):  
Samir Mohamed Awad ◽  
Shima Mahmoud Ali ◽  
Yara Essam Mansour ◽  
Samar Said Fatahala
Keyword(s):  
Drug Resistance ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Side Effects ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Hsv 1

Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir.

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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