scholarly journals Comparative Genomics of Mycobacterium avium Complex Reveals Signatures of Environment-Specific Adaptation and Community Acquisition

mSystems ◽  
2021 ◽  
Author(s):  
Eric C. Keen ◽  
JooHee Choi ◽  
Meghan A. Wallace ◽  
Michelle Azar ◽  
Carlos R. Mejia-Chew ◽  
...  
Keyword(s):  
Comparative Genomics ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Natural Environments ◽  
Emerging Pathogens ◽  
Content Type ◽  
Specific Adaptation

Members of the Mycobacterium avium complex (MAC), a group of mycobacteria encompassing M. avium and its closest relatives, are omnipresent in natural environments and emerging pathogens of humans and animals. MAC infections are difficult to treat, sometimes fatal, and increasingly common.

scholarly journals Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance

2020 ◽  
Vol 64 (7) ◽  
Author(s):  
Mike Marvin Ruth ◽  
Lian J. Pennings ◽  
Valerie A. C. M. Koeken ◽  
Jodie A. Schildkraut ◽  
Aria Hashemi ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Efflux Pump ◽  
Ex Vivo ◽  
Plasma Concentrations ◽  
Intracellular Growth ◽  
Macrophage Infection ◽  
Efflux Pump Inhibitor ◽  
Content Type ◽  
Time Kill

ABSTRACT Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) is challenging partly due to high efflux pump expression. Thioridazine might block these efflux pumps. We explore the efficacy of thioridazine against M. avium isolates using MICs, time-kill combination assays, ex vivo macrophage infection assays, and efflux assays. Thioridazine is bactericidal against M. avium, inhibits intracellular growth at 2× MIC, and blocks ethidium bromide efflux. However, its toxicity and low plasma concentrations make it unlikely to add efficacy to MAC-PD therapy.

scholarly journals Intermittent Treatment with Azithromycin and Ethambutol for Noncavitary Mycobacterium avium Complex Pulmonary Disease

2019 ◽  
Vol 64 (1) ◽  
Author(s):  
Seong Mi Moon ◽  
In Young Yoo ◽  
Hee Jae Huh ◽  
Nam Yong Lee ◽  
Byung Woo Jhun
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Odds Ratio ◽  
Mycobacterium Avium Complex ◽  
Adjusted Odds Ratio ◽  
Sputum Smear ◽  
Intermittent Treatment ◽  
Content Type ◽  
Sputum Culture Conversion ◽  
Culture Conversion

ABSTRACT We evaluated the efficacy of intermittent azithromycin and ethambutol therapy for noncavitary Mycobacterium avium complex pulmonary disease (MAC-PD). Twenty-nine (76%) of 38 patients achieved sputum culture conversion after 12 months of treatment, and sputum smear positivity was an independent factor for failure to achieve culture conversion (adjusted odds ratio, 26.7; 95% confidence interval, 2.1 to 339.9; P = 0.011). Intermittent azithromycin and ethambutol may be an optional treatment regimen for noncavitary MAC-PD.

scholarly journals Recurrence of Disseminated Mycobacterium avium Complex Disease in a Patient with Anti-Gamma Interferon Autoantibodies by Reinfection

2015 ◽  
Vol 53 (4) ◽  
pp. 1436-1438 ◽  
Author(s):  
Tomoyasu Nishimura ◽  
Yukiko Fujita-Suzuki ◽  
Makoto Yonemaru ◽  
Kiyofumi Ohkusu ◽  
Takuro Sakagami ◽  
...  
Keyword(s):  
Disease Activity ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Complex Disease ◽  
Gamma Interferon ◽  
Igg Antibody ◽  
Content Type ◽  
Lipid Antigens ◽  
Antibody Titers ◽  
Mycobacterium Avium Complex Disease

We report a case of recurrent disseminatedMycobacterium aviumcomplex (DMAC) disease with anti-gamma interferon autoantibodies. To our knowledge, this is the first reported case caused by reinfection with a separate isolate ofM. avium. DMAC disease activity was monitored using serum IgG antibody titers against lipid antigens extracted from a MAC strain.

scholarly journals In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Barbara A. Brown-Elliott ◽  
Julie V. Philley ◽  
David E. Griffith ◽  
Foram Thakkar ◽  
Richard J. Wallace
Keyword(s):  
Cytochrome P450 ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Susceptibility Testing ◽  
Multidrug Resistant ◽  
Broth Microdilution ◽  
In Vitro Susceptibility ◽  
Content Type ◽  
In Vitro Susceptibility Testing

ABSTRACT We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

scholarly journals Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease

2015 ◽  
Vol 59 (8) ◽  
pp. 4994-4996 ◽  
Author(s):  
Won-Jung Koh ◽  
Byeong-Ho Jeong ◽  
Kyeongman Jeon ◽  
Hye Yun Park ◽  
Su-Young Kim ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Lung Disease ◽  
Clinical Efficacy ◽  
Mycobacterium Avium ◽  
Initial Treatment ◽  
Mycobacterium Avium Complex ◽  
Intermittent Therapy ◽  
Content Type ◽  
Negative Culture

ABSTRACTIntermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectaticMycobacterium aviumcomplex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.

Polymicrobial Intracerebral Abscess Growing Achromobacter Xylosoxidans and Mycobacterium Avium Complex

2020 ◽  
Author(s):  
Juliana Rotter ◽  
Christopher S. Graffeo ◽  
Hannah E. Gilder ◽  
Lucas P. Carlstrom ◽  
Avital Perry ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Achromobacter Xylosoxidans ◽  
Intracerebral Abscess
Sign in / Sign up

Export Citation Format

Share Document