scholarly journals Identification of Hemagglutinin Mutations Caused by Neuraminidase Antibody Pressure

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Fei Wang ◽  
Zhimin Wan ◽  
Yajuan Wang ◽  
Jinsen Wu ◽  
Hui Fu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Sialic Acid ◽  
Host Cell ◽  
Viral Production ◽  
Acid Receptor ◽  
Infection Mode ◽  
Sialic Acid Receptor

HA binds with the sialic acid receptor on the host cell and initiates the infection mode of influenza virus. NA cleaves the connection between receptor and HA of newborn virus at the end of viral production.

Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX

2014 ◽  
Vol 50 (63) ◽  
pp. 8719-8722 ◽  
Author(s):  
Yeh-Hsing Lao ◽  
Hui-Yu Chiang ◽  
Deng-Kai Yang ◽  
Konan Peck ◽  
Lin-Chi Chen
Keyword(s):  
Sialic Acid ◽  
Hemagglutination Inhibition ◽  
Acid Receptor ◽  
Effective Selection ◽  
Selection Of ◽  
Sialic Acid Receptor

Epitope-specific SELEX is reported for effective selection of aptamers against a native protein's functional epitope. Anti-sialic acid receptor aptamers are selected. Hemagglutination inhibition and structural evidence are provided to prove the aptamers.

Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

1998 ◽  
Vol 39 (20) ◽  
pp. 3111-3114 ◽  
Author(s):  
Steven Patterson ◽  
Bradley D. Smith ◽  
Richard E. Taylor
Keyword(s):  
Sialic Acid ◽  
Combinatorial Chemistry ◽  
Acid Receptor ◽  
Sialic Acid Receptor

Discovery of Siglec‐14, a novel sialic acid receptor undergoing concerted evolution with Siglec‐5 in primates

2006 ◽  
Vol 20 (12) ◽  
pp. 1964-1973 ◽  
Author(s):  
Takashi Angata ◽  
Toshiyuki Hayakawa ◽  
Masahiro Yamanaka ◽  
Ajit Varki ◽  
Mitsuru Nakamura
Keyword(s):  
Sialic Acid ◽  
Concerted Evolution ◽  
Acid Receptor ◽  
Sialic Acid Receptor

Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin

2003 ◽  
Vol 70 (3) ◽  
pp. 391-398 ◽  
Author(s):  
I. Stephenson ◽  
J.M. Wood ◽  
K.G. Nicholson ◽  
M.C. Zambon
Keyword(s):  
Sialic Acid ◽  
Avian Influenza ◽  
Receptor Specificity ◽  
Acid Receptor ◽  
Sialic Acid Receptor

scholarly journals A Novel Series of Sialic Acid-Based Influenza Virus Inhibitors that Target Influenza Virus Neuraminidase

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 8
Author(s):  
von Itzstein
Keyword(s):  
Influenza Virus ◽  
Sialic Acid ◽  
Host Cell ◽  
Infected Host ◽  
Virus Spread ◽  
Human Pathogen ◽  
Infected Host Cell ◽  
Clinically Significant ◽  
Influenza Virus Neuraminidase

Influenza virus continues to be a clinically-significant human pathogen that causes bothepidemics and pandemics. Successful inhibition of the viral neuraminidase hinders the release ofvirion progeny from the infected host cell and significantly reduces further virus spread [...]

Sialic acid profiles in the respiratory tracts of selected species of raptors: evidence for potential binding sites for human and avian influenza A viruses

2011 ◽  
Vol 38 (8) ◽  
pp. 647
Author(s):  
Chun-Hua Han ◽  
Jian Lin ◽  
Xiuqing Wang ◽  
Jing-Wen Han ◽  
Hui-Juan Duan ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Epithelial Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Human Influenza ◽  
Influenza A Viruses ◽  
Bubo Bubo ◽  
Acid Receptor ◽  
Influenza A Virus Infection ◽  
Sialic Acid Receptor

Context The ability of influenza A viruses to recognise and bind to cell surface receptors such as sialic acid linked to galactose by an α2,3 linkage (SAα2,3-gal) and sialic acid linked to galactose by an α2,6 linkage (SAα2,6-gal) is a major determinant of influenza A virus infection. Although the epidemiological surveys of influenza A virus infection in raptors suggest that some raptor species are susceptible to influenza A viruses under natural conditions, the sialic acid profiles in the respiratory and intestinal tracts of raptors are unknown. Aims To examine the sialic acid receptor profiles in the respiratory tracts of the selected raptor species and assess the potential susceptibility of raptors to avian and human influenza viruses and the role of raptors in the epidemiology and evolution of influenza A viruses. Methods The lectin immunohistochemistry staining method was used to examine the sialic acid profiles in the respiratory tracts of eight different species of raptors. Key results A strong staining with Maackia amurensis agglutinin (MAA), specific for sialic acid linked to galactose by an α2,3 linkage (SAα2,3-gal), was observed in the epithelial cells of the respiratory tract of Accipiter nisus and Falco tinnunculus. However, a positive staining for both MAA and Sambucus nigra agglutinin (SNA), specific for sialic acid linked to galactose by an α2,6 linkage (SAα2,6-gal), was detected in the epithelial cells of the upper respiratory tract of Accipiter gularis, Buteo buteo, Otus sunia, Bubo bubo and Asio otus, and in the epithelial cells of the alveoli of Buteo buteo, Falco peregrinus, Otus sunia and Bubo bubo. Conclusions Both avian and human influenza A virus receptors are expressed in six species of raptors examined. There are some variations in the type and distribution of sialic acid receptor expression among different raptor species. No correlation between phylogeny of birds and their sialic acid receptor distributions was observed. Implications Since SAα2,3-gal and SAα2,6-gal are often considered as the primary receptors for avian influenza A viruses and human influenza A viruses, respectively, our data suggest that raptors could be a potential host for avian and human influenza A viruses.

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