Mesoporous silica nanoparticles as a carrier platform for intracellular delivery of nucleic acids

2017 ◽  
Vol 82 (6) ◽  
pp. 655-662 ◽  
Author(s):  
N. A. Keasberry ◽  
C. W. Yapp ◽  
A. Idris
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Intracellular Delivery

scholarly journals Mesoporous Silica Nanoparticles Based Antigens and Nucleic Acids Delivery: A Review

1970 ◽  
Vol 8 (2) ◽  
pp. 50-57
Author(s):  
Jemal Dilebo
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Mesoporous Structure ◽  
Nucleic Acid Delivery ◽  
Hollow Core ◽  
Small Molecule Drugs ◽  
Cell Accumulation ◽  
Nucleic Acids Delivery

Mesoporous silica nanoparticles (MSN) have been explored for the delivery of small molecule drugs, antigens, and nucleic acids because of their large surface area, pore volume, amenability of their surface for functionalization, stable mesoporous structure, and biocompatibility.  Biomoecules loading capacitites,  release and target cell accumulation efficiencies have been improved for both antigen and nucleic acid delivery by the synthesis of large-pore MSN, dendritic MSN, hollow-core MSN, and multifunctional MSN. This article overview the major advances in the use of MSN for delivery of antigens and therapeutic nucleic acids such as DNA, siRNA, and miRNA aimed for treatment of various diseases.       

scholarly journals Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 432 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Action ◽  
The Creation

The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

Hypersound-Enhanced Intracellular Delivery of Drug-Loaded Mesoporous Silica Nanoparticles in a Non-Endosomal Pathway

2019 ◽  
Vol 11 (22) ◽  
pp. 19734-19742 ◽  
Author(s):  
Yao Lu ◽  
Loganathan Palanikumar ◽  
Eun Seong Choi ◽  
Jurriaan Huskens ◽  
Ja-Hyoung Ryu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Intracellular Delivery ◽  
Endosomal Pathway
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