Sex-dependent differences in parameters of long-term pain caused by inflammatory focus in prenatally stressed newborn rats

2007 ◽  
Vol 43 (1) ◽  
pp. 61-68
Author(s):  
I. P. Butkevich ◽  
G. A. Barr ◽  
E. A. Vershinina
Keyword(s):  
Newborn Rats ◽  
Inflammatory Focus ◽  
Prenatally Stressed

Neuroprotective Effect of Long-term MgSO4 Administration After Cerebral Hypoxia-Ischemia in Newborn Rats Is Related to the Severity of Brain Damage

2007 ◽  
Vol 14 (7) ◽  
pp. 667-677 ◽  
Author(s):  
Evangelia Spandou ◽  
Vassiliki Soubasi ◽  
Stamatia Papoutsopoulou ◽  
Persefoni Augoustides-Savvopoulou ◽  
Theodoros Loizidis ◽  
...  
Keyword(s):  
Brain Damage ◽  
Neuroprotective Effect ◽  
Cerebral Hypoxia ◽  
Newborn Rats ◽  
Hypoxia Ischemia

scholarly journals Compensatory rebound of body movements during sleep, after asphyxia in neonatal rats

2008 ◽  
Vol 23 (3) ◽  
pp. 253-257
Author(s):  
Olivia Adayr Xavier Suarez ◽  
Katsumasa Hoshino
Keyword(s):  
Perinatal Asphyxia ◽  
Recovery Period ◽  
Control Period ◽  
Neonatal Rats ◽  
Newborn Rats ◽  
Body Movements ◽  
Movement Frequency ◽  
Sleep Parameters ◽  
Long Term Consequences

PURPOSE: The usefulness of body movements that occur during sleep when assessing perinatal asphyxia and predicting its long-term consequences is contradictory. This study investigated whether neonatal rats manifest these movements in compensatory rebound after asphyxia, and if these alterations play an important role in its pathogenesis. METHODS: Eight neonatal rats (aged 6-48h) were implanted with small EMG and EKG electrodes and sleep movements were recorded over a 30-minute control period. Recordings were continued during asphyxia caused by the enclosure of the animal in a polyvinyl sheet for 60 minutes, followed by a 30-minute recovery period. RESULTS: Heart rate was lowered to bradycardic level during asphyxia causing behavioral agitation and increased waking time during the initial phase (30 minutes). Sleep-related movements were also significantly reduced from 12.5 ± 0.5 (median ± SE/2min) to 9.0 ± 0.44 in the final half of the period (Anova, p<0.05). Movement frequency increased in the recovery period to 15.0 ± 0.49 (Anova, p<0.05). CONCLUSION: These data show that newborn rats present compensatory rebound of body movements during sleep which may help in the diagnosis of asphyxia and other problems related to sleep parameters.

Long term effects of high fat diet given early in life in prenatally stressed rats: role of the inflammatory response

2019 ◽  
Vol 29 ◽  
pp. S225-S226
Author(s):  
M. Mazzelli ◽  
N. Cattane ◽  
C. Mora ◽  
V. Begni ◽  
A. Berry ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
High Fat Diet ◽  
Long Term Effects ◽  
High Fat ◽  
Prenatally Stressed

Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure

2002 ◽  
Vol 283 (3) ◽  
pp. L555-L562 ◽  
Author(s):  
Timothy D. Le Cras ◽  
Neil E. Markham ◽  
Rubin M. Tuder ◽  
Norbert F. Voelkel ◽  
Steven H. Abman
Keyword(s):  
Pulmonary Hypertension ◽  
Vegf Receptor ◽  
Newborn Rats ◽  
Long Term Effects ◽  
Adult Rats ◽  
Rat Pups ◽  
Lung Structure ◽  
Vegfr Inhibitor ◽  
And Function

To determine whether disruption of vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling in the newborn has long-term effects on lung structure and function, we injected 1-day-old newborn rat pups with a single dose of Su-5416, a VEGFR inhibitor, or vehicle (controls). Lungs from infant (3-wk-old) and adult (3- to 4-mo-old) rats treated with Su-5416 as newborns showed reductions in arterial density (82 and 31%, respectively) and alveolar counts (45 and 29%) compared with controls. Neonatal treatment with Su-5416 increased right ventricle weight to body wt ratios (4.2-fold and 2.0-fold) and pulmonary arterial wall thickness measurements (2.7-fold and 1.6-fold) in infant and adult rats, respectively, indicating marked pulmonary hypertension. We conclude that treatment of newborn rats with the VEGFR inhibitor Su-5416 impaired pulmonary vascular growth and postnatal alveolarization and caused pulmonary hypertension and that these effects were long term, persisting well into adulthood.

scholarly journals Early and long-term neuroendocrine effects of prenatal stress in male and female rats

2000 ◽  
Vol 46 (1) ◽  
pp. 30-34 ◽  
Author(s):  
A. G. Reznikov ◽  
N. D. Nosenko ◽  
L. V. Tarasenko ◽  
P. V. Sinitsyn ◽  
L. I. Polyakova
Keyword(s):  
Prenatal Stress ◽  
Stress Reactivity ◽  
Female Rats ◽  
Male And Female Rats ◽  
Prenatally Stressed ◽  
Old Rats ◽  
Males And Females ◽  
Morphological Equivalent ◽  
The Brain

The effect of maternal stress or so-called prenatal stress (PS) on the neuroendocrine regulation of reproduction and stress reactivity of the progeny was studied. Prenatal stress prevented the formation of sex dimorphism of catecholamine content and aromatase and androgen 5a-reductase activities in the preoptic region of the brain and mediobasal hypothalamus of 10-day-old rats. Leveling of sex-specific differences in the size of the neurocyte nuclei in the suprachiasmatic nucleus was the morphological equivalent of functional disorders induced by PS. Stress and adrenergic reactivity of the hypothalamo-pituitary-adrenal system was changed in prenatally stressed males and females. Remote effects of PS are regarded as a manifestation of disorders in the hormone neurotransmitter imprinting of the neuroendocrine system.

scholarly journals Identification of newborn rats by tattooing

1989 ◽  
Vol 23 (4) ◽  
pp. 361-364 ◽  
Author(s):  
S. Iwaki ◽  
A. Matsuo ◽  
A. Kast
Keyword(s):  
The Other ◽  
View Point ◽  
Newborn Rats ◽  
Plantar Surface ◽  
Identification Method ◽  
Reproductive Capability ◽  
Behavioural Tests ◽  
Term Identification ◽  
Suspension Test

Pups were identified by toe clipping or tattooing the plantar surface of the paws on day 4 after delivery. Their growth, maturation, and reproductive capability were not affected by either identification method. In the toe clipping group, however, the duration until fall in the suspension test was significantly shortened, indicating that this identification method may not be suitable for some behavioural tests. The clipping also disturbs the skeletal investigation of toes and is not recommended from the view point of animal welfare. Palm tattooing, on the other hand, satisfies the fundamental requirements for long-term identification of rats.

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