Gene dunce Localization in the Polytene Chromosome of Drosophila melanogaster Long Span Batch of Adjacent Chromosomal Structures

2019 ◽  
Vol 484 (1) ◽  
pp. 55-58 ◽  
Author(s):  
V. A. Khoroshko ◽  
G. V. Pokholkova ◽  
T. Yu. Zykova ◽  
I. S. Osadchiy ◽  
I. F. Zhimulev
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Long Span

scholarly journals Gene dunce localization in the polytene chromosome of Drosophila melanogaster long span batch of adjacent chromosomal structures

2019 ◽  
Vol 484 (4) ◽  
pp. 507-510
Author(s):  
V. A. Khoroshko ◽  
G. V. Pokholkova ◽  
T. Yu. Zykova ◽  
I. S. Osadchiy ◽  
I. F. Zhimulev
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Chromosomal Localization ◽  
Current Understanding ◽  
Fish Analysis ◽  
Tissue Specific ◽  
Genetic Organization ◽  
Long Span ◽  
The Common

The molecular and chromosomal localization of the dunce gene was studied. This gene (167.3 kb) consists almost entirely of introns, in which a cluster of seven short tissue-specific genes is located. On the basis of the results of FISH analysis of the gene fragments, we established that the dunce gene is located within nine chromosomal structures (four bands and five interbands), which contradicts the common idea that genes are located in only one structure (band or interband) or at the boundary of these structures. Our results are quite unexpected and original and greatly expand the current understanding of the genetic organization of interphase chromosomes.

scholarly journals CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

Genetics ◽  
1980 ◽  
Vol 94 (1) ◽  
pp. 115-133 ◽  
Author(s):  
Thomas C Kaufman ◽  
Ricki Lewis ◽  
Barbara Wakimoto
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Cytogenetic Analysis ◽  
Proximal Portion ◽  
Chromosome 3 ◽  
Gene Complex ◽  
Anterior Portion ◽  
Cytogenetic Evidence ◽  
The Right

ABSTRACT Cytogenetic evidence is presented demonstrating that the 84A-B interval in the proximal portion of the right arm of chromosome 3 is the residence of a homoeotic gene complex similar to the bithorax locus. This complex, originally defined by the Antennapedia (A n t p) mutation, controls segmentation in the anterior portion of the organism. Different lesions within this complex homoeotically transform portions OI the prothorax, proboscis, antenna and eye and present clear analogies to similar lesions within the bithorax locus.

scholarly journals CYTOGENETIC ANALYSIS OF THE CHROMOSOMAL REGION IMMEDIATELY ADJACENT TO THE ROSY LOCUS IN DROSOPHILA MELANOGASTER

Genetics ◽  
1980 ◽  
Vol 95 (1) ◽  
pp. 95-110 ◽  
Author(s):  
Arthur J Hilliker ◽  
Stephen H Clark ◽  
Arthur Chovnick ◽  
William M Gelbart
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Structural Information ◽  
Genetic Regulation ◽  
Chromosome Band ◽  
Genetic Dissection ◽  
Genetic Unit ◽  
Complementation Groups ◽  
The Relationship ◽  
Chromosome Bands

ABSTRACT This report describes the genetic analysis of a region of the third chromosome of Drosophila melanogaster extending from 87D2-4 to 87E12-F1, an interval of 23 or 24 polytene chromosome bands. This region includes the rosy (ry, 3-52.0) locus, carrying the structural information for xanthine dehydrogenase (XDH). We have, in recent years, focused attention on the genetic regulation of the rosy locus and, therefore, wished to ascertain in detail the immediate genetic environmcnt of this locus. Specifically, we question if rosy is a solitary genetic unit or part of a larger complex genetic unit encompassing adjacent genes. Our data also provide opportunity to examine further the relationship between euchromatic gene distrihution and polytene chromosome structure.—The results of our genetic dissection of the rosy microregion substantiate the conclusion drawn earlier (SCHALET, KERNAGHAN and CHOVNICK 1964) that the rosy locus is the only gene in this region concerned with XDH activity and that all adjacent genetic units are functionally, as well as spatially, distinct Erom the rosy gene. Within the rosy micro-region, we observed a close correspondence between the number of complementation groups (21) and the number of polytene chromosome bands (23 or 24). Consideration of this latter observation in conjunction with those of similar studies of other chhromosomal regions supports the hypothesis that each polytene chromosome band corresponds to a single genetic unit.

A CYTOGENETIC ANALYSIS OF THE CHROMOSOMAL REGION SURROUNDING THE α-GLYCEROPHOSPHATE DEHYDROGENASE LOCUS OF DROSOPHILA MELANOGASTER

Genetics ◽  
1983 ◽  
Vol 105 (2) ◽  
pp. 371-386
Author(s):  
Michael A Kotarski ◽  
Sally Pickert ◽  
Ross J MacIntyre
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Cytogenetic Analysis ◽  
Chromosomal Region ◽  
Chromosome Band ◽  
Recombination Analysis ◽  
Chromosome 2 ◽  
Recessive Lethal ◽  
Lethal Mutations ◽  
Glycerophosphate Dehydrogenase

ABSTRACT The chromosomal region surrounding the structural gene for α-glycerophosphate dehydrogenase (αGpdh, 2-20.5) of Drosophila melanogaster has been studied in detail. Forty-three EMS-induced recessive lethal mutations and five previously identified visible mutations have been localized within the 25A-27D region of chromosome 2 by deficiency mapping and in some cases by a recombination analysis. The 43 lethal mutations specify 17 lethal loci. ?Gpdh has been localized to a single polytene chromosome band, 25F5, and there apparently are no lethals that map to the αGpdh locus.

scholarly journals MUTATIONAL EVENTS IN THE TRIPLO- AND HAPLO-LETHAL REGION (83DE) OF THE DROSOPHILA MELANOGASTER GENOME

Genetics ◽  
1980 ◽  
Vol 95 (2) ◽  
pp. 355-366
Author(s):  
Richard L Roehrdanz ◽  
John C Lucchesi
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Structural Organization ◽  
Sensitive Information ◽  
Induced Mutations ◽  
Chromosome Map ◽  
Single Region ◽  
Heterozygous Deficiency

ABSTRACT The Drosophila melanogaster genome contains a single region (at 83DE on the polytene chromosome map) for which both heterozygous deficiency and heterozygous duplication are inviable. Seven EMS-induced mutations have been recovered that are viable in combination with a duplication of this region. Two classes of mutations are reported: (1) Mutations that allow survival of flies with either a duplication or a normal third chromosome. These mutations retain Ki, a closely linked marker on the mutagenized chromosome. They fail to complement, and one has been mapped to the vicinity of 83DE. (2) Mutations that allow survival only in heterozygous combination with a duplication and have lost the Ki marker. These mutations represent new deletions of the dose-sensitive information. The possible structural organization of the 83DE region is discussed in light of these two classes of mutations.

Alpha and beta heterochromatin in polytene chromosome 2 of Drosophila melanogaster

Chromosoma ◽  
1996 ◽  
Vol 105 (5) ◽  
pp. 310-319
Author(s):  
Dmitry E. Koryakov ◽  
Elena S. Belyaeva ◽  
Artyom A. Alekseyenko ◽  
Igor F. Zhimulev
Keyword(s):  
Drosophila Melanogaster ◽  
Polytene Chromosome ◽  
Chromosome 2

scholarly journals Genetic localization of foraging (for): a major gene for larval behavior in Drosophila melanogaster.

Genetics ◽  
1989 ◽  
Vol 123 (1) ◽  
pp. 157-163 ◽  
Author(s):  
J S de Belle ◽  
A J Hilliker ◽  
M B Sokolowski
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Markers ◽  
Polytene Chromosome ◽  
Quantitative Traits ◽  
Major Gene ◽  
Larval Behavior ◽  
Chromosome Map ◽  
Naturally Occurring ◽  
Formidable Challenge ◽  
Recombination Mapping

Abstract Localizing genes for quantitative traits by conventional recombination mapping is a formidable challenge because environmental variation, minor genes, and genetic markers have modifying effects on continuously varying phenotypes. We describe "lethal tagging," a method used in conjunction with deficiency mapping for localizing major genes associated with quantitative traits. Rover/sitter is a naturally occurring larval foraging polymorphism in Drosophila melanogaster which has a polygenic pattern of inheritance comprised of a single major gene (foraging) and minor modifier genes. We have successfully localized the lethal tagged foraging (for, 2-10) gene by deficiency mapping to 24A3-C5 on the polytene chromosome map.

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