Ab initio SCF study of the effect of Na+ and K+ ions and water on the local anaesthetic-phospholipid interaction
1989 ◽
Vol 54
(4)
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pp. 862-867
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Keyword(s):
For gaining insight into the interactions of local anaesthetics with phospholipids, ab initio molecular orbital calculations were performed using trimethylamine and phosphate as model substances. The (OH)2OPO-···H+N(CH3)3 interaction was found comparable in strength to the (OH)2OPO-···M+ (M = Na, K) interaction and considerably stronger than the (OH)2OMPO···H2O interaction. This suggests that a major role of local anaesthetics may consist in their disturbing the P-O···H2O hydrogen bonds. Such interference may be one of the possible types of interaction between local anaesthetics and the biophase, leading to a measurable pharmacological effect.
1979 ◽
Vol 101
(8)
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pp. 1997-2002
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2001 ◽
Vol 57
(6)
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pp. 850-858
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1998 ◽
Vol 54
(3)
◽
pp. 320-329
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1997 ◽
Vol 53
(6)
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pp. 1017-1024
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Keyword(s):
1975 ◽
Vol 343
(1632)
◽
pp. 1-10
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1975 ◽
Vol 30
(1)
◽
pp. 58-59
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Keyword(s):
1981 ◽
Vol 36
(11)
◽
pp. 1246-1252
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1997 ◽
Vol 393
(1-3)
◽
pp. 121-126
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