The significance of transmembrane segment of EGF-receptor in transduction of hormone signal

1999 ◽  
Author(s):  
Mária Ficková ◽  
Štefan Zorad ◽  
Gerard Cremel
Keyword(s):  
Egf Receptor ◽  
Transmembrane Segment

947: Chemopreventive Effects of COX-2 Inhibitor and Epidermal Growth Factor (EGF)-Receptor Kinase Inhibitor on Rat Urinary Bladder Tumorigenesis

2004 ◽  
Vol 171 (4S) ◽  
pp. 251-251
Author(s):  
Kazunori Hattori ◽  
Katsuyuki Iida ◽  
Akira Johraku ◽  
Sadamu Tsukamoto ◽  
Taeko Asano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Urinary Bladder ◽  
Egf Receptor ◽  
Kinase Inhibitor ◽  
Receptor Kinase ◽  
Rat Urinary Bladder ◽  
Epidermal Growth ◽  
Cox 2

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

2009 ◽  
Vol 138 (3) ◽  
pp. 604-604
Author(s):  
Natalia Jura ◽  
Nicholas F. Endres ◽  
Kate Engel ◽  
Sebastian Deindl ◽  
Rahul Das ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Catalytic Domain

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

2009 ◽  
Vol 138 (33) ◽  
pp. 604-604
Author(s):  
Natalia Jura ◽  
Nicholas F. Endres ◽  
Kate Engel ◽  
Sebastian Deindl ◽  
Rahul Das ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Catalytic Domain

Quantum Calculation of Proton and Other Charge Transfer Steps in Voltage Sensing in the Kv1.2 Channel

2019 ◽  
Author(s):  
Alisher M Kariev ◽  
Michael Green
Keyword(s):  
Charge Transfer ◽  
Energy Charge ◽  
Quantum Calculation ◽  
Quantum Calculations ◽  
Gating Current ◽  
Transmembrane Segment ◽  
Voltage Sensing ◽  
Standard Models ◽  
Charge Displacement ◽  
Voltage Sensing Domain

Quantum calculations on 976 atoms of the voltage sensing domain of the K<sub>v</sub>1.2 channel, with protons in several positions, give energy, charge transfer, and other properties. Motion of the S4 transmembrane segment that accounts for gating current in standard models is shown not to occur; there is H<sup>+ </sup>transfer instead. The potential at which two proton positions cross in energy approximately corresponds to the gating potential for the channel. The charge displacement seems approximately correct for the gating current. Two mutations are accounted for (Y266F, R300cit, cit =citrulline). The primary conclusion is that voltage sensing depends on H<sup>+</sup> transfer, not motion of arginine charges.

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