EGF Receptor in Tumor Growth and Progression

1997 ◽  
Keyword(s):  
Tumor Growth ◽  
Egf Receptor

scholarly journals Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Oncotarget ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 5164-5181 ◽  
Author(s):  
Parthasarathy Seshacharyulu ◽  
Moorthy P. Ponnusamy ◽  
Satyanarayana Rachagani ◽  
Imayavaramban Lakshmanan ◽  
Dhanya Haridas ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Growth ◽  
Egf Receptor ◽  
Human Pancreatic Cancer ◽  
Tumor Growth And Metastasis

Heterogeneity in Epidermal Growth Factor Responsiveness and Tumor Growth of Human Maxillary Cancer Cell Lines

1992 ◽  
Vol 101 (6) ◽  
pp. 519-524 ◽  
Author(s):  
Sohtaro Komiyama ◽  
Shohji Kudoh ◽  
Katsuko Matsui ◽  
Hiromoto Mizoguchi ◽  
Hiroshi Miyazaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tumor Growth ◽  
Cell Lines ◽  
Nude Mice ◽  
Egf Receptor ◽  
Slow Growth ◽  
Maxillary Cancer ◽  
Epidermal Growth ◽  
Intermediate Rate

We have established three cell lines (IMC-2, IMC-3, and IMC-4) from a human maxillary tumor, which exhibited different sensitivities to epidermal growth factor (ECF). It was inhibitory to colony-forming abilities of IMC-3 and IMC-4 cells in culture, while it affected that of IMC-2 cells slightly if at all. The differential sensitivities to EGF among the three cell lines were reproducibly observed when several cell sublines were further established from tumors appearing in nude mice. Saturation-binding kinetics with 125I-EGF showed similar levels of EGF-binding activities among the three cell lines. However, IMC-2, IMC-3, and IMC-4 showed almost similar sensitivities to cisplatin. Autophosphorylation of EGF receptor in the presence of EGF proceeded at similar levels among the three cell lines. Tumor growth was followed in nude mice when IMC-2, IMC-3, and IMC-4 at 1 × 107 cells were inoculated. The IMC-2 tumors enlarged at much faster rates than the other two cell lines. The IMC-4 tumors showed very slow growth rates, and IMC-3 tumors enlarged at an intermediate rate. These data suggest that the maxillary tumor used comprised cell populations that differed in their growth behaviors in response to EGF.

scholarly journals EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells

2009 ◽  
Vol 390 (12) ◽  
Author(s):  
Peter Camaj ◽  
Hendrik Seeliger ◽  
Ivan Ischenko ◽  
Stefan Krebs ◽  
Helmut Blum ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Tumor Growth ◽  
Pancreatic Carcinoma ◽  
Matrix Protein ◽  
Egf Receptor ◽  
Kinase Inhibitor ◽  
Carcinoma Cells ◽  
Mitogen Activated Protein Kinase ◽  
Extracellular Matrix Protein ◽  
Mitogen Activated Protein

Abstract The EGF-related protein EFEMP1 (EGF-containing fibulin-like extracellular matrix protein 1) has been shown to promote tumor growth in human adenocarcinoma. To understand the mechanism of this action, the signal transduction activated upon treatment with this protein has been investigated. We show that EFEMP1 binds EGF receptor (EGFR) in a competitive manner relative to epidermal growth factor (EGF), implicating that EFEMP1 and EGF share the same or adjacent binding sites on the EGFR. Treatment of pancreatic carcinoma cells with purified EFEMP1 activates autophosphorylation of EGFR at the positions Tyr-992 and Tyr-1068, but not at the position Tyr-1048. This signal is further transduced to phosphorylation of Akt at position Thr-308 and p44/p42 MAPK (mitogen-activated protein kinase) at positions Thr-202 and Tyr-204. These downstream phosphorylation events can be inhibited by treatment with the EGFR kinase inhibitor PD 153035. The observed signal transduction upon treatment with EFEMP1 can contribute to the enhancement of tumor growth shown in pancreatic carcinoma cells overexpressing EFEMP1.

scholarly journals Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apcmin Mice

2009 ◽  
Vol 137 (3) ◽  
pp. 914-923 ◽  
Author(s):  
Xinhua Chen ◽  
Johannes Fruehauf ◽  
Jeffrey D. Goldsmith ◽  
Hua Xu ◽  
Kianoosh K. Katchar ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Egf Receptor ◽  
Saccharomyces Boulardii ◽  
Intestinal Tumor ◽  
Receptor Signaling

Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier

2010 ◽  
Vol 28 (4) ◽  
pp. 731-741 ◽  
Author(s):  
David Schaffert ◽  
Melinda Kiss ◽  
Wolfgang Rödl ◽  
Alexei Shir ◽  
Alexander Levitzki ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Tumor Growth ◽  
Egf Receptor ◽  
Growth Suppression ◽  
Poly I:C ◽  
Linear Polyethylenimine ◽  
Tumor Growth Suppression

scholarly journals The effects of EGF-receptor density on multiscale tumor growth patterns

2006 ◽  
Vol 238 (4) ◽  
pp. 771-779 ◽  
Author(s):  
Chaitanya A. Athale ◽  
Thomas S. Deisboeck
Keyword(s):  
Tumor Growth ◽  
Egf Receptor ◽  
Growth Patterns ◽  
Receptor Density

scholarly journals Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA

Nanomedicine ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. 475-491 ◽  
Author(s):  
B Leticia Rodriguez ◽  
Xinran Li ◽  
Kaoru Kiguchi ◽  
John DiGiovanni ◽  
Evan C Unger ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Solid Tumor ◽  
Plasmid Dna ◽  
Egf Receptor ◽  
Solid Tumor Growth

655: EBAG9/RCAS1 Expression Enhances Tumor Growth in Renal Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 178-179
Author(s):  
Tetsuo Ogushi ◽  
Takahashi Satoru ◽  
Takumi Takeuchi ◽  
Tetsuya Fujimura ◽  
Tomohiko Urano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell
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