112 Background: The number of prescribed medications increases substantially in the last year of life aggravating the risk of polypharmacy, adverse reactions and medication non-adherence. What medications do patients with life-limiting illness take? Methods: This was a pre-specified secondary analysis of data from a prospective trial. Eligible participants were adults with a <1-year prognosis taking a statin medication for primary or secondary prevention. Participants were enrolled from 15 sites, randomized to continue or discontinue statin medications, and followed for up to a year. Concomitant medications were recorded at least monthly. For participants with a primary diagnosis of cancer receiving care and with medication data available, prescribed medications were categorized according to the World Health Organization’s (WHO) ‘Guidelines for ATC Classification’ by class and sub-class. An expert panel of palliative care, oncology, geriatrics, and primary care physicians guided categorization. Descriptive statistics were calculated. Results: On average, participants (N=127) were 70 years old (SD 10) and lived 216 days (SD 123) on study; 69% had metastases, 23% had cancer without metastases, 7% had lymphoma, and 1 had leukemia. In total, 49 classes, 156 sub-classes and 283 different medications were prescribed. The five most commonly prescribed medications were: anti-hypertensives, strong opioids, laxatives, gastric protection aids, and anti-emetics. Only 1.2% of medications prescribed were chemotherapy or antineoplastics. Patients took an average of 10.7 (SD 5) number of medications at the time of enrollment and 10.0 (SD 5) medications at death or termination of the study. 31% of patients were on 15 or more medications at any time during the study. Conclusions: Polypharmacy, defined as >10 medicines, is common in the last year of life for people with cancer. Patients commonly receive supportive care medications and drugs for comorbidities like hypertension; antineoplastics are rare. Thoughtful approaches to medication simplification in the palliative care setting are needed.