THU0303 The efficacy and safety of ibandronic acid for intravenous administration for treatment of severe systemic osteoporosis in patients with juvenile arthritis

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 258.2-258
Author(s):  
S. Valiyeva ◽  
E. Alexeeva ◽  
T. Bzarova ◽  
R. Denisova ◽  
K. Isayeva ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Juvenile Arthritis ◽  
Efficacy And Safety ◽  
Ibandronic Acid

The Efficacy and Safety of Continuous Intravenous Administration of Remifentanil for Birth Pain Relief: An Open Study of 205 Parturients

2009 ◽  
Vol 109 (6) ◽  
pp. 1922-1924 ◽  
Author(s):  
Paola D’Onofrio ◽  
Anna Maria Melani Novelli ◽  
Federico Mecacci ◽  
Gianfranco Scarselli
Keyword(s):  
Pain Relief ◽  
Intravenous Administration ◽  
Open Study ◽  
Efficacy And Safety

scholarly journals Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases

2021 ◽  
Vol 147 (10) ◽  
pp. 3025-3042
Author(s):  
Catalina Hoppe ◽  
Maren Freuding ◽  
Jens Büntzel ◽  
Karsten Münstedt ◽  
Jutta Hübner
Keyword(s):  
Vitamin C ◽  
Intravenous Administration ◽  
Complementary Therapy ◽  
The Body ◽  
Water Soluble ◽  
Radical Scavenger ◽  
Positive Trend ◽  
Malignant Diseases ◽  
Efficacy And Safety ◽  
Group Comparisons

Abstract Background Vitamin C, also called ascorbic acid, is a water-soluble antioxidant and free radical scavenger. It is required in the body for numerous metabolic functions and is involved in the development of proteins and connective tissue. Methods In April 2020, a systematic search was carried out on five electronic databases (Medline, Embase, Cochrane, Cinahl, PsycINFO) to find studies on the use, efficacy and safety of a complementary therapy with vitamin C in oncological patients. Results Out of the initial 23,195 search results, 21 studies with 1961 patients were included in this review. Five of the included studies (n = 417) were randomized controlled trials (RCTs). The remaining 16 studies belonged to a lower class of evidence. The patients who were treated with vitamin C suffered from various malignant diseases, some in an advanced and palliative stage. Vitamin C was applied intravenously or orally. It was either the only treatment or was combined with chemo- or radiotherapy. Endpoints included the development of the disease-related symptoms, quality of life, mortality, progression-free survival and safety of vitamin C. The studies were of moderate quality and showed either no effect of vitamin C or a positive trend, although this has rarely been statistically proven in group comparisons. No or only slight side effects with both oral and intravenous administration of vitamin C were reported. Conclusion Oral intake of vitamin C does not appear to have any effect in patients with malignancies. Data are heterogeneous for intravenous administration. There are no RCTs with statistical group comparisons.

scholarly journals Topical versus intravenous administration of tranexamic acid in primary total hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials

2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Sammy A. Hanna ◽  
Anoop Prasad ◽  
Joshua Lee ◽  
Pramod Achan
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Randomized Controlled Trials ◽  
Intravenous Administration ◽  
Hip Arthroplasty ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled

Tranexamic acid (TA) is widely used by orthopedic surgeons to decrease blood loss and the need for transfusion following total hip arthroplasty (THA). Although both intravenous and topical applications are described in the literature, there remains no consensus regarding the optimal regimen, dosage and method of delivery of TA during THA. In addition, concerns still exist regarding the risk of thromboembolic events with intravenous administration. The purpose of this meta-analysis was to compare the efficacy and safety of topical <em>versus</em> intravenous administration of TA in THA. A systemic review of the electronic databases PubMed, CENTRAL, EMBASE and Google Scholar was undertaken to identify all randomized controlled trials (RCTs) comparing the topical and intravenous administration of TA during THA, in terms of total blood loss, rate of blood transfusion and incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) post-operatively. A meta-analysis was performed to evaluate and compare the efficacy and safety of both methods of administration. Of 248 potentially relevant papers, three RCTs comprising (482) were eligible for data extraction and metaanalysis. The results showed a slightly higher amount of blood loss [Mean Difference (MD) – 46.37, P=0.12, 95% confidence interval (CI) – 12.54 to 105.29] and rate of transfusion (Risk Ratio 1.30, P=0.39, 95%CI 0.71 to 2.37) postoperatively in the topical TA group, but both did not reach statistical significance. There were 3 cases (1.2%) of DVT/PE in the intravenous group and one case (0.4%) in the topical group. Topical TA is an effective and safe method to reduce blood loss and the rate of transfusion following primary THA. It has comparative effectiveness to IV administration with slightly less post-operative thromboembolic complications. Larger and better-designed RCTs are required to establish the optimum dosage and regimen for topical use.

scholarly journals Crystalloid and Colloid Compositions and Their Impact

2021 ◽  
Vol 8 ◽  
Author(s):  
Elke Rudloff ◽  
Kate Hopper
Keyword(s):  
Critical Illness ◽  
Intravenous Administration ◽  
Plasma Composition ◽  
Efficacy And Safety ◽  
Acid Base ◽  
Organ Systems

This manuscript will review crystalloid (hypo-, iso-, and hyper-tonic) and colloid (synthetic and natural) fluids that are available for intravenous administration with a focus on their electrolyte, acid-base, colligative, and rheological effects as they relate to each solution's efficacy and safety. The goal is for the reader to better understand the differences between each fluid and the influence on plasma composition, key organ systems, and their implications when used therapeutically in animals with critical illness.

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