Elevated serum level of the vascular endothelial growth factor predicts radiographic spinal progression in patients with axial spondyloarthritis

Background The aim of the present study was to determine whether serum vascular endothelial growth factor (VEGF) can provide prognostic information independent of carcinoembryonic antigen levels in patients undergoing curative surgery. Methods Serum samples were collected from 158 patients with colorectal cancer and from 100 controls. Serum and tissue levels of VEGF were measured by enzyme-linked immunosorbent assay. Serum VEGF levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum VEGF levels and clinicopathologic findings and survival. Results VEGF expression was significantly higher in colorectal cancer tissue compared with nontumor tissue. Mean serum VEGF levels in patients were significantly higher than those in controls, and significantly higher in patients with large tumors, lymph node involvement, and distant metastases. Conclusion Elevated serum VEGF was significantly associated with poor survival, but was only an independent risk factor for poor survival in Stage II and/or III disease. Elevated serum VEGF is significantly associated with development of colorectal cancer, and lymph or distant invasive phenotypes and survival, especially in Stage II and III patients.

Download Full-text

Is serum level of vascular endothelial growth factor 165 related to fibroid volume in patients before and after hysterectomy?

Fertility and Sterility ◽

10.1016/s0015-0282(03)01640-6 ◽

2003 ◽

Vol 80 ◽

pp. 256

Author(s):

Da-Chung Chen ◽

Jah-Yao Liu ◽

Gwo-Jang Wu ◽

Chih-Hung Ku ◽

Chi-Huang Chen

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Serum Level ◽

Vascular Endothelial ◽

Before And After ◽

Endothelial Growth Factor ◽

Fibroid Volume

Download Full-text

VASCULAR ENDOTHELIAL GROWTH FACTOR IN CHILDREN WITH THALASSEMIA MAJOR PDF

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2013.044 ◽

2013 ◽

Vol 5 (1) ◽

pp. e2013044 ◽

Cited By ~ 7

Author(s):

Sameh Samir Fahmey ◽

Hassan Naguib ◽

Sanna Abdelshafy ◽

Rasha Alashry

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Blood Transfusion ◽

Elevated Serum ◽

Thalassemia Major ◽

Enzyme Linked Immunosorbent Assay ◽

Vascular Endothelial ◽

Healthy Controls ◽

Endothelial Growth Factor ◽

Vegf Level

Background: The β-Thalassemia syndromes are the most common hereditary chronic hemolytic anemia due to impaired globin chain synthesis. Vascular endothelial growth factor (VEGF) plays several roles in angiogenesis which is a crucial process in the pathogenesis of several inflammatory, autoimmune and malignant diseases .Endothelial damage and inflammation make a significant contribution to the pathophysiology of β-thalassemia. Purpose: The aim of the study was to assess serum VEGF level in children with beta-thalassemia major as a marker of angiogenesis. Methods: Blood samples were collected from 40 patients with thalassemia major and 10 healthy controls and assayed for VEGF by enzyme-linked immunosorbent assay. Results: VEGF level was significantly higher in patients with β-Thalassemia major than healthy controls (p=0.001).In addition, VEGF level was higher in splenectomised thalassemic patients than non splenectomised ones (p=0.001) .However, there were a positive correlation between VEGF and chelation starting age (p=0.008) and a negative correlation between VEGF and frequency of blood transfusion (p=0.002). Conclusion: thalassemia patients, especially splenectomized, have elevated serum levels of VEGF. Early chelation and regular blood transfusion help to decrease serum VEGF and the risk of angiogenesis.

Download Full-text