AB1031 Analysis of mechanism of transient increase in plasma urate levels induced by fructose in rats

Ineffective Thrombopoiesis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158881 ◽

1990 ◽

Vol 48 (3) ◽

pp. 266-267

Author(s):

JM Radley ◽

SL Ellis

Keyword(s):

Microscopic Examination ◽

Phosphate Buffer ◽

Primary Myelofibrosis ◽

Transient Increase ◽

Major Difficulty ◽

Adult Mice ◽

Dense Cytoplasm

In effective thrombopoies is has been inferred to occur in several disease sates from considerations of megakaryocyte mass and platelet kinetics. Microscopic examination has demonstrated increased numbers of megakaryocytes, with a typical forms particularly pronounced, in primary myelofibrosis. It has not been documented if megakaryocyte ever fail to reach maturity in non-pathological situations. A major difficulty of establishing this is that the number of megakaryocytes normally present in the marrow is extremely low. A large transient increase in megakaryocytopoiesis can how ever be induced in mice by an injection of 5-fluorouracil. We have utilised this treatment and report here evidence for in effective thrombopoies is in healthy mice.Adult mice were perfused (2% glutaraldehyde in 0.08M phosphate buffer, pH 7.4) 8 days following an injection of 5-fluorouracil (150mg/kg). Femurs were subsequently decalcified in 10% neutral E.D.T.A. and embedded in Spurrs resin. Transverse sections of marrow revealed many megakaryocytes at various stages of maturity. Occasional megakaryocytes (less than 1%) were found to be under going degeneration prior to achieving full maturation and releasing cytoplasm as platelets. These cells were characterized by a peripheral rim of dense cytoplasm which enveloped a mass of organelles and vacuoles (Fig. 1). Numerous microtubules were foundaround and with in the organelle-rich zone (Fig 2).

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A transient increase in the activity of CA3 neurons induces a long-lasting reduction in the excitability of schaffer collateral terminals in rat hippocampus

Neuroscience Letters ◽

10.1016/s0304-3940(85)80010-0 ◽

1985 ◽

Vol 54 (1-3) ◽

pp. 51-56 ◽

Cited By ~ 1

Author(s):

B SASTRY ◽

P MURALIMOHAN ◽

J GOH

Keyword(s):

Transient Increase ◽

Rat Hippocampus ◽

Schaffer Collateral ◽

Ca3 Neurons

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Faculty Opinions recommendation of Learning-dependent, transient increase of activity in noradrenergic neurons of locus coeruleus during slow wave sleep in the rat: brain stem-cortex interplay for memory consolidation?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1103341.559379 ◽

2008 ◽

Author(s):

Mark Mayford

Keyword(s):

Locus Coeruleus ◽

Brain Stem ◽

Rat Brain ◽

Slow Wave ◽

Memory Consolidation ◽

Slow Wave Sleep ◽

Transient Increase ◽

Noradrenergic Neurons

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Transient Increase in Herpes Simplex Virus Type 2 (HSV-2)–Associated Genital Ulcers Following Initiation of Antiretroviral Therapy in HIV/HSV-2–Coinfected Individuals

The Journal of Infectious Diseases ◽

10.1093/infdis/jiv765 ◽

2015 ◽

Vol 213 (10) ◽

pp. 1573-1578 ◽

Cited By ~ 5

Author(s):

Kenneth H. Fife ◽

Kenneth Mugwanya ◽

Katherine K. Thomas ◽

Jared M. Baeten ◽

Connie Celum ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Antiretroviral Therapy ◽

Virus Type ◽

Herpes Simplex Virus Type ◽

Transient Increase ◽

Genital Ulcers ◽

Simplex Virus

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Early life stress induces a transient increase in hippocampal corticotropin‐releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides

European Journal of Neuroscience ◽

10.1111/ejn.15193 ◽

2021 ◽

Author(s):

Angélica Roque ◽

Kinberli Marcela Valles Méndez ◽

Roberto Ruiz ◽

Edel Pineda ◽

Naima Lajud

Keyword(s):

Life Stress ◽

Early Life ◽

Early Life Stress ◽

Transient Increase ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Hypothalamic Neuropeptides

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Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)84884-6 ◽

1989 ◽

Vol 264 (26) ◽

pp. 15668-15673

Author(s):

A E Traynor-Kaplan ◽

B L Thompson ◽

A L Harris ◽

P Taylor ◽

G M Omann ◽

...

Keyword(s):

Transient Increase ◽

Human Neutrophils

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Clearance rate in relation to agglutinins for gelatin-stabilized colloid in the rat

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1963.204.4.655 ◽

1963 ◽

Vol 204 (4) ◽

pp. 655-659 ◽

Cited By ~ 8

Author(s):

I. MacKay Murray

Keyword(s):

Iron Oxide ◽

Clearance Rate ◽

Reticuloendothelial System ◽

Transient Increase ◽

Clearance Rates ◽

Time Intervals ◽

Thorium Dioxide ◽

Plasma Response ◽

Circulating Levels

Intravascular clearance rates of gelatin-stabilized gold were compared with circulating titers of gelatin agglutinins in rats at increasing time intervals after blockading injections of gelatin-stabilized gold and S. marcescens endotoxin. The degree and duration of reticuloendothelial system (RES) blockade against the homologous colloid were directly related to the circulating levels of gelatin agglutinins. In contrast, plasma agglutinins were not decreased in endotoxin-induced blockade against the gelatin-stabilized colloid. In a further experiment, the plasma response to blockading injections of colloidal thorium dioxide, iron oxide, and zymosan was characterized by a transient increase in gelatin agglutinins suggesting the nonspecific release of opsonins from an extravascular source. The findings indicated that clearance rates of gelatin-stabilized colloids were dependent on the total available opsonin in the rat rather than the total circulating opsonin. It is suggested that RES blockade is effected by the prior nonspecific depletion of opsonins from an extravascular reserve which is the major component of the total available opsonin.

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