FRI0053 ACCELERATED ATHEROSCLEROSIS IN PREMENOPAUSAL WOMEN WITH RHEUMATOID ARTHRITIS (15 YEARS PROSPECTIVE STUDY)

2020 ◽

Author(s):

Metka Koren Krajnc ◽

Radovan Hojs ◽

Iztok Holc ◽

Željko Knez ◽

Artur Pahor

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Inflammatory Markers ◽

Premenopausal Women ◽

Matrix Metalloproteases ◽

Accelerated Atherosclerosis ◽

Follow Up Study ◽

Laboratory Test Results ◽

Traditional Risk Factors

Rheumatoid arthritis (RA) is a chronic inflammatory disease, associated with increased mortality and morbidity due to the higher cardiovascular risk in these patients. Traditional risk factors are not the only answer for the accelerated atherosclerosis. In long term prospective study, we investigated the relationship between asymptomatic atherosclerosis and traditional risk factors as well as inflammatory markers in patients with RA and matched healthy controls. We studied the laboratory test results, the concentrations of inflammatory mediators, matrix metalloproteases (MMP) and inflammation markers in the total of 70 (60 at follow-up) premenopausal healthy women with RA and 40 (34 at follow-up) matched controls’. We used the B-mode ultrasound imaging of carotid arteries for detection of asymptomatic atherosclerosis. Correlation with different factors was evaluated. Statistically significant higher values of inflammatory markers such as selective adhesion molecules ICAM & VCAM, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and MMP-3 in patients` group were found in the follow-up study. More plaques were found in the patients’ group (42.4% vs. 12.9%; p=0.005), as compared with the controls’ group. The patients had also higher values of cIMT (p=0.001). Using bivariate regression analysis only VCAM was found as a prognostic factor for plaque occurrence (r= 0. 341, p=0.016), but not for cIMT (r= -0.130, p=0.327) in premenopausal female patients with RA after the follow-up. Therefore, the asymptomatic atherosclerosis is accelerated in premenopausal women with RA. The results of our follow-up study showed the association between the inflammation and accelerated atherosclerosis. Furthermore, VCAM was found to have statistically significant correlation with plaque occurrence in these patients.

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EVALUATION OF THE EFECTS OF ELECTRONIC ACUPUNCTURE COMBINED WITH “TAM TY THANG” REMEDY IN THE TREATMENT OF RHEUMATOID ARTHRITIS BY WIND-COLD-DAMP

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.6.17 ◽

2017 ◽

pp. 122-127

Author(s):

Thi Luu Nguyen ◽

Thi Tan Nguyen

Keyword(s):

Rheumatoid Arthritis ◽

Side Effects ◽

Prospective Study ◽

Key Words Rheumatoid Arthritis ◽

Good Effect ◽

Good Level ◽

Relieve Pain ◽

Level Of Activity ◽

Before And After ◽

The Moment

Objectives: To assess the effect of electronic acupuncture combined with “Tam ty thang” remedy in the treatment of rheumatoid arthritis by wind-cold-damp. Materials and methods: prospective study, comparing before and after treatment, including 43 patients who were diagnosed with rheumatoid arthritis by wind-cold-damp according to traditional medicine. Results: good level occupied 69,8%, and fair good level occupied 30,2%.The improved motor function accounted for 95.3%, to relieve pain up to 95,3%, reducing inflammation of VSS in 1 hour at the moment No 31,65, N28 17,88. The improvement in the level of activity of the hand reached 48,8% for good level. Conclusions: The method of electronic acupuncture combined with “Tam ty thang” remedy have a good effect in the treatment of rheumatoid arthritis by wind-cold-damp and it didn’t cause significantly side effects in clinic. Key words: rheumatoid arthritis, electronic acupuncture, “Tam ty thang” remedy

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