scholarly journals Response to: ‘Correspondence on ‘Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation’’ by Randelli et al

2021 ◽  
pp. annrheumdis-2020-219782
Author(s):  
Sanna Cederqvist ◽  
Tapio Flinkkilä ◽  
Jari Ylinen ◽  
Hannu Kautiainen ◽  
Antti Tuominen ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Rotator Cuff ◽  
Randomised Clinical Trial ◽  
Rotator Cuff Disease ◽  
Surgical Treatments

scholarly journals Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation

2020 ◽  
pp. annrheumdis-2020-219099
Author(s):  
Sanna Cederqvist ◽  
Tapio Flinkkilä ◽  
Markus Sormaala ◽  
Jari Ylinen ◽  
Hannu Kautiainen ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Rotator Cuff ◽  
Shoulder Function ◽  
Full Thickness ◽  
Rotator Cuff Disease ◽  
Link Type ◽  
And Function ◽  
Surgical Treatments ◽  
Non Surgical Treatment

BackgroundRotator cuff disease (RCD) causes prolonged shoulder pain and disability in adults. RCD is a continuum ranging from tendinopathy to full-thickness tendon tear. Recent studies have shown that subacromial decompression and non-surgical treatments provide equivalent results in RCD without a full-thickness tendon lesion. However, the importance of surgery for full-thickness tendon tears remains unclear.MethodsIn a pragmatic, randomised, controlled trial, 417 patients with subacromial pain underwent 3-month initial rehabilitation and MRI arthrography (MRA) for the diagnosis of RCD. Of these, 190 shoulders remained symptomatic and were randomised to non-surgical or surgical treatments. The primary outcomes were the mean changes in the Visual Analogue Scale for pain and the Constant Murley Score for shoulder function at the 2-year follow-up.ResultsAt the 2-year follow-up, both non-surgical and surgical treatments for RCD reduced pain and improved shoulder function. The scores differed between groups by 4 (95% CI −3 to 10, p=0.25) for pain and 3.4 (95% CI −0.4 to 7.1, p=0.077) for function. Among patients with full-thickness ruptures, the reduction in pain (13, 95% CI 5 to 22, p=0.002) and improvement in function (7.0, 95% CI 1.8 to 12.2, p=0.008) favoured surgery.ConclusionsNon-surgical and surgical treatments for RCD provided equivalent improvements in pain and function. Therefore, we recommend non-surgical treatment as the primary choice for patients with RCD. However, surgery yielded superior improvement in pain and function for full-thickness rotator cuff rupture. Therefore, rotator cuff repair may be suggested after failed non-surgical treatment.Trial registration detailsClinicalTrials.gov, NCT00695981 and NCT00637013.

scholarly journals Physical therapy plus general practitioners’ care versus general practitioners’ care alone for sciatica: a randomised clinical trial with a 12-month follow-up

2008 ◽  
Vol 17 (4) ◽  
pp. 509-517 ◽  
Author(s):  
Pim A. J. Luijsterburg ◽  
Arianne P. Verhagen ◽  
Raymond W. J. G. Ostelo ◽  
Hans J. M. M. van den Hoogen ◽  
Wilco C. Peul ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Physical Therapy ◽  
General Practitioners ◽  
Randomised Clinical Trial

scholarly journals Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2888 ◽  
Author(s):  
Negar Naderpoor ◽  
Aya Mousa ◽  
Luisa Fernanda Gomez Arango ◽  
Helen L. Barrett ◽  
Marloes Dekker Nitert ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Gut Microbiota ◽  
Randomised Clinical Trial ◽  
Vitamin D Supplementation ◽  
Faecal Microbiota ◽  
Lower Abundance ◽  
Α Diversity ◽  
Significant Difference

In animal studies, vitamin D supplementation has been shown to improve gut microbiota and intestinal inflammation. However, limited evidence exists on the effect of vitamin D supplementation on the human gut microbiota. We examined the effect of vitamin D supplementation on faecal microbiota in 26 vitamin D-deficient (25-hydroxyvitamin D (25(OH)D) ≤50 nmol/L), overweight or obese (BMI ≥25 kg/m2) otherwise healthy adults. Our study was ancillary to a community based double-blind randomised clinical trial, conducted between 2014 and 2016. The participants provided stool samples at baseline and after 100,000 international units (IU) loading dose of cholecalciferol followed by 4000 IU daily or matching placebo for 16 weeks. Faecal microbiota was analysed using 16S rRNA sequencing; V6–8 region. There was no significant difference in microbiome α-diversity between vitamin D and placebo groups at baseline and follow-up (all p > 0.05). In addition, no clustering was found based on vitamin D supplementation at follow-up (p = 0.3). However, there was a significant association between community composition and vitamin D supplementation at the genus level (p = 0.04). The vitamin D group had a higher abundance of genus Lachnospira, and lower abundance of genus Blautia (linear discriminate analysis >3.0). Moreover, individuals with 25(OH)D >75 nmol/L had a higher abundance of genus Coprococcus and lower abundance of genus Ruminococcus compared to those with 25(OH)D <50 nmol/L. Our findings suggest that vitamin D supplementation has some distinct effects on faecal microbiota. Future studies need to explore whether these effects would translate into improved clinical outcomes.

scholarly journals A Randomised Clinical Trial of a Meridian-Based Intervention for Food Cravings With Six-Month Follow-Up

2011 ◽  
Vol 28 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Peta Stapleton ◽  
Terri Sheldon ◽  
Brett Porter ◽  
Jennifer Whitty
Keyword(s):  
Clinical Trial ◽  
Psychological Symptoms ◽  
Randomised Clinical Trial ◽  
Repeated Measure ◽  
Delayed Effect ◽  
Obese Adults ◽  
Food Cravings ◽  
Group Data ◽  
Post Test

AbstractThis randomised, clinical trial tested whether The Emotional Freedom Technique (EFT) reduced food cravings. This study involved 96 overweight or obese adults who were allocated to the EFT treatment or 4-week waitlist condition. Degree of food craving, perceived power of food, restraint capabilities and psychological symptoms were assessed pre- and post- a 4-week treatment program (mixed method ANOVA comparative analysis), and at 6-month follow-up (repeated measure ANOVA with group data collapsed). EFT was associated with a significantly greater improvement in food cravings, the subjective power of food and craving restraint than waitlist from pre- to immediately post-test (p< .05). Across collapsed groups, an improvement in food cravings and the subjective power of food after active EFT treatment was maintained at 6 months, and a delayed effect was seen for craving restraint. Although there was a significant reduction in measures of psychological distress immediately after treatment (p< .05), there was no between-group difference. These findings are consistent with the hypothesis that EFT can have an immediate effect on reducing food cravings and can result in maintaining reduced cravings over time.

scholarly journals A randomised clinical trial evaluating the efficacy of physiotherapy after rotator cuff repair

2004 ◽  
Vol 50 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Kimberley Hayes ◽  
Karen A Ginn ◽  
Judie R Walton ◽  
Zoltan L Szomor ◽  
George AC Murrell
Keyword(s):  
Clinical Trial ◽  
Rotator Cuff ◽  
Rotator Cuff Repair ◽  
Randomised Clinical Trial ◽  
Cuff Repair
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