scholarly journals AB0100 EVALUATION OF PGA LEVEL FOR CLINICAL REMISSION WITH BOOLEAN CRITERIA, 10MM OR 20MM?

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1078.1-1079
Author(s):  
I. Yoshii
Keyword(s):  
Disease Activity ◽  
Patient Group ◽  
Clinical Remission ◽  
Global Assessment ◽  
Activity Index ◽  
T Test ◽  
Mean Values ◽  
Significant Difference ◽  
Remission Criteria ◽  
The Mean

Background:Patient’s global assessment (PGA) is one important component of Boolean composite criteria for remission in treat with rheumatoid arthritis (RA). However, PGA no more than 10mm is sometimes obstacle to attain clinical remission. In recent few years, one opinion that PGA no more than 20mm may be comparable as no more than 10mm.Objectives:The aim of this study is to analyze how difference of these PGA level affect disease activity and daily activities in living, and evaluate which is optimal for the remission with Boolean remission criteria from real world setting.Methods:RA patients who were followed up for more than three years in the institute were picked up in the study. Each patient was monitored with tenderness joint count (TJC), swollen joint count (SJC), PGA, evaluator’s global assessment (EGA), serum C-reactive protein level (CRP), calculated disease activity score with simplified disease activity index(SDAI), Health Assessment Questionnaire Disability Index (HAQ-DI), and pain score using visual analog scale (PS-VAS) every consulted time from the first encounter (Baseline). Patients were classified according to achievement of Boolean remission criteria. Group 1: a patient group who attained Boolean remission wih TJC≦1, SJC≦1, CRP≦1mg/dl, and PGA≦1 (G-1), Group 2: a patient group who could not attained the Boolean remission used in the G-1 evaluation, but could attained another Boolean remission with TJC≦1, SJC≦1, CRP≦1mg/dl, and PGA≦2 (G-2), and Group 3: a patient group who could not attain Boolean remission for neither criterion.Mean values of measured parameters at Baseline and after the Baseline were compared statistically with Student T-test. Mean values of the same parameters in the G-1 and G-2 at the time of attain Boolean remission for each criteria, mean values of each of these parameters thereafter, and changes of these parameters were compared statistically with Student T-test.Results:A total of 438 patients 385 in the G-1 group, 16 in the G-2 group, and 37 in the G-3 group, were recruited. In parameters at Baseline, level of TJC, SJC, PGA, EGA, SDAI, and HAQ-DI in the G-1 was significantly lower than in the G-3, whereas no significant differences in any parameters demonstrated between in the G-2 and G-3. Level of HAQ-DI, and PS-VAS after Baseline in the G-1 was lower than in the G-3, whereas no significant difference of these parameters after Baseline demonstrated between in the G-2 and G-3. TJC, SJC, PGA, and EGA demonstrated significant less level in the G-1 than in the other two groups. The mean SDAI score at the time of first achievement of Boolean remission in the G-1 and G-2 were 1.08 and 2.57, respectively. The mean value of SDAI score after remission in the G-1 and G-2 were 3.35 and 6.44, respectively. These values and PS-VAS including change of the SDAI score demonstrated significant difference between the two groups (p<0.01), whereas HAQ-DI in the two groups demonstrated no significant difference.Conclusion:These results suggested that setting PGA as no more than 10mm should be reasonable for the evaluation of clinical remission with the Boolean criteria.Disclosure of Interests:None declared

scholarly journals Validity and Risk of Adopting PGA ≤ 2 As A Remission Criteria of Boolean in Clinical Practice in Patient With Rheumatoid Arthritis

2021 ◽  
Author(s):  
Ichiro Yoshii ◽  
Tatsumi Chijiwa ◽  
Naoya Sawada
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Disease Activity ◽  
Clinical Remission ◽  
Global Assessment ◽  
Statistical Difference ◽  
Activity Index ◽  
Disease Activity Index ◽  
Remission Criteria ◽  
The Mean

Abstract Validity and risk of setting patient’s global assessment (PGA) ≤ 2 as a Boolean remission criteria substituting PGA ≤ 1 in treating rheumatoid arthritis (RA) was investigatedPatients were recruited from an area cohort, of whom attained Boolean remission (Boolean-1) or near remission with PGA ≤ 2 and the rest components were ≤ 1 (Boolean-2). Simplified disease activity index (SDAI) score was compared according to the criteria variations.A total of 517 patients were studied. Mean SDAI score of patients with Boolean-1 was significantly lower than that of patients with Boolean-2 at acquisition. The trend was evident in the patients who attained Boolean-1 remission. Mean SDAI score at acquisition, 6 months after, and 1 year after of patients who attained Boolean-2 first and then Boolean-1, was significantly inferior to that of patients who attained the remissions at the same time. The mean SDAI score at month 6 in the Boolean-2 was not SDAI remission at all.We concluded that setting PGA ≤ 2 as a remission criteria may not have statistical difference in disease activity from PGA ≤ 1, however, there was an determinant risk to misread that includes patient who losses clinical remission after acquisition.

American College of Rheumatology/European League Against Rheumatism Remission Criteria for Rheumatoid Arthritis Maintain Reliable Performance When Evaluated in 44 Joints

2013 ◽  
Vol 40 (8) ◽  
pp. 1254-1258 ◽  
Author(s):  
Yuko Kaneko ◽  
Harumi Kondo ◽  
Tsutomu Takeuchi
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Clinical Remission ◽  
Global Assessment ◽  
Activity Index ◽  
Disease Activity Index ◽  
University Hospital ◽  
Physician Global Assessment ◽  
Remission Criteria ◽  
The Mean

Objective.To investigate the performance of the new remission criteria for rheumatoid arthritis (RA) in daily clinical practice and the effect of possible misclassification of remission when 44 joints are assessed.Methods.Disease activity and remission rate were calculated according to the Disease Activity Score (DAS28), Simplified Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI), and a Boolean-based definition for 1402 patients with RA in Keio University Hospital. Characteristics of patients in remission were investigated, and the number of misclassified patients was determined — those classified as being in remission based on 28-joint count but as nonremission based on a 44-joint count for each definition criterion.Results.Of all patients analyzed, 46.6%, 45.9%, 41.0%, and 31.5% were classified as in remission in the DAS28, SDAI, CDAI, and Boolean definitions, respectively. Patients classified into remission based only on the DAS28 showed relatively low erythrocyte sedimentation rates but greater swollen joint counts than those classified into remission based on the other definitions. In patients classified into remission based only on the Boolean criteria, the mean physician global assessment was greater than the mean patient global assessment. Although 119 patients had ≤ 1 involved joint in the 28-joint count but > 1 in the 44-joint count, only 34 of these 119 (2.4% of all subjects) were found to have been misclassified into remission.Conclusion.In practice, about half of patients with RA can achieve clinical remission within the DAS28, SDAI, and CDAI; and one-third according to the Boolean-based definition. Patients classified in remission based on a 28-joint count may have pain and swelling in the feet, but misclassification of remission was relatively rare and was seen in only 2.4% of patients under a Boolean definition. The 28-joint count can be sufficient for assessing clinical remission based on the new remission criteria.

scholarly journals AB0669 PARTICULARITIES OF TUNISIAN FEMALE AXIAL SPONDYLOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1629.2-1629
Author(s):  
K. Ben Abdelghani ◽  
Y. Gzam ◽  
A. Fazaa ◽  
S. Miladi ◽  
K. Ouenniche ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Activity Index ◽  
Age At Onset ◽  
Disease Onset ◽  
Disease Activity Index ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean

Background:Axial spondyloarthritis (ax-SpA) is a chronic rheumatic disease that mainly affects men. However, the female form of ax-SpA remains insufficiently studied.Objectives:The aim of this study was to determine the clinical characteristics, the disease activity and the functional impact of female ax-SpA in comparison with male ax-SpA.Methods:This is a retrospective study including patients diagnosed with ax-SpA fulfilling the criteria of the Assessment of SpondyloArthritis international Society (ASAS) 2009.Clinical parameters, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath ankylosing spondylitis disease activity index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI) were compared between groups of female and male ax-SpA.Results:Two hundred ax-SpA patients were included with 31% of female (n=62) and a mean age of 43,3 ± 11,2 years.The mean age at onset of symptoms was 31,8 ± 8,9 years for women and 25,3 ± 9,1 years for men (p <0,0001). The mean age at diagnosis was 36,4 ± 9,6 years for women and 31,7 ± 10,4 years for men (p = 0,003). Ax-SpA with juvenile onset was noted in 1,7% of women and 12,1% of men (p = 0,02). Male ax-SpA were significantly more smokers (46.8% vs 5.4%; p <0.001). The mean duration of morning stiffness was 11,3 ± 9,2 minutes for women versus 21,6 ± 19,3 minutes for men (p = 0,005).The mean ESR was 42,4 ± 29,8 mm for women and 28,3 ± 23,4 mm for men (p = 0,001). Radiographic sacroiliitis was present in 69,3% of women versus 84,7% of men (p = 0,01). The use of anti-TNF alpha was less frequent in women (29% vs 48,5%; p = 0,01).Our study didn’t found a statistically significant difference in peripheral manifestations, extraarticular manifestations, CRP, BASDAI and BASFI between the two groups.Conclusion:Female ax-SpA seems to have a better prognosis than male with older age in disease onset, less inflammation, less radiographic sacroiliitis and less use of biological treatments.References:[1]Rusman T, et al. Curr Rheumatol Rep. 2018; 20(6).[2]Siar N, et al. Curr Rheumatol Rev. 2019;Disclosure of Interests:None declared

Effect of smoking on cardiovascular autonomic functions

2021 ◽  
Vol 9 (2) ◽  
pp. 3780-3784
Author(s):  
P.Vani ◽  
◽  
Sharan B Singh M ◽  
Keyword(s):  
Heart Rate ◽  
Autonomic Function ◽  
T Test ◽  
Resting Heart Rate ◽  
Autonomic Functions ◽  
Mean Values ◽  
Function Tests ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Introduction: Cigarette smoking is a prime risk factor for cardiovascular morbidity and mortality. Chronic smoking results in autonomic dysfunction leading to increased cardiovascular risk in smokers. The present study was planned to study the effect of smoking on the Cardiovascular Autonomic Functions among smokers. Materials and Methods: Fifty male subjects who were in the age group of 25 to 45 years. They were grouped into 25 smokers and 25 non-smokers. The participant subjects were selected among the staff members, residents and the patients from the routine OPD in SVIMS. Prior to study, they were informed about the procedure and the purpose of the study tests and written consents were obtained from them. The Cardiovascular Autonomic Function Tests were assessed by using a POLYGRAPH which was available in the department. Results and Conclusion: After applying the ‘t’-test for the difference between the two sample means, it was observed that there was a highly significant difference between the mean values of the BMI(i.e.p<0.01) and the para-sympathetic function tests among the smokers and the non – smokers(i.e.p<0.00). The Resting Heart Rate had significantly increased and the Deep breathing difference, the postural tachycardial index (Response to standing) and the Valsalva Ratio had significantly decreased in the smokers as compared to those in the non – smokers. After applying the ‘t’-test for the difference between the two sample means, it was observed that there was no significant difference between the mean values of the Postural hypotension test (i.e. p>0.05) and that there was a highly significant difference between the mean values of the Sustained handgrip test in the smokers and the non – smokers (i.e. p<0.00). KEY WORDS: Cardiovascular autonomic function tests, Smoking, Resting heart rate.

scholarly journals Pregnancy outcomes between pregnant systemic lupus erythematosus patients with clinical remission and those with low disease activity: A comparative study

2021 ◽  
Author(s):  
Worawit Louthrenoo ◽  
Thananant Trongkamolthum ◽  
Nuntana Kasitanon ◽  
Antika Wongthanee
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Clinical Remission ◽  
Activity Index ◽  
Physician Global Assessment ◽  
Systemic Lupus ◽  
Low Disease Activity ◽  
Significant Difference

Objectives: This study aims to compare pregnancy outcomes between systemic lupus erythematosus (SLE) patients who attained clinical remission based on the Definition of Remission in SLE (DORIS) and those with lupus low disease activity based on Low Lupus Disease Activity State (LLDAS). Patients and methods: Between January 1993 and June 2017, a total of 90 pregnancies (one twin pregnancy) from 77 patients (mean age: 6.9±4.8 years; range, 17.9 to 37.3 years) were included in the study. The clinical remission and the LLDAS groups were modified into modified clinical remission and LLDAS groups, respectively by omitting Physician Global Assessment (PGA). The clinical SLE disease activity index (cSLEDAI) score was used for LLDAS. Results: Pregnancies in 49 patients occurred, when they were in modified clinical remission and in 57 in modified LLDAS. There was no significant difference in demographic characteristics, disease activity, or medication received at conception between the two groups. Pregnancy outcomes were similar between the modified clinical remission and the modified LLDAS groups in terms of successful pregnancy (83.67% vs. 84.21%), full-term births (38.78% vs. 38.60%), fetal losses (16.33% vs. 15.79%), spontaneous abortions (14.29% vs. 14.04%), small for gestational age infants (18.37% vs. 19.30%), low birth weight infants (42.86% vs. 40.35%), maternal complications (46.94% vs. 49.12%), and maternal flares (36.73% vs. 40.35%). The agreement of pregnancy outcomes was very high between the two groups (91.11% agreement). Conclusion: Pregnancy outcomes in SLE patients who achieved modified clinical remission and modified LLDAS were comparable.

scholarly journals A novel method using 3D CBCT to assess anterior malar prominence among native Bangalore population- A descriptive study

2021 ◽  
Vol 7 (3) ◽  
pp. 223-228
Author(s):  
Sanda Aamani ◽  
Hemanth M ◽  
Sharmada B K ◽  
Karthik J Kabbur ◽  
Goutham Kalladka
Keyword(s):  
Descriptive Study ◽  
T Test ◽  
Linear Measurements ◽  
Mean Values ◽  
Significant Difference ◽  
The Face ◽  
Novel Method ◽  
Males And Females ◽  
The Mean ◽  
Paired T Test

There is a lack of accurate three-dimensional studies to locate malar prominence for specified population, this study aims to locate the malar prominence using stable landmarks using CBCT. To derive a novel method to accurately locate the malar prominence and to assess and compare the malar prominence between males and females among Bangalore population using 3D CBCT study. All CBCT scans of study subjects belong to Bangalore population were collected from the pre-existing data available in Radiology imaging Solutions (CBCT centre), Bangalore during the period of September 10th to October 10th 2020. This is a descriptive study. A total of 42 subjects including 21 Males and 21 females were assessed using full skull CBCT scans which were converted to DICOM format and reconstructed into 3D images using NEMOCEPH 3D software. Landmarks used to locate the malar prominence were Fzs, Z, Zm and Ans. The intersection of these landmarks is considered to be as constructed maxillozygion(My). For the accuracy of the constructed Maxillozygion point (My), the distance between the actual Maxillozygion (Mzy) and constructed Maxillozygion (My) is measured and calculated between left and right halves of males and females. Three Orthogonal planes constructed were Midsagittal, Axial and Coronal Planes and the linear measurements with reference to all three reference planes in both the groups are measured. Student paired t- Test, Independent Student t Test, Mann Whitney Test. The mean distance from Mzy and my between right and left half of the face was compared using student paired t- Test. There is no significant difference (p=0.35).The mean values of the constructed anatomical landmark (maxillozygion) coordinated to three orthogonal planes between right and left sides of the face is compared using student paired T test and for both the genders (males and females) was compared using Independent Student t Test, and it is significantly higher in males as compared to females and it is statistically significant at (p=0.01). The location of malar prominence using CBCT by a novel method for Bangalore population is found which can be helpful in diagnosis and treatment planning for malar augmentation, camouflage treatment in subjects with midface deficiencies.

Neurocognitive outcome and ventricular volume in children with myelomeningocele treated for hydrocephalus in Uganda

2009 ◽  
Vol 4 (6) ◽  
pp. 564-570 ◽  
Author(s):  
Benjamin Warf ◽  
Solomon Ondoma ◽  
Abhaya Kulkarni ◽  
Ruth Donnelly ◽  
Miriam Ampeire ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Ventricular Volume ◽  
T Test ◽  
Neurocognitive Outcome ◽  
Mean Values ◽  
Vp Shunt ◽  
Significant Difference ◽  
Neurocognitive Outcomes ◽  
The Mean ◽  
Better Than

Object Despite lower failure and infection rates compared with shunt placement, it has not been known whether endoscopic third ventriculostomy/choroid plexus cauterization (ETV/CPC) might be inferior in regard to neurocognitive development. This study is the first to describe neurocognitive outcome and ventricle volume in infants with hydrocephalus due to myelomeningocele that was treated primarily by ETV/CPC. Methods The modified Bayley Scales of Infant Development (BSID-III) test was administered to 93 children with spina bifida who were 5–52 months of age. Fifty-five of these children had been treated by ETV/CPC, 19 received ventriculoperitoneal (VP) shunts, and 19 had required no treatment for hydrocephalus. Raw scores were converted to scaled scores for comparison with age-corrected norms. Ventricular volume was assessed by frontal/occipital horn ratio (FOR) calculated from late postoperative CT scans. The mean values between and among groups of patients were compared using independent samples t-test and ANOVA. The comparison of mean values to population normal means was performed using the single-sample t-test. Linear regression analyses were performed using BSID scores as the dependent variables, with treatment group and ventricular size (FOR) as the independent variables. Probability values < 0.05 were considered significant. Results . There was no significant difference in mean age at assessment among groups (p = 0.8). The mean scale scores for untreated patients were no different from normal (all p > 0.27) in all portions of the BSID (excluding gross motor), and were generally significantly better than those for both VP shunt–treated and ETV/CPC groups. The ETV/ CPC-treated patients had nonsignificantly better mean scores than patients treated with VP shunts in all portions of the BSID (all p > 0.06), except receptive communication, which was significantly better for the ETV/CPC group (p = 0.02). The mean FOR was similar among groups, with no significant difference between the untreated group and either the VP shunt or ETV/CPC groups. The FOR did not correlate with performance. Conclusions The ETV/CPC and VP shunt groups had similar neurocognitive outcomes. Neurocognitive outcomes for infants not requiring treatment for hydrocephalus were normal and significantly better than in those requiring treatment. The mean ventricular volume was similar among all 3 groups, and significantly larger than normal. There was no association between FOR and performance. Stable mild-to-moderate ventriculomegaly alone should not trigger intervention in asymptomatic infants with spina bifida.

scholarly journals INFLUÊNCIA DA DISTÂNCIA NA EXATIDÃO DA CUBAGEM NÃO DESTRUTIVA DE QUALEA SP. NO BIOMA AMAZÔNIA

Nativa ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 663-670
Author(s):  
Rafaella De Angeli Curto ◽  
Arthur Faganello Teodoro Dos Anjos ◽  
Emanuel José Gomes De Araújo ◽  
Charlote Wink ◽  
Sintia Valerio Kohler
Keyword(s):  
Residual Analysis ◽  
T Test ◽  
Mean Values ◽  
Significant Difference ◽  
Standing Trees ◽  
The Mean ◽  
Dependent Samples ◽  
Non Destructive

Objetivou-se avaliar o efeito da distância na exatidão do dendrômetro digital Criterion RD 1000®, na estimativa do diâmetro e volume de Qualea sp. no bioma Amazônia. Foram selecionadas 30 árvores e cubadas pelo método de Smalian até a altura comercial com escalada e com Criterion RD 1000®, nas distâncias entre observador e a árvore de 11 m, 13 m, 15 m e à maior distância que o observador conseguiu instalar o equipamento em relação a árvore. Para avaliar o diâmetro ao longo do fuste, o volume comercial e por segmento, realizou-se o teste t pareado, com 95% de probabilidade, a análise de resíduos e as estatísticas complementares. Não houve diferença significativa entre os valores médios das variáveis analisadas, obtidos com a escalada e os estimados pelo Criterion. Houve menor amplitude dos resíduos nas seções inferiores do fuste com tendência em subestimar os menores diâmetros. As estatísticas complementares demonstraram maiores erros quando o equipamento estava mais próximo da árvore e menores quando estava a 15 m, correspondendo a uma distância superior à média da altura comercial das árvores. O equipamento permitiu estimar com exatidão diâmetros e volumes de árvores em pé, viabilizando a cubagem não destrutiva de Qualea sp. no bioma Amazônia.  Palavras-chave: mensuração; volumetria; Criterion RD 1000®.   INFLUENCE OF DISTANCE ON THE ACCURACY OF THE NON-DESTRUCTIVE OF Qualea sp. IN THE AMAZON BIOME   ABSTRACT: The objective was to evaluate the effect of distance on the accuracy of the digital dendrometer Criterion RD 1000®, on the estimate of the diameter and volume of Qualea sp. in the Amazon biome. Thirty trees were selected and scaled by the Smalian method to commercial height with climbing and with a Criterion RD 1000®, in the distances between the observer and the 11 m, 13 m, 15 m and the longest distance that the observer managed to install the equipment in relation to the tree. To analyze diameter along the stem, commercial volume and volume per segment, the t test for dependent samples was performed, with a 95% probability, as well as residual analysis and complementary statistics. There was no significant difference between the mean values ​​of the variables analyzed, obtained with the climb and estimated with a Criterion. There was a smaller amplitude of residues in the lower sections of the stem with tendency to underestimate smaller diameters. The complementary statistics showed greater errors with the equipment closest to the tree and smaller when it was 15 m away, corresponding to a distance greater than the average commercial height of the trees. The equipment made it possible to accurately estimate the diameters and volumes of standing trees, enabling the non-destructive scaling of Qualea sp. in the Amazon biome forest. Keywords: measurement; volumetry; Criterion RD 1000®.

scholarly journals AB0509 FREQUENCY AND RISK FACTORS OF HIP INVOLVEMENT DURING SPONDYLOARTHRITIS IN MILITARY PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1281.3-1282
Author(s):  
L. Kharrat ◽  
M. Slouma ◽  
S. Rahmouni ◽  
R. Dhahri ◽  
I. Gharsallah ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Activity Index ◽  
Physical Stress ◽  
Military Hospital ◽  
Functional Impact ◽  
Mean Delay ◽  
Significant Difference ◽  
The Mean ◽  
Military Patients

Background:Hip involvement can reveal a spondyloarthritis (SA) or appear later. It hampers patient’s life quality and can be responsible of significant handicap (1). Military patients are a special population. They are more exposed to physical stress which makes their SA characteristics quite different to other patients.Objectives:We aimed to determine the frequency of hip involvement in SA and to study its characteristics and associated factors in military patients.Methods:We conducted a cross-sectional study carried out in Rheumatology department of Military Hospital of Instruction of Tunis over a 10-year period (2010-2020) including SA patients meeting The Assessment of SpondyloArthritis international Society (ASAS). For each patient we collected the following informations: age, characteristics of hip involvement, ASDAS (Ankylosing Spondylitis Disease Activity Score), BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASMI (Bath Ankylosing Spondylitis Metrology Index) and BASRI (Bath Ankylosing Spondylitis Radiology Index). We also measured Erythrocyte Sedimentation rate (ESR) and C-reactive protein (CRP).Results:One hundred forty-one patients were included. They were 103 men and 38 women. The mean age was 43.01± 12.9 years. The mean age at the onset was 34.28±12.05 years. The mean delay of the disease was 9.16±8.98 years.The mean BASDAI and l’ASDAS-CRP were 3.89±2.29 and 3.07±1.83, respectively.Hip involvement was noted in 35.5% of the cases (n=50). It was bilateral in 41 of the cases. The number of affected hips was thus 91. The mean delay between the onset of SA and the discovery of hip involvement was 32.24±53.58 months [0-264 months].A significant difference was noted in the axial mobility between patients who have hip involvement and those who don’t (BASMI was 3,8±2.45 versus 1,45±1.8, p<0.0001).Moreover, functional impact was higher in patients with hip involvement (BASFI was 5.7±2.24 versus 3.45±2.86, p<0.0001).Patients with hip involvement had significantly higher BASRI compared to patients with no hip involvement (5.79±3.17 versus 3.14±2.42, p<0.0001).However, no difference was found between patients who have hip involvement and those who don’t with these following parameters: ESR, CRP, BASDAI and ASDAS-CRP.Conclusion:Our study showed that hip involvement is quite common in military SA patients. It is responsible of an important functional impact and it seems to be associated to a major limitation of axial mobility. Nevertheless, hip involvement was not associated neither to inflammation parameters levels nor to the disease activity, this suggest that hip involvement may progress independently of the disease activity in military patients due to physical stress and micro traumas.References:[1]López-Medina C, Castro-Villegas MC, Collantes-Estévez E. Hip and ShoulderInvolvement and Their Management in Axial Spondyloarthritis: a Current Review. CurrRheumatol Rep. sept 2020;22(9):53.Disclosure of Interests:None declared.

scholarly journals AB0102 EVALUATOR’S GLOBAL ASSESSMENT REFLECTS DISEASE ACTIVITY BUT NOT LINEARLY CORRELATES WITH DAILY ACTIVITY OR QUALITY OF LIFE COMPARED TO PATIENT’ GLOBAL ASSESSMENT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1079.2-1079
Author(s):  
I. Yoshii
Keyword(s):  
Quality Of Life ◽  
Disease Activity ◽  
Daily Activity ◽  
Global Assessment ◽  
Remission Rate ◽  
Objective Assessment ◽  
Mean Value ◽  
Mean Values ◽  
Significant Difference

Background:Evaluator’s global assessment (EGA) is the one component of indexed disease activity evaluation assessed by the rheumatologist for treatment of rheumatoid arthritis (RA). It does not included in the Boolean remission criteria nor 28-joints disease activity score (DAS28), however it is widely recognized among rheumatologist as an only comprehensive and objective assessment parameter.Objectives:The aim of this study is to evaluate how EGA correlates with other components and the influence of EGA on disease activity and daily activity, and quality of life.Methods:A total of 24,075 times of monitoring out of 683 RA patients who were followed up for more than three consecutive years was performed. Contents of monitoring included tenderness joint count (TJC), swollen joint count (SJC), patient’s global assessment (PGA), EGA, C-reactive protein (CRP), and calculated values of DAS28, SDAI, composite index of Boolean evaluation, pain score with visual analog scale (PS-VAS), Health Assessment Questionnaire Disability Index (HAQ-DI), and quality of life score (QOLS) calculated from Euro-QOL questionnaire with 5th dimensions. Each measurement was classified with the EGA score divided by one increment from zero to ten. Mean values of DAS28, CDAI, SDAI, remission rate of these indices and Boolean remission rate, and mean values of PS-VAS, HAQ-DI, and QOLS were statistically evaluated. Results were compared to the results that was analyzed in according to the PGA score substituted with the EGA score.Moreover, EGA at the time of Boolean remission of the patients who achieved Boolean remission at least once during treating were picked up. Patients were classified according to the EGA level with 0.5 increment from zero. Mean value of TJC, SJC, PGA, EGA, SDAI, Boolean remission rate, HAQ-DI, and PS-VAS after attaining Boolean remission were compared statistically.Results:Number of measures counted 15424, 2001, 3688, 1731, 664, 293, 144, 88, 29, 2, and 11 for each level of EGA. The EGA score tended to concentrate more in zero to two in comparing to the PGA score. Mean DAS28, CDAI, and SDAI demonstrated significant increase as the EGA level increased, and remission rate of the all indices including Boolean demonstrated significant decrease as the EGA level increases (p<0.01%). CDAI, SDAI, and Boolean remission rate demonstrated zero percent from two. Mean value of PS-VAS and HAQ-DI score demonstrated also significant decrease as the EGA level increases, and QOLS demonstrated significant decrease as the EGA level increases (p<0.01%). However, these tendency showed more irregular compared to that analyzed with the PGA score. Correlation coefficients with regarding to the EGA score was always less than that with regarding to the PGA score.In the patients who achieved Boolean remission, EGA levels were divided with 294 with zero (G-0) and 118 with 0.5 (G-.5), whereas 71 could not achieve Boolean remission. Average TJC (p<0.05), SJC (p<0.001), EGA (p<0.001), CRP (p<0.05), and SDAI (p<0.01) level in the G-0 group demonstrated significant less than in the G-.5 group, whereas PGA, Boolean remission rate, HAQ-DI, and PS-VAS demonstrated no significant difference in between the two groups.Conclusion:It is more reliable to estimate daily activity and quality of life from the PGA score than to estimate from the EGA score. EGA correlates with SJC and CRP more strongly than with TJC and CRP. EGA does not reflect HAQ-DI and PS-VAS.Disclosure of Interests:None declared

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