scholarly journals One-year outcomes of infants born with congenital diaphragmatic hernia: a national population cohort study

2019 ◽  
Vol 104 (6) ◽  
pp. F643-F647 ◽  
Author(s):  
Anna-May Long ◽  
Kathryn J Bunch ◽  
Marian Knight ◽  
Jennifer J Kurinczuk ◽  
Paul Damian Losty
Keyword(s):  
Cohort Study ◽  
Infant Mortality ◽  
Congenital Diaphragmatic Hernia ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Primary Closure ◽  
Postoperative Morbidity ◽  
Patch Repair ◽  
Factors Associated ◽  
High Incidence

ObjectiveTo report outcomes to 1 year, in infants born with congenital diaphragmatic hernia (CDH), explore factors associated with infant mortality and examine the relationship between surgical techniques and postoperative morbidity.DesignProspective national population cohort study.SettingPaediatric surgical centres in the UK and Ireland.MethodData were collected to 1 year for infants with CDH live-born between 1 April 2009 to 30 September 2010. Factors associated with infant mortality are explored using logistic regression. Postoperative morbidity following patch versus primary closure, minimally invasive versus open surgery and biological versus synthetic patch material is described. Data are presented as n (%) and median (IQR).ResultsOverall known survival to 1 year was 75%, 95% CI 68% to 81% (138/184) and postoperative survival 93%, 95% CI 88% to 97% (138/148). Female sex, antenatal diagnosis, use of vasodilators or inotropes, being small for gestational age, patch repair and use of surfactant were all associated with infant death. Infants undergoing patch repair had a high incidence of postoperative chylothorax (11/54 vs 2/96 in infants undergoing primary closure) and a long length of hospital stay (41 days, IQR 24–68 vs 16 days, IQR 10–25 in primary closure group). Infants managed with synthetic patch material had a high incidence of chylothorax (11/34 vs 0/19 with biological patch).ConclusionThe majority of infant deaths in babies born with CDH occur before surgical correction. Female sex, being born small for gestational age, surfactant use, patch repair and receipt of cardiovascular support were associated with a higher risk of death. The optimum surgical approach, timing of operation and choice of patch material to achieve lowest morbidity warrants further evaluation.

scholarly journals Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort study

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172533 ◽  
Author(s):  
Alberto L. García-Basteiro ◽  
Llorenç Quintó ◽  
Eusebio Macete ◽  
Azucena Bardají ◽  
Raquel González ◽  
...  
Keyword(s):  
Cohort Study ◽  
Infant Mortality ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Mortality And Morbidity

Early-Onset Thrombocytopenia in Small-for-Gestational-Age Neonates: A Retrospective Cohort Study

2016 ◽  
Vol 33 (S 01) ◽  
Author(s):  
S. Fustolo-Gunnink ◽  
R. Vlug ◽  
V. Smits-Wintjens ◽  
E. Heckman ◽  
A. Te Pas ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Retrospective Cohort Study ◽  
Early Onset ◽  
Retrospective Cohort

The effects of labor on infant mortality among small-for-gestational-age infants in the USA

2002 ◽  
Vol 12 (3) ◽  
pp. 201-206 ◽  
Author(s):  
W. L. Kinzler ◽  
C. V. Ananth ◽  
J. C. Smulian ◽  
A. M. Vintzileos
Keyword(s):  
Infant Mortality ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
The Usa

126. Sex and growth specific characteristics of small for gestational age neonates: A prospective cohort study

2018 ◽  
Vol 13 ◽  
pp. S24-S25
Author(s):  
Eva van der Vlugt ◽  
Petra Verburg ◽  
Shalem Leemaqz ◽  
Lesley Mccowan ◽  
Lucilla Poston ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prospective Cohort

scholarly journals Reduced prevalence of small-for-gestational-age and preterm birth for women of low socioeconomic position: a population-based cohort study comparing antenatal midwifery and physician models of care

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e022220 ◽  
Author(s):  
Daphne N McRae ◽  
Patricia A Janssen ◽  
Saraswathi Vedam ◽  
Maureen Mayhew ◽  
Deborah Mpofu ◽  
...  
Keyword(s):  
British Columbia ◽  
Cohort Study ◽  
Preterm Birth ◽  
Gestational Age ◽  
Socioeconomic Position ◽  
Small For Gestational Age ◽  
Models Of Care ◽  
Midwifery Care ◽  
Low Socioeconomic ◽  
Lower Odds

ObjectiveOur aim was to investigate if antenatal midwifery care was associated with lower odds of small-for-gestational-age (SGA) birth, preterm birth (PTB) or low birth weight (LBW) compared with general practitioner (GP) or obstetrician (OB) models of care for women of low socioeconomic position.SettingThis population-level, retrospective cohort study used province-wide maternity, medical billing and demographic data from British Columbia, Canada.ParticipantsOur study included 57 872 pregnant women, with low socioeconomic position, who: were residents of British Columbia, Canada, carried a singleton fetus, had low to moderate medical/obstetric risk, delivered between 2005 and 2012 and received medical insurance premium assistance.Primary and secondary outcome measuresWe report rates, adjusted ORs (aOR), and 95% CIs for the primary outcome, SGA birth (<the 10th percentile), and secondary outcomes, PTB (<37 weeks’ completed gestation) and LBW (<2500 g).ResultsOur sample included 4705 midwifery patients, 45 114 GP patients and 8053 OB patients. Odds of SGA birth were reduced for patients receiving antenatal midwifery versus GP (aOR 0.71, 95% CI 0.62 to 0.82) or OB care (aOR 0.59, 95% CI 0.50 to 0.69). Odds of PTB were lower for antenatal midwifery versus GP (aOR 0.74, 95% CI 0.63 to 0.86) or OB patients (aOR 0.53, 95% CI 0.45 to 0.62). Odds of LBW were reduced for midwifery versus GP (aOR 0.66, 95% CI 0.53 to 0.82) or OB patients (aOR 0.43, 95% CI 0.34 to 0.54).ConclusionAntenatal midwifery care in British Columbia, Canada, was associated with lower odds of SGA birth, PTB and LBW, for women of low socioeconomic position, compared with physician models of care. Results support the development of policy to ensure antenatal midwifery care is available and accessible for women of low socioeconomic position. Future research is needed to determine the underlying mechanisms linking midwifery care to better birth outcomes for women of low socioeconomic position.

scholarly journals Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A Retrospective Cohort Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154853 ◽  
Author(s):  
S. F. Fustolo-Gunnink ◽  
R. D. Vlug ◽  
V. E. H. J. Smits-Wintjens ◽  
E. J. Heckman ◽  
A. B. te Pas ◽  
...  
Keyword(s):  
Cohort Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Retrospective Cohort Study ◽  
Early Onset ◽  
Retrospective Cohort

scholarly journals Longitudinal changes of cardiotocographic parameters throughout pregnancy: a prospective cohort study comparing small-for-gestational-age and normal fetuses from 24 to 40 weeks

2017 ◽  
Vol 45 (4) ◽  
Author(s):  
Célia Amorim-Costa ◽  
A. Rita Gaio ◽  
Diogo Ayres-de-Campos ◽  
João Bernardes
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prospective Cohort ◽  
Parallel Increase ◽  
Fetal Malformations ◽  
First Time

AbstractObjective:To compare longitudinal trends of cardiotocographic (CTG) parameters between small-for-gestational-age (SGA) and normal fetuses, from 24 to 41 weeks of pregnancy.Methods:A prospective cohort study was carried out in singleton pregnancies without fetal malformations. At least one CTG was performed in each of the following intervals: 24–26 weeks+6 days, 27–29 weeks+6 days, 30–32 weeks+6 days, 33–35 weeks+6 days, 36–38 weeks+6 days and ≥39 weeks. Tracings were analyzed using the Omniview-SisPortoResults:A total of 176 fetuses (31 SGA) and 1256 tracings (207 from SGA fetuses) were evaluated. All CTG parameters changed significantly throughout pregnancy in the three groups, with a decreasing baseline and probability of decelerations, and an increasing average long-term variability (LTV), average short-term variability (STV) and accelerations. Baseline showed a more pronounced decrease (steeper slope) in SGA fetuses, being higher in these cases at earlier gestational ages and lower later in pregnancy. Average LTV was significantly lower in SGA<p3 fetuses, but a parallel increase occurred in all groups. There was a considerable inter-fetal variability within each group.Conclusion:A unique characterization of CTG trends throughout gestation in SGA fetuses was provided. A steeper descent of the baseline was reported for the first time. The findings raise the possibility of clinical application of computerized CTG analysis in screening and management of fetal growth restriction.

Sign in / Sign up

Export Citation Format

Share Document