Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria

ObjectivesTo investigate whether body mass index (BMI) trajectory, lifestyle and reproductive factors are associated with knee pain risk among middle-aged women.DesignProspective study of the Japan Nurses’ Health Study (JNHS).SettingThe JNHS investigates the health of female nurses in Japan. Biennial follow-up questionnaires are mailed to the participants.ParticipantsThe 7434 women aged over 40 years who responded to the 10-year self-administered follow-up questionnaire.Primary outcome measureSelf-reported knee pain at the 10-year follow-up was the primary outcome. We analysed BMI (normal or overweight) trajectory data from a baseline survey to the 10-year follow-up survey using group-based trajectory modelling. Exposure measurements were BMI trajectory, BMI at age 18 years, lifestyle variables and reproductive history.ResultsBMI trajectories from baseline to the 10-year follow-up were divided into four groups: remained normal, remained overweight, gained weight or lost weight. At the 10-year follow-up, 1281 women (17.2%) reported knee pain. Multivariable logistic regression analysis revealed that compared with the remained normal group, multivariable-adjusted ORs (95% CI) of knee pain were 1.93 (1.60 to 2.33) for the remained overweight group, 1.60 (1.23 to 2.08) for the gained weight group and 1.40 (0.88 to 2.21) for the lost weight group. The attributable risk percent (95% CI) of the remained overweight group was 48.1% (37.3% to 57.0%) compared with the reference group of remained normal. Alcohol intake at baseline was significantly associated with knee pain.ConclusionsThe lost weight group had a lower risk than the remained overweight group and the gained weight group and did not carry statistically significant risks for knee pain. Weight reduction and maintaining a normal BMI in middle age was important for preventing knee pain in women.

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The MRI definition of knee osteoarthritis: comparison with radiography and association with knee pain in middle-aged women

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2013.02.384 ◽

2013 ◽

Vol 21 ◽

pp. S180-S181

Author(s):

D. Schiphof ◽

E.H. Oei ◽

A. Hofman ◽

H. Weinans ◽

S. Bierma-Zeinstra

Keyword(s):

Knee Osteoarthritis ◽

Knee Pain ◽

Middle Aged ◽

Definition Of

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Effects of changes in obesity and exercise on the development of diabetes and return to normal fasting plasma glucose levels at one-year follow-up in middle-aged subjects with impaired fasting glucose

Environmental Health and Preventive Medicine ◽

10.1007/bf02897959 ◽

2001 ◽

Vol 6 (2) ◽

pp. 127-131 ◽

Cited By ~ 4

Author(s):

Shin'ichi Shimizu ◽

Yuichi Kawata ◽

Norito Kawakami ◽

Hideyasu Aoyama

Keyword(s):

Impaired Fasting Glucose ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Fasting Glucose ◽

Middle Aged ◽

Glucose Levels ◽

Fasting Plasma ◽

Aged Subjects ◽

One Year

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Effects and safety of platelet-rich plasma (PRP) and hyaluronic acid (HA), alone and in combination, in the treatment of knee osteoarthritis: A systematic review and meta-analysis.

10.21203/rs.2.23232/v1 ◽

2020 ◽

Author(s):

Jinlong Zhao ◽

Hetao Huang ◽

Guihong Liang ◽

Ling-feng Zeng ◽

Weiyi Yang ◽

...

Keyword(s):

Hyaluronic Acid ◽

Knee Osteoarthritis ◽

Knee Pain ◽

Platelet Rich Plasma ◽

Meta Analysis ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Womac Function ◽

Lequesne Index

Abstract Background Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of PRP combined with HA in the treatment of KOA compared with intra-articular injection of PRP or HA alone. Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Two orthopaedic surgeons conducted the literature retrieval and extracted the data. Outcome indicators include the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Lequesne Index, the visual analogue scale (VAS) for pain, and adverse events (AEs). Results Seven studies (5 randomized controlled trials, 2 cohort studies) with a total of 941 patients were included. In the VAS comparison after 6 months of follow-up, PRP combined with HA was more likely to reduce knee pain than PRP alone (standardized mean difference (SMD): -0.31; 95% confidence interval (CI): -0.55 to -0.06; P=0.01 <0.05). PRP combined with HA for KOA achieved better improvement in WOMAC Function Score (SMD: -0.32; 95% CI: -0.54 to -0.10) and WOMAC Total Score (SMD: -0.42; 95% CI: -0.67 to -0.17) at the 12-month follow-up than the application of PRP alone. In a comparison of Lequesne Index scores at a 6-month follow-up, PRP combined with HA improved knee pain scores more than PRP alone (SMD: -0.42; 95% CI: -0.67 to -0.17). In terms of AEs, PRP combined with HA was not significantly different from PRP or HA alone (P>0.05). Conclusions Compared with intra-articular injection of PRP alone, PRP combined with HA can improve WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores. However, in terms of the incidence of AEs, PRP combined with HA was not significantly different from PRP or HA alone.

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