High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study

Objectives:Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. The association of BMD with incident and progressive tibiofemoral OA was tested in a large prospective study of men and women aged 50–79 years with or at risk for knee OA.Methods:Baseline and 30-month weight-bearing posteroanterior and lateral knee radiographs were scored for Kellgren-Lawrence (K-L) grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade ⩾2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident and progressive OA was analysed using logistic regression, adjusting for covariates.Results:The mean (SD) age of 1754 subjects was 63.2 (7.8) years and body mass index was 29.9 (5.4) kg/m2. In knees without baseline OA, higher femoral neck and whole body BMD were associated with an increased risk of incident OA and increases in grade of JSN and osteophytes (p<0.01 for trends); adjusted odds were 2.3–2.9-fold greater in the highest compared with the lowest BMD quartiles. In knees with existing OA, progression was not significantly related to BMD.Conclusions:In knees without OA, higher systemic BMD was associated with a greater risk of the onset of JSN and K-L grade ⩾2. The role of systemic BMD in early knee OA pathogenesis warrants further investigation.

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Labyrinthectomy decreases bone mineral density in the femoral metaphysis in rats

Journal of Vestibular Research ◽

10.3233/ves-2004-14501 ◽

2004 ◽

Vol 14 (5) ◽

pp. 361-365

Author(s):

Régis Levasseur ◽

Jean Pierre Sabatier ◽

Olivier Etard ◽

Pierre Denise ◽

Annie Reber

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Weight Bearing ◽

Whole Body ◽

X Rays ◽

Mineral Density ◽

Femoral Metaphysis ◽

Significant Difference ◽

Distal Femoral Metaphysis ◽

Vestibular Influence

To determine whether the vestibular system could influence bone remodeling in rats, we measured bone mineral density with dual energy X-rays absorptiometry before and 30 days after bilateral labyrinthectomy. Comparatively to intact control rats, labyrinthectomized animals showed a reduced bone mineral density in distal femoral metaphysis (p = 0.007): the variations between D0 and D30 were +3.0% for controls and -13.9% for labyrinthectomized rats. No significant difference between the 2 groups was observed in the whole body mineral density. These results suggest that the peripheral vestibular apparatus is a modulator of bone mass and more specifically in weight bearing bone. We discuss possible mechanisms of this vestibular influence probably mediated by the sympathetic nervous system.

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Complex genetic regulation of bone mineral density and insulin-like growth factor-I in C57BL/6J-Chr #A/J/NaJ chromosome substitution strains

Physiological Genomics ◽

10.1152/physiolgenomics.90203.2008 ◽

2008 ◽

Vol 35 (2) ◽

pp. 159-164 ◽

Cited By ~ 3

Author(s):

K. E. Govoni ◽

L. R. Donahue ◽

C. Marden ◽

S. Mohan

Keyword(s):

Bone Mineral Density ◽

Growth Factor ◽

Bone Mineral ◽

Whole Body ◽

Insulin Like Growth Factor ◽

Chromosome Substitution ◽

Mineral Density ◽

Increased Risk ◽

Igf I ◽

Chromosome Substitution Strains

Low bone mineral density (BMD) is a phenotype associated with osteoporosis and increased risk of fracture. Since 60–80% of variation in BMD is associated with genetic factors, we used the novel approach of chromosome substitution strains (CSS) to identify chromosomes that harbor genes that regulate BMD. Specifically, we evaluated 24 wk old C57BL/6J-Chr #A/J/NaJ CSS ( n = 7 to 18) in which each chromosome in the host C57BL/6J strain is replaced by a corresponding chromosome from the donor A/J strain (19 autosomes, X, Y). We determined several A/J chromosomes contribute to body weight (BW), percent body fat (BF), whole body areal BMD (aBMD), and serum insulin-like growth factor (IGF)-I in both a positive and negative manner when compared with C57BL/6J. Specifically, C57BL/6J-Chr 5A/J/NaJ (B.A-5) (males) and B.A-13 (females) contributed to increased BW, whereas B.A-3, 4, 8, 9, 12, and 18 (males) and B.A-3, 4, and 11 (females) contributed to reduced BW. B.A-5 (males) and B.A-13 (females) contributed to increased BF, whereas B.A-12 (males) and B.A-3, 4, 10, and 11 (females) contributed to reduced BF. B.A-14 (females) contributed to increased aBMD and B.A-1, 2, 6, 9, 10, and 18 (males) and B.A-8, 9, and 10 (females) contributed to reduced aBMD. To determine if similar chromosomes regulate aBMD and IGF-I, we determined serum concentrations of IGF-I. B.A-14 and Y (males) and B.A-6 (females) contributed to increased IGF-I and male B.A-3 and female B.A-8 contributed to reduced IGF-I. Overall, we identified several sex-dependent and -independent chromosomes that regulate aBMD and IGF-I in adult mice.

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Bone Mineral Density in Elite DanceSport Athletes

Medical Problems of Performing Artists ◽

10.21091/mppa.2016.1005 ◽

2016 ◽

Vol 31 (1) ◽

pp. 25-28 ◽

Cited By ~ 3

Author(s):

Helena Kruusamäe ◽

Katre Maasalu ◽

Jaak Jurimäe

Keyword(s):

Bone Mineral Density ◽

Femoral Neck ◽

Body Fat ◽

Bone Mineral ◽

Weight Bearing ◽

Whole Body ◽

Percent Body Fat ◽

Mineral Density ◽

Same Gender ◽

Body Bone

This study compared bone mineral density (BMD) variables of female and male elite dancesport athletes with untrained control subjects of the same gender. Sixty-six elite dancesport athletes (M 33, F 33) and 64 untrained controls (M 34, F 31) participated in this study. Elite dancesport athletes were dancing couples competing at the international level. Whole-body bone mineral content and whole-body, forearm, lumbar-spine, and femoral-neck BMD, as well as whole-body fat mass and fat free mass, were measured by dual-energy X-ray absorptiometry. There were no differences (p>0.05) in height and body mass between dancers and controls of the same gender, but percent body fat was lower (p<0.05) in dancers of both genders than in untrained controls. Elite dancesport athletes had significantly higher femoral-neck BMD, and male dancers also higher whole-body BMD values when compared with controls of the same gender. All other measured bone mineral values did not differ between the groups of the same gender. In addition, training experience was positively correlated with whole-body BMD (r=0.27; p<0.05) in dancesport athletes. Based on this study, it can be concluded that elite dancesport athletes have higher BMD values at the weight-bearing site (femoral-neck BMD), while other measured areas and whole-body bone mineral values do not differ from the corresponding values of healthy sedentary controls of the same gender. According to our results, low BMD is not an issue for elite female dancesport athletes, despite their lower percent body fat values.

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Subchondral tibial bone mineral density predicts future joint space narrowing at the medial femoro-tibial compartment in patients with knee osteoarthritis

Bone ◽

10.1016/s8756-3282(03)00059-0 ◽

2003 ◽

Vol 32 (5) ◽

pp. 541-545 ◽

Cited By ~ 54

Author(s):

O Bruyere ◽

C Dardenne ◽

E Lejeune ◽

B Zegels ◽

A Pahaut ◽

...

Keyword(s):

Bone Mineral Density ◽

Knee Osteoarthritis ◽

Bone Mineral ◽

Joint Space Narrowing ◽

Joint Space ◽

Mineral Density ◽

Tibial Bone

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Weight bearing aerobic exercises versus whole body vibration on bone mineral density post thyroidectomy

10.14198/jhse.2021.16.proc2.25 ◽

2021 ◽

Author(s):

Shaimaa Mohamed Elsayeh ◽

Noran Ahmed Elbehery ◽

Zeinab A. Ali

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Weight Bearing ◽

Whole Body Vibration ◽

Whole Body ◽

Mineral Density ◽

Body Vibration

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Correlation Between Weight Bearing Asymmetry and Bone Mineral Density in Patients With Bilateral Knee Osteoarthritis

10.21203/rs.3.rs-141477/v1 ◽

2021 ◽

Author(s):

Kohei Nishizawa ◽

Kengo Harato ◽

Yutaro Morishige ◽

Shu Kobayashi ◽

Yasuo Niki ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Clinical Data ◽

Weight Bearing ◽

Mineral Density ◽

Femorotibial Angle ◽

Knee Oa ◽

Bilateral Knee ◽

Gait Parameters ◽

The Relationship

Abstract Background: Although unloading of the joint is related to reduction of the local bone mineral density (BMD), little attention had been paid to the relationship between loading asymmetry and side-to-side difference of BMD in patients with bilateral knee osteoarthritis (OA). The aim of the present study was to evaluate and clarify the relationship between gait parameters and bone mineral density in those patients.Methods: A total of 36 knees in eighteen patients (mean age = 73.7 ± 6.3 years, mean body mass index = 26.7 ± 3.8 kg/m2) with bilateral medial knee OA were enrolled in the present study. All subjects performed relaxed standing and level walking at our gait laboratory after informed consent was obtained. First, ground reaction force was calculated on bilateral knees during standing. The knees in each patient were divided into Higher and Lower force side for the definition of dominant side limb. Second, gait parameters in each subject were obtained. To analyze the factors that affect the weight bearing distribution in both limbs, clinical data and biomechanical parameters were compared between knees. Clinical data included radiographic OA grade, femorotibial angle and BMD at the bilateral femoral neck.Results: Knees on Higher force side were significantly more extended than on Lower force side in standing (P=0.012) and knee excursion during weight acceptance phase in gait was significantly larger in Higher side than in Lower side (P=0.006), while the other parameters were not significantly different. As to the clinical data, Higher force side had greater BMD, compared to Lower force side. In terms of Kellgren-Lawrence scale and femorotibial angle on plain radiographs, there were no significant differences between Higher and Lower force side.Conclusions: Based on loading asymmetry in the present study, lower BMD was observed on Lower force side in patients with knee OA. Therefore, it is helpful for orthopedic surgeons to examine side-to-side differences of bone mineral density or extension limitation during standing for evaluation of the loading condition in patients with bilateral knee OA.

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Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men

AIDS Research and Treatment ◽

10.1155/2012/103072 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5

Author(s):

Madhu N. Rao ◽

Morris Schambelan ◽

Viva W. Tai ◽

Donald I. Abrams ◽

Hootan Khatami ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Density ◽

Bone Mineral ◽

Fat Distribution ◽

Whole Body ◽

Inverse Association ◽

Mineral Density ◽

Cross Sectional ◽

Increased Risk ◽

The Relationship

HIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. Furthermore, HIV infected individuals on antiretroviral therapy are at increased risk for altered fat distribution, which may impact the relationship between leptin and BMD. In a cross-sectional analysis of data in 107 HIV-infected men, we determined whether serum leptin levels were associated with whole-body BMD and bone mineral content measured by dual-energy X-ray absorptiometry (DEXA), after adjusting for confounders including body fat distribution. We found an inverse association between leptin and bone density in those with peripheral lipoatrophy, defined objectively as <3 kg appendicular fat by DEXA, but no such relationship was seen in those with >3 kg appendicular fat. This result suggests that fat distribution may modify the relationship between leptin and bone density.

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Correlation between weight-bearing asymmetry and bone mineral density in patients with bilateral knee osteoarthritis

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02252-5 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Kohei Nishizawa ◽

Kengo Harato ◽

Yutaro Morishige ◽

Shu Kobayashi ◽

Yasuo Niki ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Clinical Data ◽

Weight Bearing ◽

Mineral Density ◽

Femorotibial Angle ◽

Knee Oa ◽

Bilateral Knee ◽

Gait Parameters ◽

The Relationship

Abstract Background Although unloading of the joint is related to reduction of the local bone mineral density (BMD), little attention had been paid to the relationship between loading asymmetry and side-to-side difference of BMD in patients with bilateral knee osteoarthritis (OA). The aim of the present study was to evaluate and clarify the relationship between gait parameters and bone mineral density in those patients. Methods A total of 36 knees in eighteen patients (mean age = 73.7 ± 6.3 years, mean body mass index = 26.7 ± 3.8 kg/m2) with bilateral medial knee OA were enrolled in the present study. All subjects performed relaxed standing and level walking at our gait laboratory after informed consent was obtained. First, ground reaction force was calculated on bilateral knees during standing. The knees in each patient were divided into higher and lower force side for the definition of dominant side limb. Second, gait parameters in each subject were obtained. To analyze the factors that affect the weight-bearing distribution in both limbs, clinical data and biomechanical parameters were compared between knees. Clinical data included radiographic OA grade, femorotibial angle, and BMD at the bilateral femoral neck. Results Knees on higher force side were significantly more extended than on lower force side in standing (P = 0.012) and knee excursion during weight acceptance phase in gait was significantly larger in higher side than in lower side (P = 0.006), while the other parameters were not significantly different. As to the clinical data, higher force side had greater BMD, compared to lower force side. In terms of Kellgren–Lawrence scale and femorotibial angle on plain radiographs, there were no significant differences between higher and lower force side. Conclusions Based on loading asymmetry in the present study, lower BMD was observed on Lower force side in patients with knee OA. Therefore, it is helpful for orthopedic surgeons to examine side-to-side differences of bone mineral density or extension limitation during standing for evaluation of the loading condition in patients with bilateral knee OA.

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