scholarly journals Acute necrotising encephalopathy in a child with H1N1 influenza infection: a clinicoradiological diagnosis and follow-up

2016 ◽  
pp. bcr2015213429 ◽  
Author(s):  
Sangeetha Yoganathan ◽  
Sniya Valsa Sudhakar ◽  
Ebor Jacob James ◽  
Maya Mary Thomas
Keyword(s):  
Influenza Infection ◽  
H1n1 Influenza ◽  
Acute Necrotising Encephalopathy ◽  
Acute Necrotising

scholarly journals Computed tomography findings in patients with H1N1 influenza A infection

2013 ◽  
Vol 46 (5) ◽  
pp. 299-306 ◽  
Author(s):  
Viviane Brandão Amorim ◽  
Rosana Souza Rodrigues ◽  
Miriam Menna Barreto ◽  
Gláucia Zanetti ◽  
Edson Marchiori
Keyword(s):  
Computed Tomography ◽  
Influenza A ◽  
H1n1 Virus ◽  
Severe Disease ◽  
H1n1 Influenza ◽  
Wall Thickening ◽  
High Resolution Computed Tomography ◽  
Air Trapping ◽  
Bronchial Wall

The present study aimed to review high resolution computed tomography findings in patients with H1N1 influenza A infection. The most common tomographic findings include ground-glass opacities, areas of consolidation or a combination of both patterns. Some patients may also present bronchial wall thickening, airspace nodules, crazy-paving pattern, perilobular opacity, air trapping and findings related to organizing pneumonia. These abnormalities are frequently bilateral, with subpleural distribution. Despite their nonspecificity, it is important to recognize the main tomographic findings in patients affected by H1N1 virus in order to include this possibility in the differential diagnosis, characterize complications and contribute in the follow-up, particularly in cases of severe disease.

scholarly journals Study of Neuraminidase-Inhibiting Antibodies in Clinical Trials of Live Influenza Vaccines

Antibodies ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 20
Author(s):  
Yulia Desheva ◽  
Tatiana Smolonogina ◽  
Svetlana Donina ◽  
Larisa Rudenko
Keyword(s):  
Immune Response ◽  
Clinical Trials ◽  
Immune Responses ◽  
Influenza Infection ◽  
H1n1 Influenza ◽  
Antibody Responses ◽  
Influenza Vaccines ◽  
Statistical Relationship ◽  
Serum Samples ◽  
H5n1 Influenza

Background: Currently, the immunogenicity of influenza vaccines is assessed by detecting an increase of hemagglutination inhibition (HI) antibodies. As neuraminidase (NA)-based immunity may be significant in protecting against influenza infection, detection of neuraminidase inhibiting (NI) antibodies may improve the assessment of the immunogenicity of influenza vaccines. Methods: We investigated the immune response to NA in people after immunization with live influenza vaccines (LAIVs). A number of A/H7NX or A/H6NX viruses were used to detect NI antibodies, using an enzyme-linked lectin assay (ELLA). Results: Seasonal LAIV immunization stimulated an increase in NI antibodies not only to homologous A/H1N1 influenza, but also to A/H1N1pdm09 and A/H5N1 influenza. After A/17/California/09/38 (H1N1) pdm09 LAIV vaccination, there was no statistical relationship between post-vaccinated antibody seroconversion and two surface glycoproteins in serum samples obtained from the same individuals (p = 0.24). Vaccination with LAIV of H5N2, H2N2, H7N3, and H7N9 subtypes led to 7%–29.6% NI antibody seroconversions in the absence of HI antibody conversions. There was relatively low coordination of hemagglutinin (HA) and NA antibody responses (r = 0.24–0.59). Conclusions: The previously noted autonomy for HI and NI immune responses was confirmed when assessing the immunogenicity of LAIVs. Combining the traditional HI test with the detection of NI antibodies can provide a more complete assessment of LAIV immunogenicity.

scholarly journals Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 197 ◽  
Author(s):  
Anna Kirsteina ◽  
Inara Akopjana ◽  
Janis Bogans ◽  
Ilva Lieknina ◽  
Juris Jansons ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Matrix Protein ◽  
Influenza Infection ◽  
Alpha Helix ◽  
H1n1 Influenza ◽  
Dimensional Structure ◽  
Effective Vaccine ◽  
High Dose ◽  
Virus Challenge ◽  
Practical Applications

Influenza, an acute, highly contagious respiratory disease, remains a significant threat to public health. More effective vaccination strategies aimed at inducing broad cross-protection not only against seasonal influenza variants, but also zoonotic and emerging pandemic influenza strains are urgently needed. A number of conserved protein targets to elicit such cross-protective immunity have been under investigation, with long alpha-helix (LAH) from hemagglutinin stalk and ectodomain of matrix protein 2 ion channel (M2e) being the most studied ones. Recently, we have reported the three-dimensional structure and some practical applications of LAH expressed in Escherichia coli system (referred to as tri-stalk protein). In the present study, we investigated the immunogenicity and efficacy of a panel of broadly protective influenza vaccine prototypes based on both influenza tri-stalk and triple M2e (3M2e) antigens integrated into phage AP205 virus-like particles (VLPs). While VLPs containing the 3M2e alone induced protection against standard homologous and heterologous virus challenge in mice, only the combination of both conserved influenza antigens into a single VLP fully protected mice from a high-dose homologous H1N1 influenza infection. We propose that a combination of genetic fusion and chemical coupling techniques to expose two different foreign influenza antigens on a single particle is a perspective approach for generation of a broadly-effective vaccine candidate that could protect against the constantly emerging influenza virus strains.

scholarly journals 2009 H1N1 influenza infection in Korean healthcare personnel

2011 ◽  
Vol 30 (10) ◽  
pp. 1201-1206 ◽  
Author(s):  
J. S. Yeom ◽  
J.-H. Lee ◽  
I.-G. Bae ◽  
W.-S. Oh ◽  
C.-S. Moon ◽  
...  
Keyword(s):  
Influenza Infection ◽  
H1n1 Influenza ◽  
Healthcare Personnel ◽  
2009 H1n1
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