Macular hole closure following spontaneous release of vitreomacular traction

AbstractThe primary objective was to create and establish a new formula that predicts the individual probability of macular hole closure for eyes with full thickness macular holes (FTMH) accompanied by vitreomacular traction (VMT) which received enzymatic vitreolysis using intravitreally administered ocriplasmin. The secondary objective was to evaluate the forecast reliability of a previously published formula for VMT resolution in VMT-only eyes (OddsIVO-Success = eIntercept × ORyears × ORln(µm); ProbabilityIVO-Success = OddsIVO-Success/(OddsIVO-Success + 1)) on VMT resolution using the current dataset of eyes with FTMH accompanied by VMT. Retrospective analysis of the OASIS, ORBIT, and INJECT-studies. Patients with FTMH and VMT with complete information (n = 213) were included. The effect of gender, age, FTMH diameter, lens status and the presence of epiretinal membranes (ERM) on FTMH closure was assessed using separate univariate logistic regression analyses. With regard to VMT release separate univariate regression analyses were carried out and results were compared with formerly published data of VMT resolution in eyes with VMT only. Overall, 126 eyes (63%) experienced VMT resolution within 28 days. Younger age (p < 0.0001) and VMT diameter (p = 0.041) had a significant impact on VMT release. Overall, 81 eyes (38%) treated with ocriplasmin showed FTMH closure within 28 days. Univariate analysis of the different predictors analyzed revealed that FTMH diameter < 250 µm had a significant impact on treatment success (p = 0.0495). It was not possible to calculate and establish a new multivariate formula that can predict the individual FTMH closure probability for eyes with FTMHs and VMT. However, the results of VMT release prediction in eyes with FTMHs accompanied by VMT matched the prediction of VMT release in eyes with VMT only when using the previously published formula. All in all, predictors for calculating the individual probability of VMT resolution on the one hand and FTMH closure on the other hand are different suggesting diverse pathophysiological mechanisms.

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Delayed full-thickness macular hole closure without vitreomacular traction release following ocriplasmin injection

BMJ Case Reports ◽

10.1136/bcr-2015-212181 ◽

2015 ◽

pp. bcr2015212181

Author(s):

Sleiman Abou ltaif ◽

Luke Herbert

Keyword(s):

Macular Hole ◽

Vitreomacular Traction ◽

Full Thickness ◽

Full Thickness Macular Hole ◽

Hole Closure

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Scanning Laser Ophthalmoscope Correlations With Biomicroscopic Findings and Foveal Function After Macular Hole Closure

Archives of Ophthalmology ◽

10.1001/archopht.118.2.193 ◽

2000 ◽

Vol 118 (2) ◽

pp. 193 ◽

Cited By ~ 21

Author(s):

Taiichi Hikichi

Keyword(s):

Macular Hole ◽

Scanning Laser Ophthalmoscope ◽

Scanning Laser ◽

Hole Closure

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Refractory Myopic Retinal Detachment and Macular Hole Closure with Autologous Neurosensory Retinal Free Flap

Case Reports in Ophthalmology ◽

10.1159/000500275 ◽

2019 ◽

Vol 10 (2) ◽

pp. 160-164 ◽

Cited By ~ 1

Author(s):

Filipe Sousa Neves ◽

Joana Braga ◽

Paula Sepúlveda ◽

Miguel Bilhoto

Keyword(s):

Retinal Detachment ◽

Macular Hole ◽

Free Flap ◽

Vision Loss ◽

Silicone Oil ◽

Modified Technique ◽

Alternative Approach ◽

Retinal Atrophy ◽

One Year ◽

Hole Closure

The purpose of this case report is to describe a modified technique involving the use of an autologous neurosensory retinal free flap for closure of a macular hole (MH) during retinal detachment (RD) surgery. A 50-year-old female presented with sudden vision loss (light perception only) and a recurrent myopic RD associated with an MH. An autologous neurosensory retinal free flap was obtained and moved toward the MH. Silicone oil was used as an endotamponade and removed after 6 months. Two months after oil removal visual acuity improved to 20/400 and remained stable thereafter; however, the patient developed central retinal atrophy. One year after surgery the MH was closed and the retina attached. This modified technique with the use of an autologous neurosensory retinal flap provides an alternative approach for recurrent MH in RD procedures.

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Development of Stage 4 Macular Hole after Spontaneous Closure in a Patient with Stage 2 Macular Hole and a Lamellar Macular Hole-Associated Epiretinal Proliferation

Case Reports in Ophthalmology ◽

10.1159/000513132 ◽

2021 ◽

pp. 481-484

Author(s):

Masahisa Watanabe ◽

Harumasa Yokota ◽

Hiroshi Aso ◽

Hirotsugu Hanazaki ◽

Junya Hanaguri ◽

...

Keyword(s):

Visual Acuity ◽

Macular Hole ◽

Spontaneous Closure ◽

Surgical Removal ◽

Lamellar Macular Hole ◽

Full Thickness ◽

Stage 4 ◽

Full Thickness Macular Hole ◽

The Right ◽

Hole Closure

Herein, we report the longitudinal observation of a case with reopening of the macular hole associated with a lamellar macular hole-associated epiretinal proliferation (LHEP) followed by spontaneous closure in patients with stage 2 idiopathic macular hole. A 64-year-old woman was referred for the decreased visual acuity (VA) and acute anorthopia in the right eye. Funduscopy and optical coherence tomography (OCT) showed stage 2 full-thickness macular hole without posterior vitreous detachment (PVD) and operculum formation. Her best-corrected visual acuity (BCVA) was 20/32. One month later, the diameter of the macular hole was getting small and VA improved. Six months later, the macular hole was treated spontaneously with the attached hyaloid membrane to the macula by OCT and the BCVA improved to 20/20. Fourteen months after the first visit, the BCVA decreased to 20/50 and the patient was diagnosed with stage 4 macular hole with complete PVD. OCT showed full-thickness macular hole with a LHEP in the right eye. After 25G-gauge vitrectomy with the peeling of internal limiting membrane (ILM) and LHEP, the macular hole was closed and BCVA finally improved to 20/25. Spontaneous macular hole closure without PVD may rarely occur in patients with LHEP. The surgical removal of ILM and LHEP may contribute to the successful macular hole closure after vitrectomy.

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Baseline Characteristics and Vitreoretinal Interface Features in Patients with Vitreomacular Traction and Macular Hole from the MIVI-TRUST Clinical Program

Value in Health ◽

10.1016/j.jval.2013.08.1143 ◽

2013 ◽

Vol 16 (7) ◽

pp. A502

Author(s):

B. Lescrauwaet ◽

Z. Koshy ◽

A. Labourette ◽

L. Duchateau

Keyword(s):

Macular Hole ◽

Vitreomacular Traction ◽

Vitreoretinal Interface ◽

Clinical Program ◽

Baseline Characteristics

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Autologous Lens Capsule Flap Transplantation for Persistent Macular Holes

Journal of Ophthalmology ◽

10.1155/2021/8148792 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Sławomir Cisiecki ◽

Karolina Bonińska ◽

Maciej Bednarski

Keyword(s):

Macular Hole ◽

Functional Outcomes ◽

Lens Capsule ◽

Operative Techniques ◽

Basal Diameter ◽

Macular Holes ◽

Capsular Flap ◽

Potential Alternative ◽

The Mean ◽

Hole Closure

Purpose. To analyze the anatomical and functional outcomes after autologous lens capsule transplantation in patients with persistent macular hole. Methods. This is a retrospective observational study of five eyes of five patients treated with vitrectomy and autologous lens capsular flap transplantation. Complete ophthalmic examination was performed preoperatively and seven days and 1, 3, 6, 12, and 18 months after surgery. Results. Successful macular hole closure was achieved in all patients. The mean minimum macular hole diameter before the surgery was 666.8 µm, and the mean basal diameter was 1086.4 µm. The mean visual acuity before lens capsular flap transplantation was 20/200, while after surgery, it was 20/125. Conclusions. Autologous lens capsular flap transplantation is a potential alternative treatment for patients with large persistent macular holes after other operative techniques have failed.

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