scholarly journals Severe tardive dyskinesia induced by domperidone in presenile and non-dementia type 2 diabetes man with alcohol misuse showing albuminocytological dissociation and white matter hyperintensity

2019 ◽  
Vol 12 (5) ◽  
pp. e228789 ◽  
Author(s):  
Akinori Kanzaki ◽  
Hidetoshi Tada ◽  
Akihito Otsuka ◽  
Tadashi Nakamura

Domperidone has difficulty passing the blood–brain barrier, thus rarely causes tardive dyskinesia. Furthermore, its symptoms in adults are generally mild. Although both alcohol and diabetes are thought to increase the risk of development of tardive dyskinesia, their impact remains controversial, especially diabetes, and factors related to worsened tardive dyskinesia have not been clearly elucidated. A 59-year-old man with type 2 diabetes and history of alcohol misuse, who had been chronically prescribed domperidone at 15 mg/day, showed severe tardive dyskinesia, which was remitted within several days by stopping the drug. In our case, albuminocytological dissociation and white matter hyperintensity on MRI were confirmed, which were thought to be related to blood–brain barrier dysfunction. This present findings indicate that alcohol misuse and type 2 diabetes, as well as albuminocytological dissociation and white matter hyperintensity may result in severe tardive dyskinesia, even in individuals receiving domperidone.

2020 ◽  
Author(s):  
Craig Ferris ◽  
Ju Qiao ◽  
Christopher M Lawson ◽  
Kilian FG Rentrup ◽  
Praveen Kulkarni

Abstract Background This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood brain barrier in a rat model of type 2 diabetes with the presumption that small vessel disease is a contributing factor to neuropathology in diabetes. Methods The BBZDR/Wor rat, a model of type 2 diabetes, and age-matched controls were studied for changes in blood brain barrier permeability. QUTE-CE, a quantitative vascular biomarker, generated angiographic images with over 500,000 voxels that were registered to a 3D MRI rat brain atlas providing site-specific information on blood-brain barrier permeability in 173 different brain areas. Results In this model of diabetes, without the support of insulin treatment, there was global capillary pathology with over 84% of the brain showing a significant increase in blood brain barrier permeability over wild-type controls. Areas of the cerebellum and midbrain dopaminergic system were not significantly affected.Conclusion Small vessel disease as assessed by permeability in the blood brain barrier in type 2 diabetes is pervasive and includes much of the brain. The increase in blood-brain barrier permeability is a likely contributing factor to diabetic encephalopathy and dementia.


2018 ◽  
Vol 56 (4) ◽  
pp. 2314-2327 ◽  
Author(s):  
Zhanyang Yu ◽  
Li Lin ◽  
Yinghua Jiang ◽  
Ian Chin ◽  
Xiaojie Wang ◽  
...  

2016 ◽  
Vol 78 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Dae Young YOO ◽  
Hee Sun YIM ◽  
Hyo Young JUNG ◽  
Sung Min NAM ◽  
Jong Whi KIM ◽  
...  

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ju Qiao ◽  
Christopher M. Lawson ◽  
Kilian F. G. Rentrup ◽  
Praveen Kulkarni ◽  
Craig F. Ferris

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Yonatan Serlin ◽  
Jaime Levy ◽  
Hadar Shalev

Vascular pathology is recognized as a principle insult in type 2 diabetes mellitus (T2DM). Co-morbidities such as structural brain abnormalities, cognitive, learning and memory deficits are also prevailing in T2DM patients. We previously suggested that microvascular pathologies involving blood-brain barrier (BBB) breakdown results in leakage of serum-derived components into the brain parenchyma, leading to neuronal dysfunction manifested as psychiatric illnesses. The current postulate focuses on the molecular mechanisms controlling BBB permeability in T2DM, as key contributors to the pathogenesis of mental disorders in patients. Revealing the mechanisms underlying BBB dysfunction and inflammatory response in T2DM and their role in metabolic disturbances, abnormal neurovascular coupling and neuronal plasticity, would contribute to the understanding of the mechanisms underlying psychopathologies in diabetic patients. Establishing this link would offer new targets for future therapeutic interventions.


2018 ◽  
Vol 13 (2) ◽  
pp. 389-395 ◽  
Author(s):  
C. Eleana Zhang ◽  
Sau May Wong ◽  
Renske Uiterwijk ◽  
Walter H. Backes ◽  
Jacobus F. A. Jansen ◽  
...  

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