Reappraisal of haemorrhagic suprasellar pilocytic astrocytoma during adulthood

Pilocytic astrocytomas comprise the most common central nervous system tumour during childhood and have an excellent response to surgical treatment in this population. The tumour incidence decreases with age, whereas more aggressive behaviour tends to increase. Haemorrhage as a presenting feature of pilocytic astrocytomas is a rare phenomenon, especially in the adult population. We present a case of a 55-year-old patient with progressive headaches and dizziness. MRI confirmed a sellar and predominantly retrochiasmal suprasellar lesion with heterogeneous signal, enhancement and blood products. Management via transsphenoidal approach was performed, and histopathology revealed the unexpected diagnosis of haemorrhagic pilocytic astrocytoma. Haemorrhagic pilocytic astrocytoma is an infrequent entity in the adult population and it is essential to recognise the peculiarities regarding diagnostic evaluation and management, which differ from the paediatric population. During adulthood, this tumour carries an overall unfavourable prognosis, with higher rates of progression and recurrence.

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Clinicoepidemiological pattern of paediatric central nervous system tumour: A single institutional experience in North East India

Pediatric Hematology Oncology Journal ◽

10.1016/j.phoj.2021.04.021 ◽

2020 ◽

Vol 5 (4) ◽

pp. S8-S9

Author(s):

Munlima Hazarika ◽

Sreya Mallik ◽

Bhargab Jyoti. Saikia ◽

Partha Sarathi. Roy ◽

Satya Sadhan. Sarangi ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

North East India ◽

North East ◽

Central Nervous System Tumour ◽

Institutional Experience

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Embryology of Spinal Dysraphism and its Relationship to Surgical Treatment

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2020.75 ◽

2020 ◽

Vol 47 (6) ◽

pp. 736-746

Author(s):

Matthew E. Eagles ◽

Nalin Gupta

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Surgical Treatment ◽

Gestational Age ◽

Congenital Malformations ◽

Spinal Dysraphism ◽

Embryological Development ◽

Correct Treatment ◽

Pathological Correlation ◽

The Central Nervous System

ABSTRACT:Spinal dysraphism is an umbrella term that encompasses a number of congenital malformations that affect the central nervous system. The etiology of these conditions can be traced back to a specific defect in embryological development, with the more disabling malformations occurring at an earlier gestational age. A thorough understanding of the relevant neuroembryology is imperative for clinicians to select the correct treatment and prevent complications associated with spinal dysraphism. This paper will review the neuroembryology associated with the various forms of spinal dysraphism and provide a clinical-pathological correlation for these congenital malformations.

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55 Malignant primary brain and other central nervous system tumours diagnosed in the Canadian population from 2009 to 2013

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2018.306 ◽

2018 ◽

Vol 45 (S3) ◽

pp. S16-S17

Author(s):

EV Walker ◽

F Davis ◽

Keyword(s):

United States ◽

Central Nervous System ◽

Nervous System ◽

Brain Tumour ◽

Age Distribution ◽

Paediatric Population ◽

The United States ◽

Incidence Rates ◽

Canadian Population ◽

Cns Tumours

The Canadian Brain Tumour Registry (CBTR) project was established in 2016 with the aim of enhancing infrastructure for surveillance and clinical research to improve health outcomes for brain tumour patients in Canada. We present a national surveillance report on malignant primary brain and central nervous system (CNS) tumours diagnosed in the Canadian population from 2009-2013. Patients were identified through the Canadian Cancer Registry (CCR); an administrative dataset that includes cancer incidence data from all provinces/territories in Canada. Cancer diagnoses are coded using the ICD-O3 system. Tumour types were classified by site and histology using The Central Brain Tumour Registry of the United States definitions. Incidence rates (IR) and 95% confidence intervals (CI) were calculated per 100,000 person-years and standardized to the 2011 census population age-distribution. Overall, 12,115 malignant brain and CNS tumours were diagnosed in the Canadian population from 2009-2013 (IR:8.43;95%CI:8.28,8.58). Of these, 6,845 were diagnosed in males (IR:9.72;95%CI:9.49,9.95) and 5,270 in females (IR:7.20;95%CI:7.00,7.39). The most common histology overall was glioblastoma (IR:4.06;95%CI:3.95,4.16). Among those aged 0-19 years, 1,130 malignant brain and CNS tumours were diagnosed from 2009-2013 (IR:3.36;95%CI:3.16,3.56). Of these, 625 were diagnosed in males (IR:3.32;95%CI:3.34,3.92) and 505 in females (IR:3.08;95%CI:2.81,3.36). The most common histology among the paediatric population was pilocytic astrocytoma (IR:0.73;95%CI:0.64,0.83). The presentation will include: IRs for other histologies, the geographic distribution of cases and a comparison between Canada and the United States.

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Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20170001 ◽

2017 ◽

Vol 75 (2) ◽

pp. 92-95 ◽

Cited By ~ 3

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Joseph Bruno Bidin Brooks ◽

Sidney Gomes ◽

Marcus Vinicius Magno Goncalves ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Disease Onset ◽

Clinical Findings ◽

Neurological Dysfunction ◽

Superficial Siderosis ◽

Blood Products ◽

The Central Nervous System ◽

Magnetic Resonance Imaging Mri ◽

Intermittent Bleeding

ABSTRACT Superficial siderosis (SS) of the central nervous system (CNS) is a rare and possibly underdiagnosed disorder resulting from chronic or intermittent bleeding into the subarachnoid space, leading to deposition of blood products in the subpial layers of the meninges. Magnetic resonance imaging (MRI) shows a characteristic curvilinear pattern of hypointensity on its blood-sensitive sequences. Methods Series of cases collected from Brazilian centers. Results We studied 13 cases of patients presenting with progressive histories of neurological dysfunction caused by SS-CNS. The most frequent clinical findings in these patients were progressive gait ataxia, hearing loss, hyperreflexia and cognitive dysfunction. The diagnoses of SS-CNS were made seven months to 30 years after the disease onset. Conclusion SS-CNS is a rare disease that may remain undiagnosed for long periods. Awareness of this condition is essential for the clinician.

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