Anti-glomerular basement membrane disease and IgA nephropathy in a patient with previous renal cell carcinoma

A 66-year-old Asian woman presented with severe kidney injury, microscopic haematuria and subnephrotic range proteinuria with elevated serum anti-glomerular basement membrane (anti-GBM) titre. She had a history of renal cell carcinoma. Renal biopsy revealed dual pathology with immunofluorescence showing 3+ linear glomerular IgG staining and 3+ IgA mesangial staining. Cellular crescents were present on light microscopy and electron microscopy revealed increased mesangial matrix. She was treated with plasma exchange and immunosuppression and remained in stage 4 chronic kidney disease. This case describes the coexistence of anti-GBM disease and IgA nephropathy, a phenomenon not well described in the literature. The report also explores the association of malignancy and glomerulonephritis as well as the role of genetics and the utility of human leukocyte antigen (HLA) typing in risk stratification.

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219: Impact of Increased Erythropoietin Receptor Expression and Elevated Serum Erythropoietin Levels on Clinicopathological Features and Prognosis in Renal Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)30484-1 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 73-73

Author(s):

Keiichi Ito ◽

Tomohiko Asano ◽

Takaka Asano ◽

Akinori Sato ◽

Akio Horiguchi ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Elevated Serum ◽

Clinicopathological Features ◽

Erythropoietin Receptor ◽

Receptor Expression ◽

Serum Erythropoietin

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Long-term treatment with human leukocyte interferon (IFN) and melatonin (MLT) in metastatic renal cell carcinoma

Cytokine ◽

10.1016/1043-4666(94)90094-9 ◽

1994 ◽

Vol 6 (5) ◽

pp. 541

Author(s):

B. Neri ◽

G. Cini ◽

MT. Gemelli ◽

MC. Paoletti ◽

G. Grechi

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Human Leukocyte ◽

Term Treatment ◽

Long Term Treatment ◽

Human Leukocyte Interferon

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The relationship between human leukocyte antigens (HLA) and renal cell carcinoma

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2010.2661 ◽

2010 ◽

Vol 10 (4) ◽

pp. 282-286 ◽

Cited By ~ 1

Author(s):

Erkan Yılmaz ◽

Arman Çekmen ◽

Emre Akkuş ◽

Bülent Önal ◽

Ali Uğur Özalp ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Patient Group ◽

Renal Cell ◽

Human Leukocyte ◽

Control Group ◽

Human Leukocyte Antigens ◽

Leukocyte Antigens ◽

The People ◽

The Relationship

Etiologies of Renal Cell Carcinoma (RCC) are not clear despite of the fact that many risk factors have been suggested. Especially in high stages RCC can affect the immune system in various ways. Human Leukocyte Antigens (HLA) may play a complementary role in the activation between the tumor and immunity. Our aim was to determine the existence of the relationship between HLA system and RCC. By using the standard microlymphocytotoxic method of Terasaki in our study, the HLA A, B, DR and DQ antigen types of 20 patients with RCC Stage Ti and T2 were compared with the control group consisting of healthy 30 people. In our RCC patient group, HLA-A23(9) and DQ7(3) antigens were significantly higher than the control group statistically (p=0.005, p=0.0028; respectively). HLA-A10, DQi, DR10 and B44 antigens were significantly higher in the control group than the patient group (p=0.011; for all). The findings made us suggest that the people, carrying the antigens which were detected in the patient group, were at high risk for RCC and the people, carrying the protective antigens that were detected in the control group were at less risk for RCC. There may be a dramatic regression for the patients who underwent immunotherapy and HLA expression, which is known to play role in tumor biology, may direct the effects of immunotherapeutic agents. Immunologic description and destruction is avoided in case of change or disappearance of HLA expression by cancer cells. Further investigations which will be performed in our population in the future will be more illuminating to confirm those results. We have concluded that, HLA profiles may be evaluated for detection the people at risk of RCC, the prognosis of the patients and their treatments.

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